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Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response.
Scand J Gastroenterol. 1997 Oct; 32(10):974-9.SJ

Abstract

BACKGROUND

Data are limited on the value of effective antisecretory therapy in the relief of heartburn in patients without oesophagitis.

METHODS

Patients with heartburn, without endoscopic signs of oesophagitis, were randomized to double-blind treatment with omeprazole, 20 or 10 mg once daily, or placebo, for 4 weeks (n = 509). Pre-treatment oesophageal acid exposure was assessed using 24-h intra-oesophageal pH monitoring. Heartburn was assessed at 2 and 4 weeks.

RESULTS

At 4 weeks the proportion of patients with complete absence of heartburn was 46% (95% confidence interval, 39-53%) with 20 mg omeprazole, 31% (25-38%) with 10 mg omeprazole, and 13% (7-20%) with placebo. Satisfaction with therapy was reported by 66%, 57%, and 31% of the patients, respectively.

CONCLUSION

Omeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis.

Authors+Show Affiliations

Dept. of Surgery, Kärnsjukhuset, Skövde, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

9361168

Citation

Lind, T, et al. "Heartburn Without Oesophagitis: Efficacy of Omeprazole Therapy and Features Determining Therapeutic Response." Scandinavian Journal of Gastroenterology, vol. 32, no. 10, 1997, pp. 974-9.
Lind T, Havelund T, Carlsson R, et al. Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol. 1997;32(10):974-9.
Lind, T., Havelund, T., Carlsson, R., Anker-Hansen, O., Glise, H., Hernqvist, H., Junghard, O., Lauritsen, K., Lundell, L., Pedersen, S. A., & Stubberöd, A. (1997). Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scandinavian Journal of Gastroenterology, 32(10), 974-9.
Lind T, et al. Heartburn Without Oesophagitis: Efficacy of Omeprazole Therapy and Features Determining Therapeutic Response. Scand J Gastroenterol. 1997;32(10):974-9. PubMed PMID: 9361168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. AU - Lind,T, AU - Havelund,T, AU - Carlsson,R, AU - Anker-Hansen,O, AU - Glise,H, AU - Hernqvist,H, AU - Junghard,O, AU - Lauritsen,K, AU - Lundell,L, AU - Pedersen,S A, AU - Stubberöd,A, PY - 1997/11/15/pubmed PY - 1997/11/15/medline PY - 1997/11/15/entrez SP - 974 EP - 9 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 32 IS - 10 N2 - BACKGROUND: Data are limited on the value of effective antisecretory therapy in the relief of heartburn in patients without oesophagitis. METHODS: Patients with heartburn, without endoscopic signs of oesophagitis, were randomized to double-blind treatment with omeprazole, 20 or 10 mg once daily, or placebo, for 4 weeks (n = 509). Pre-treatment oesophageal acid exposure was assessed using 24-h intra-oesophageal pH monitoring. Heartburn was assessed at 2 and 4 weeks. RESULTS: At 4 weeks the proportion of patients with complete absence of heartburn was 46% (95% confidence interval, 39-53%) with 20 mg omeprazole, 31% (25-38%) with 10 mg omeprazole, and 13% (7-20%) with placebo. Satisfaction with therapy was reported by 66%, 57%, and 31% of the patients, respectively. CONCLUSION: Omeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/9361168/Heartburn_without_oesophagitis:_efficacy_of_omeprazole_therapy_and_features_determining_therapeutic_response_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365529709011212 DB - PRIME DP - Unbound Medicine ER -