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The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography.
J Intern Med 1997; 242(4):323-8JI

Abstract

OBJECTIVES

One of the latest developments in bone densitometry is peripheral quantitative computed tomography (pQCT), a method which allows the separate determination of cortical and trabecular bone mineral density (BMD) in the peripheral skeleton. This study was designed to compare the relative abilities of single-photon absorptiometry (SPA) and pQCT to reflect BMD of the proximal femur as measured by dual-energy X-ray absorptiometry (DXA), an established predictor of osteoporotic hip fracture risk.

DESIGN

Cross-sectional study.

SUBJECTS

A well-defined community-based sample of 129 skeletally healthy women aged 70-87 years.

MEASUREMENTS

Radial BMD by SPA and pQCT and femoral BMD by DXA. Univariate and multivariate regression analyses were performed relating the DXA measurements at the femoral neck and the trochanteric region with the values of SPA and pQCT.

RESULTS

Approximately 38% of the variance in femoral neck BMD could be explained by BMD of the midradius assessed by SPA, in contrast to only 18-27% by pQCT. At the trochanter, 32% of BMD could be predicted by SPA as compared to 19-26% by pQCT. Moreover, according to multiple regression, prediction of femoral BMD by SPA was not enhanced by performing pQCT.

CONCLUSIONS

Radial pQCT has little value as a screening tool to identify elderly women with low femoral BMD. Additional research is needed to determine whether or not pQCT will enhance fracture prediction beyond that obtainable from a density measurement by SPA.

Authors+Show Affiliations

Department of Internal Medicine, Katholieke Universiteit Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9366811

Citation

Boonen, S, et al. "The Accuracy of Peripheral Skeletal Assessment at the Radius in Estimating Femoral Bone Density as Measured By Dual-energy X-ray Absorptiometry: a Comparative Study of Single-photon Absorptiometry and Computed Tomography." Journal of Internal Medicine, vol. 242, no. 4, 1997, pp. 323-8.
Boonen S, Cheng X, Nicholson PH, et al. The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography. J Intern Med. 1997;242(4):323-8.
Boonen, S., Cheng, X., Nicholson, P. H., Verbeke, G., Broos, P., & Dequeker, J. (1997). The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography. Journal of Internal Medicine, 242(4), pp. 323-8.
Boonen S, et al. The Accuracy of Peripheral Skeletal Assessment at the Radius in Estimating Femoral Bone Density as Measured By Dual-energy X-ray Absorptiometry: a Comparative Study of Single-photon Absorptiometry and Computed Tomography. J Intern Med. 1997;242(4):323-8. PubMed PMID: 9366811.
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TY - JOUR T1 - The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography. AU - Boonen,S, AU - Cheng,X, AU - Nicholson,P H, AU - Verbeke,G, AU - Broos,P, AU - Dequeker,J, PY - 1997/11/21/pubmed PY - 1997/11/21/medline PY - 1997/11/21/entrez SP - 323 EP - 8 JF - Journal of internal medicine JO - J. Intern. Med. VL - 242 IS - 4 N2 - OBJECTIVES: One of the latest developments in bone densitometry is peripheral quantitative computed tomography (pQCT), a method which allows the separate determination of cortical and trabecular bone mineral density (BMD) in the peripheral skeleton. This study was designed to compare the relative abilities of single-photon absorptiometry (SPA) and pQCT to reflect BMD of the proximal femur as measured by dual-energy X-ray absorptiometry (DXA), an established predictor of osteoporotic hip fracture risk. DESIGN: Cross-sectional study. SUBJECTS: A well-defined community-based sample of 129 skeletally healthy women aged 70-87 years. MEASUREMENTS: Radial BMD by SPA and pQCT and femoral BMD by DXA. Univariate and multivariate regression analyses were performed relating the DXA measurements at the femoral neck and the trochanteric region with the values of SPA and pQCT. RESULTS: Approximately 38% of the variance in femoral neck BMD could be explained by BMD of the midradius assessed by SPA, in contrast to only 18-27% by pQCT. At the trochanter, 32% of BMD could be predicted by SPA as compared to 19-26% by pQCT. Moreover, according to multiple regression, prediction of femoral BMD by SPA was not enhanced by performing pQCT. CONCLUSIONS: Radial pQCT has little value as a screening tool to identify elderly women with low femoral BMD. Additional research is needed to determine whether or not pQCT will enhance fracture prediction beyond that obtainable from a density measurement by SPA. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/9366811/The_accuracy_of_peripheral_skeletal_assessment_at_the_radius_in_estimating_femoral_bone_density_as_measured_by_dual_energy_X_ray_absorptiometry:_a_comparative_study_of_single_photon_absorptiometry_and_computed_tomography_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1997&volume=242&issue=4&spage=323 DB - PRIME DP - Unbound Medicine ER -