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Vasectomy and prostate cancer: a case-control study in India.
Int J Epidemiol 1997; 26(5):933-8IJ

Abstract

BACKGROUND

The role of vasectomy in the development of prostate cancer remains controversial. In particular, there has been concern about detection bias and confounding in the previously published epidemiological studies examining this hypothesis. With the goal of minimizing detection bias, we have evaluated the relation between vasectomy and prostate cancer in a population without routine prostate cancer screening.

METHODS

A case-control study consisting of 175 prostate cancer cases and 978 controls with cancer diagnoses other than prostate cancer was conducted at hospitals covered by the Bombay Cancer Registry in Bombay, India. History of vasectomy, demographic, and lifestyle factors were obtained by structured interview. Multiple logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).

RESULTS

Standardizing by age, 8.7% of cases and 8.3% of controls had had a vasectomy. The OR for prostate cancer comparing men who had had a vasectomy to those who did not was 1.48 (95% CI: 0.80-2.72) controlling for age at diagnosis, smoking status, alcohol drinking, and other demographic and lifestyle factors. Risk of prostate cancer associated with vasectomy appeared to be higher among men who underwent vasectomy at least two decades prior to cancer diagnosis or who were at least 40 years old at vasectomy.

CONCLUSIONS

Although not statistically significant, the results of this hospital-based case-control study are consistent with the hypothesis of a positive association between vasectomy and prostate cancer. Because routine prostate cancer screening is not common in this population, detection bias was unlikely to account for this association.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9363512

Citation

Platz, E A., et al. "Vasectomy and Prostate Cancer: a Case-control Study in India." International Journal of Epidemiology, vol. 26, no. 5, 1997, pp. 933-8.
Platz EA, Yeole BB, Cho E, et al. Vasectomy and prostate cancer: a case-control study in India. Int J Epidemiol. 1997;26(5):933-8.
Platz, E. A., Yeole, B. B., Cho, E., Jussawalla, D. J., Giovannucci, E., & Ascherio, A. (1997). Vasectomy and prostate cancer: a case-control study in India. International Journal of Epidemiology, 26(5), pp. 933-8.
Platz EA, et al. Vasectomy and Prostate Cancer: a Case-control Study in India. Int J Epidemiol. 1997;26(5):933-8. PubMed PMID: 9363512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy and prostate cancer: a case-control study in India. AU - Platz,E A, AU - Yeole,B B, AU - Cho,E, AU - Jussawalla,D J, AU - Giovannucci,E, AU - Ascherio,A, PY - 1997/11/18/pubmed PY - 1997/11/18/medline PY - 1997/11/18/entrez KW - Asia KW - Bias KW - Biology KW - Cancer KW - Case Control Studies KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Error Sources KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - India KW - Longterm Effects KW - Male Sterilization KW - Measurement KW - Neoplasms KW - Physiology KW - Population KW - Population Dynamics KW - Prostate KW - Research Methodology KW - Research Report KW - Risk Factors KW - Southern Asia KW - Sterilization, Sexual KW - Studies KW - Time Factors KW - Urogenital System KW - Vasectomy--side effects SP - 933 EP - 8 JF - International journal of epidemiology JO - Int J Epidemiol VL - 26 IS - 5 N2 - BACKGROUND: The role of vasectomy in the development of prostate cancer remains controversial. In particular, there has been concern about detection bias and confounding in the previously published epidemiological studies examining this hypothesis. With the goal of minimizing detection bias, we have evaluated the relation between vasectomy and prostate cancer in a population without routine prostate cancer screening. METHODS: A case-control study consisting of 175 prostate cancer cases and 978 controls with cancer diagnoses other than prostate cancer was conducted at hospitals covered by the Bombay Cancer Registry in Bombay, India. History of vasectomy, demographic, and lifestyle factors were obtained by structured interview. Multiple logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Standardizing by age, 8.7% of cases and 8.3% of controls had had a vasectomy. The OR for prostate cancer comparing men who had had a vasectomy to those who did not was 1.48 (95% CI: 0.80-2.72) controlling for age at diagnosis, smoking status, alcohol drinking, and other demographic and lifestyle factors. Risk of prostate cancer associated with vasectomy appeared to be higher among men who underwent vasectomy at least two decades prior to cancer diagnosis or who were at least 40 years old at vasectomy. CONCLUSIONS: Although not statistically significant, the results of this hospital-based case-control study are consistent with the hypothesis of a positive association between vasectomy and prostate cancer. Because routine prostate cancer screening is not common in this population, detection bias was unlikely to account for this association. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/9363512/Vasectomy_and_prostate_cancer:_a_case_control_study_in_India_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/26.5.933 DB - PRIME DP - Unbound Medicine ER -