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Cytologic features of 22 radial scar/complex sclerosing lesions of the breast, three of which associated with carcinoma: clinical, mammographic, and histologic correlation.
Diagn Cytopathol. 1997 Nov; 17(5):353-62.DC

Abstract

Radial scar/complex sclerosing lesion (RS/CSL) of the breast has become more frequently detected with the increasing performance of mammography as a screening test. The clinical, mammographic, and cytologic features of 22 cases of histologically proved breast RS/CSL, 3 of which associated with carcinoma arising at the periphery of the lesion, were reviewed. Clinical examination and mammography did not show specific features in differentiating RS/CSL from carcinoma of the breast. Cytology of RS/CSL without associated malignant changes was dominated by bland epithelial clusters and bipolar naked nuclei. Apocrine cells, papillary clusters, foam cells, and fibrillary elastoid material were also frequently seen. At the cytologic review, only one case of RS with apocrine adenosis, showing atypical cells, was diagnosed as suspicious. Two of the three cases of CSL with associated carcinoma in situ were cytologically characterized by the presence of single atypical cells. In the third case, characterized by a small tubular carcinoma near to CSL, fine-needle aspiration cytology revealed few tubular clusters without myoepithelial cells. Although cytology of RS/CSL without associated carcinoma does not seem characteristic, in most cases a diagnosis of benignancy can be performed correctly. The application of fine-needle aspiration cytology to mammographic lesions with features suggesting RS/CSL may permit a better planning of these lesions.

Authors+Show Affiliations

Department of Pathology, S. Chiara Hospital, Trento, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9360048

Citation

Bonzanini, M, et al. "Cytologic Features of 22 Radial Scar/complex Sclerosing Lesions of the Breast, Three of Which Associated With Carcinoma: Clinical, Mammographic, and Histologic Correlation." Diagnostic Cytopathology, vol. 17, no. 5, 1997, pp. 353-62.
Bonzanini M, Gilioli E, Brancato B, et al. Cytologic features of 22 radial scar/complex sclerosing lesions of the breast, three of which associated with carcinoma: clinical, mammographic, and histologic correlation. Diagn Cytopathol. 1997;17(5):353-62.
Bonzanini, M., Gilioli, E., Brancato, B., Pellegrini, M., Mauri, M. F., & Dalla Palma, P. (1997). Cytologic features of 22 radial scar/complex sclerosing lesions of the breast, three of which associated with carcinoma: clinical, mammographic, and histologic correlation. Diagnostic Cytopathology, 17(5), 353-62.
Bonzanini M, et al. Cytologic Features of 22 Radial Scar/complex Sclerosing Lesions of the Breast, Three of Which Associated With Carcinoma: Clinical, Mammographic, and Histologic Correlation. Diagn Cytopathol. 1997;17(5):353-62. PubMed PMID: 9360048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytologic features of 22 radial scar/complex sclerosing lesions of the breast, three of which associated with carcinoma: clinical, mammographic, and histologic correlation. AU - Bonzanini,M, AU - Gilioli,E, AU - Brancato,B, AU - Pellegrini,M, AU - Mauri,M F, AU - Dalla Palma,P, PY - 1997/11/14/pubmed PY - 2000/6/22/medline PY - 1997/11/14/entrez SP - 353 EP - 62 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 17 IS - 5 N2 - Radial scar/complex sclerosing lesion (RS/CSL) of the breast has become more frequently detected with the increasing performance of mammography as a screening test. The clinical, mammographic, and cytologic features of 22 cases of histologically proved breast RS/CSL, 3 of which associated with carcinoma arising at the periphery of the lesion, were reviewed. Clinical examination and mammography did not show specific features in differentiating RS/CSL from carcinoma of the breast. Cytology of RS/CSL without associated malignant changes was dominated by bland epithelial clusters and bipolar naked nuclei. Apocrine cells, papillary clusters, foam cells, and fibrillary elastoid material were also frequently seen. At the cytologic review, only one case of RS with apocrine adenosis, showing atypical cells, was diagnosed as suspicious. Two of the three cases of CSL with associated carcinoma in situ were cytologically characterized by the presence of single atypical cells. In the third case, characterized by a small tubular carcinoma near to CSL, fine-needle aspiration cytology revealed few tubular clusters without myoepithelial cells. Although cytology of RS/CSL without associated carcinoma does not seem characteristic, in most cases a diagnosis of benignancy can be performed correctly. The application of fine-needle aspiration cytology to mammographic lesions with features suggesting RS/CSL may permit a better planning of these lesions. SN - 8755-1039 UR - https://www.unboundmedicine.com/medline/citation/9360048/Cytologic_features_of_22_radial_scar/complex_sclerosing_lesions_of_the_breast_three_of_which_associated_with_carcinoma:_clinical_mammographic_and_histologic_correlation_ DB - PRIME DP - Unbound Medicine ER -