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Different Babesia canis isolates, different diseases.
Parasitology. 1997 Nov; 115 (Pt 5):485-93.P

Abstract

Using surface immunofluorescence isolate-specific antigens were detected on the membrane of erythrocytes infected with Babesia parasites. In addition, the strains reacted differently with Plasmagel in that the European isolate (B.c. canis) could be purified on Plasmagel effectively, whereas infected erythrocytes of the South-African isolate (B.c. rossi) could not. Experimental infection of dogs with Babesia canis isolates from geographically different areas revealed different pathology. The European isolate obtained from France exhibited transient parasitaemia, usually below 1%, associated with low PCV values and congestion of internal organs. Clinical disease was correlated with an effect on the coagulation system, and not with peripheral parasitaemia. Infection of dogs with South-African-derived isolate induced high parasitaemia usually much higher than 1%, which required chemotherapeutic treatment. In these animals clinical disease was correlated with peripheral parasitaemia and not with parameters of the coagulation system. The results show that the etiology of disease caused by these isolates of B.c. canis and B.c. rossi is different. This might have implications for the development of vaccines against these infections.

Authors+Show Affiliations

Department of Parasitology, Intervet International BV, Boxmeer, The Netherlands. parasitology@intervet.akzo.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9368899

Citation

Schetters, T P., et al. "Different Babesia Canis Isolates, Different Diseases." Parasitology, vol. 115 (Pt 5), 1997, pp. 485-93.
Schetters TP, Moubri K, Précigout E, et al. Different Babesia canis isolates, different diseases. Parasitology. 1997;115 (Pt 5):485-93.
Schetters, T. P., Moubri, K., Précigout, E., Kleuskens, J., Scholtes, N. C., & Gorenflot, A. (1997). Different Babesia canis isolates, different diseases. Parasitology, 115 (Pt 5), 485-93.
Schetters TP, et al. Different Babesia Canis Isolates, Different Diseases. Parasitology. 1997;115 (Pt 5):485-93. PubMed PMID: 9368899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different Babesia canis isolates, different diseases. AU - Schetters,T P, AU - Moubri,K, AU - Précigout,E, AU - Kleuskens,J, AU - Scholtes,N C, AU - Gorenflot,A, PY - 1997/11/22/pubmed PY - 1997/11/22/medline PY - 1997/11/22/entrez SP - 485 EP - 93 JF - Parasitology JO - Parasitology VL - 115 (Pt 5) N2 - Using surface immunofluorescence isolate-specific antigens were detected on the membrane of erythrocytes infected with Babesia parasites. In addition, the strains reacted differently with Plasmagel in that the European isolate (B.c. canis) could be purified on Plasmagel effectively, whereas infected erythrocytes of the South-African isolate (B.c. rossi) could not. Experimental infection of dogs with Babesia canis isolates from geographically different areas revealed different pathology. The European isolate obtained from France exhibited transient parasitaemia, usually below 1%, associated with low PCV values and congestion of internal organs. Clinical disease was correlated with an effect on the coagulation system, and not with peripheral parasitaemia. Infection of dogs with South-African-derived isolate induced high parasitaemia usually much higher than 1%, which required chemotherapeutic treatment. In these animals clinical disease was correlated with peripheral parasitaemia and not with parameters of the coagulation system. The results show that the etiology of disease caused by these isolates of B.c. canis and B.c. rossi is different. This might have implications for the development of vaccines against these infections. SN - 0031-1820 UR - https://www.unboundmedicine.com/medline/citation/9368899/Different_Babesia_canis_isolates,_different_diseases L2 - https://www.lens.org/lens/search?q=citation_id:9368899 DB - PRIME DP - Unbound Medicine ER -