Tags

Type your tag names separated by a space and hit enter

Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice.
Scand J Gastroenterol. 1997 Oct; 32(10):965-73.SJ

Abstract

BACKGROUND

The efficacy of omeprazole, 20 mg once daily, in the treatment of reflux oesophagitis and the therapeutic advantages over the histamine H2 receptor antagonists are well documented. This study assessed 20 mg omeprazole daily (OM20), 10 mg omeprazole daily (OM10), and 150 mg ranitidine (RAN) twice daily for symptom relief in gastro-oesophageal reflux disease (GORD).

METHODS

Patients (n = 994) presenting with heartburn to their general practitioner underwent endoscopy to exclude peptic ulcer disease and were randomized into a UK, multicentre, parallel-group, double-blind comparison of the three treatments for 4 weeks. Symptoms were assessed at clinic visits after 2 and 4 weeks.

RESULTS

Symptom relief after 4 weeks was achieved by 61% (OM20), 49% (OM10), and 40% (RAN) patients (OM20 versus OM10, P < 0.0167; OM20 versus RAN, P < 0.0001; OM10 versus RAN, P < 0.01). Among the patients (32%) with erosive reflux oesophagitis, symptom relief was achieved in 79% (OM20), 48% (OM10), and 33% (RAN) (OM20 versus OM10, P < 0.0001; OM20 versus RAN, P < 0.0001; OM1O versus RAN, NS).

CONCLUSION

Omeprazole, 20 mg, is the most effective initial therapy for relief of GORD symptoms.

Authors+Show Affiliations

Ashfurlong Health Centre, Coldfield, Birmingham, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

9361167

Citation

Venables, T L., et al. "Omeprazole 10 Milligrams once Daily, Omeprazole 20 Milligrams once Daily, or Ranitidine 150 Milligrams Twice Daily, Evaluated as Initial Therapy for the Relief of Symptoms of Gastro-oesophageal Reflux Disease in General Practice." Scandinavian Journal of Gastroenterology, vol. 32, no. 10, 1997, pp. 965-73.
Venables TL, Newland RD, Patel AC, et al. Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice. Scand J Gastroenterol. 1997;32(10):965-73.
Venables, T. L., Newland, R. D., Patel, A. C., Hole, J., Wilcock, C., & Turbitt, M. L. (1997). Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice. Scandinavian Journal of Gastroenterology, 32(10), 965-73.
Venables TL, et al. Omeprazole 10 Milligrams once Daily, Omeprazole 20 Milligrams once Daily, or Ranitidine 150 Milligrams Twice Daily, Evaluated as Initial Therapy for the Relief of Symptoms of Gastro-oesophageal Reflux Disease in General Practice. Scand J Gastroenterol. 1997;32(10):965-73. PubMed PMID: 9361167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice. AU - Venables,T L, AU - Newland,R D, AU - Patel,A C, AU - Hole,J, AU - Wilcock,C, AU - Turbitt,M L, PY - 1997/11/15/pubmed PY - 1997/11/15/medline PY - 1997/11/15/entrez SP - 965 EP - 73 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 32 IS - 10 N2 - BACKGROUND: The efficacy of omeprazole, 20 mg once daily, in the treatment of reflux oesophagitis and the therapeutic advantages over the histamine H2 receptor antagonists are well documented. This study assessed 20 mg omeprazole daily (OM20), 10 mg omeprazole daily (OM10), and 150 mg ranitidine (RAN) twice daily for symptom relief in gastro-oesophageal reflux disease (GORD). METHODS: Patients (n = 994) presenting with heartburn to their general practitioner underwent endoscopy to exclude peptic ulcer disease and were randomized into a UK, multicentre, parallel-group, double-blind comparison of the three treatments for 4 weeks. Symptoms were assessed at clinic visits after 2 and 4 weeks. RESULTS: Symptom relief after 4 weeks was achieved by 61% (OM20), 49% (OM10), and 40% (RAN) patients (OM20 versus OM10, P < 0.0167; OM20 versus RAN, P < 0.0001; OM10 versus RAN, P < 0.01). Among the patients (32%) with erosive reflux oesophagitis, symptom relief was achieved in 79% (OM20), 48% (OM10), and 33% (RAN) (OM20 versus OM10, P < 0.0001; OM20 versus RAN, P < 0.0001; OM1O versus RAN, NS). CONCLUSION: Omeprazole, 20 mg, is the most effective initial therapy for relief of GORD symptoms. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/9361167/Omeprazole_10_milligrams_once_daily_omeprazole_20_milligrams_once_daily_or_ranitidine_150_milligrams_twice_daily_evaluated_as_initial_therapy_for_the_relief_of_symptoms_of_gastro_oesophageal_reflux_disease_in_general_practice_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365529709011211 DB - PRIME DP - Unbound Medicine ER -