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[Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord].
Masui. 1997 Oct; 46(10):1354-61.M

Abstract

Spinal NMDA receptors are involved in hyperalgesia and chronic pain. The activation of spinal NMDA receptor results in the production of nitric oxide in the second order neurons in the spinal cord dorsal horn. We investigated the effects of intrathecally administered nitroglycerin (NTG) which releases nitric oxide in the cell. Formalin test which reflects phasic and tonic nociception was used as a nociceptive measure in rats with chronically implanted intrathecal catheters. Intrathecal injection of NTG resulted in the increase of flinching behavior induced by formalin injection to one paw in phase 1 (phasic) and phase 2 (tonic) responses in a dose-dependent manner. Intrathecally administered NMDA antagonist, MK-801 (MK) dose-dependently inhibited the effect of NTG but the effect was significant only in the phase 2 of the formalin test. MK given after formalin injection had significantly less effect on the phase 2 response. L-NAME (NOS inhibitor), MB (guanylate cyclase inhibitor) and HB (nitric oxide scavenger) significantly antagonized the hyperalgesic effect of NTG in the phase 2 of the formalin test. These results show that nitric oxide plays an important role in producing hyperalgesia in the spinal cord acting postsynaptically as well as pre-synaptically.

Authors+Show Affiliations

Takano Y
Department of Anesthesiology, Koshigaya Hospital, Dokkyo University, School of Medicine.
Kuno Y
No affiliation info available
Sato E
No affiliation info available
Takano M
No affiliation info available
Sato I
No affiliation info available

MeSH

AnimalsDizocilpine MaleateDose-Response Relationship, DrugHyperalgesiaMaleNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseNitroglycerinRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSpinal CordVasodilator Agents

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

jpn

PubMed ID

9369051

Citation

Takano, Y, et al. "[Hyperalgesia Induced By Intrathecal Administration of Nitroglycerin Involves NMDA Receptor Activation in the Spinal Cord]." Masui. the Japanese Journal of Anesthesiology, vol. 46, no. 10, 1997, pp. 1354-61.
Takano Y, Kuno Y, Sato E, et al. [Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord]. Masui. 1997;46(10):1354-61.
Takano, Y., Kuno, Y., Sato, E., Takano, M., & Sato, I. (1997). [Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord]. Masui. the Japanese Journal of Anesthesiology, 46(10), 1354-61.
Takano Y, et al. [Hyperalgesia Induced By Intrathecal Administration of Nitroglycerin Involves NMDA Receptor Activation in the Spinal Cord]. Masui. 1997;46(10):1354-61. PubMed PMID: 9369051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord]. AU - Takano,Y, AU - Kuno,Y, AU - Sato,E, AU - Takano,M, AU - Sato,I, PY - 1997/11/22/pubmed PY - 1997/11/22/medline PY - 1997/11/22/entrez SP - 1354 EP - 61 JF - Masui. The Japanese journal of anesthesiology JO - Masui VL - 46 IS - 10 N2 - Spinal NMDA receptors are involved in hyperalgesia and chronic pain. The activation of spinal NMDA receptor results in the production of nitric oxide in the second order neurons in the spinal cord dorsal horn. We investigated the effects of intrathecally administered nitroglycerin (NTG) which releases nitric oxide in the cell. Formalin test which reflects phasic and tonic nociception was used as a nociceptive measure in rats with chronically implanted intrathecal catheters. Intrathecal injection of NTG resulted in the increase of flinching behavior induced by formalin injection to one paw in phase 1 (phasic) and phase 2 (tonic) responses in a dose-dependent manner. Intrathecally administered NMDA antagonist, MK-801 (MK) dose-dependently inhibited the effect of NTG but the effect was significant only in the phase 2 of the formalin test. MK given after formalin injection had significantly less effect on the phase 2 response. L-NAME (NOS inhibitor), MB (guanylate cyclase inhibitor) and HB (nitric oxide scavenger) significantly antagonized the hyperalgesic effect of NTG in the phase 2 of the formalin test. These results show that nitric oxide plays an important role in producing hyperalgesia in the spinal cord acting postsynaptically as well as pre-synaptically. SN - 0021-4892 UR - https://www.unboundmedicine.com/medline/citation/9369051/[Hyperalgesia_induced_by_intrathecal_administration_of_nitroglycerin_involves_NMDA_receptor_activation_in_the_spinal_cord]_ DB - PRIME DP - Unbound Medicine ER -