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[Apolipoprotein E genotype as a risk factor in Japanese patients with early-onset and late-onset Alzheimer's disease].
Seishin Shinkeigaku Zasshi 1997; 99(8):575-87SS

Abstract

Recent studies have provided evidence of an association of apolipoprotein E (apoE) epsilon 4 allele and late-onset sporadic Alzheimer's disease (AD). Some studies have shown the possibility that apoE epsilon 4 is a risk factor of developing AD in early-onset type. We have analyzed the apoE gene polymorphism in a sample of 310 Japanese AD subjects and 237 age-matched Japanese controls. We divided the sporadic AD patients into two subgroups of 237 late-onset (> 65 years) and 73 early-onset (< or = 65 years) patients, and into three subgroups according to their apoE genotype, no epsilon 4, one epsilon 4, and two epsilon 4 alleles. Our data confirmed an association between epsilon 4 allele and early-onset AD and late-onset AD. The odds ratios (95% confidence interval) referred to no epsilon 4 allele for AD were 3.4 (1.7-7.0) for one epsilon 4 allele and 20.3 (2.5-166.6) for two epsilon 4 alleles in early-onset type, and 6.7 (3.9-11.3) for one epsilon 4 allele and 19.0 (2.5-145.6) for two epsilon 4 alleles in late-onset type. These ratios were significantly increased in both early-onset AD and late-onset AD. Kaplan-Meier survival analysis, which estimates the age of onset for subjects with no, one, and two epsilon 4 alleles in early-onset and late-onset type, revealed a significant dose effect where each additional epsilon 4 allele made the age of onset earlier (p < 0.0001). The age of onset is 9.7 years earlier for two epsilon 4 bearers and 3.9 years earlier for one epsilon 4 bearers than no epsilon 4 bearers in late-onset AD, 2.9 years earlier for two epsilon 4 bearers and 1.4 years earlier for one epsilon 4 bearers than no epsilon 4 bearers in early-onset AD. Moreover, we studied an association between apoE epsilon 2 allele and early-onset AD and late-onset AD. There was a significantly decreased frequency of apoE epsilon 2 allele in patients with late-onset AD (p = 0.026), although the frequency of apoE epsilon 2 was not changed significantly in early-onset AD (p = 0.360). The odds ratios referred to no epsilon 2 allele for AD were 1.9 (0.6-5.7) for one epsilon 2 allele in early-onset type, and 0.4 (0.2-0.9) for one epsilon 2 allele in late-onset type. Our study suggested the difference in the effect of apoE genotype on developing AD between early-onset and late-onset type in Japanese patients.

Authors+Show Affiliations

Department of Psychiatry and Neurology, Kobe University School of Medicine.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

9369084

Citation

Shimada, K, et al. "[Apolipoprotein E Genotype as a Risk Factor in Japanese Patients With Early-onset and Late-onset Alzheimer's Disease]." Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica, vol. 99, no. 8, 1997, pp. 575-87.
Shimada K, Yasuda M, Maeda K. [Apolipoprotein E genotype as a risk factor in Japanese patients with early-onset and late-onset Alzheimer's disease]. Seishin Shinkeigaku Zasshi. 1997;99(8):575-87.
Shimada, K., Yasuda, M., & Maeda, K. (1997). [Apolipoprotein E genotype as a risk factor in Japanese patients with early-onset and late-onset Alzheimer's disease]. Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica, 99(8), pp. 575-87.
Shimada K, Yasuda M, Maeda K. [Apolipoprotein E Genotype as a Risk Factor in Japanese Patients With Early-onset and Late-onset Alzheimer's Disease]. Seishin Shinkeigaku Zasshi. 1997;99(8):575-87. PubMed PMID: 9369084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Apolipoprotein E genotype as a risk factor in Japanese patients with early-onset and late-onset Alzheimer's disease]. AU - Shimada,K, AU - Yasuda,M, AU - Maeda,K, PY - 1997/1/1/pubmed PY - 1997/11/22/medline PY - 1997/1/1/entrez SP - 575 EP - 87 JF - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica JO - Seishin Shinkeigaku Zasshi VL - 99 IS - 8 N2 - Recent studies have provided evidence of an association of apolipoprotein E (apoE) epsilon 4 allele and late-onset sporadic Alzheimer's disease (AD). Some studies have shown the possibility that apoE epsilon 4 is a risk factor of developing AD in early-onset type. We have analyzed the apoE gene polymorphism in a sample of 310 Japanese AD subjects and 237 age-matched Japanese controls. We divided the sporadic AD patients into two subgroups of 237 late-onset (> 65 years) and 73 early-onset (< or = 65 years) patients, and into three subgroups according to their apoE genotype, no epsilon 4, one epsilon 4, and two epsilon 4 alleles. Our data confirmed an association between epsilon 4 allele and early-onset AD and late-onset AD. The odds ratios (95% confidence interval) referred to no epsilon 4 allele for AD were 3.4 (1.7-7.0) for one epsilon 4 allele and 20.3 (2.5-166.6) for two epsilon 4 alleles in early-onset type, and 6.7 (3.9-11.3) for one epsilon 4 allele and 19.0 (2.5-145.6) for two epsilon 4 alleles in late-onset type. These ratios were significantly increased in both early-onset AD and late-onset AD. Kaplan-Meier survival analysis, which estimates the age of onset for subjects with no, one, and two epsilon 4 alleles in early-onset and late-onset type, revealed a significant dose effect where each additional epsilon 4 allele made the age of onset earlier (p < 0.0001). The age of onset is 9.7 years earlier for two epsilon 4 bearers and 3.9 years earlier for one epsilon 4 bearers than no epsilon 4 bearers in late-onset AD, 2.9 years earlier for two epsilon 4 bearers and 1.4 years earlier for one epsilon 4 bearers than no epsilon 4 bearers in early-onset AD. Moreover, we studied an association between apoE epsilon 2 allele and early-onset AD and late-onset AD. There was a significantly decreased frequency of apoE epsilon 2 allele in patients with late-onset AD (p = 0.026), although the frequency of apoE epsilon 2 was not changed significantly in early-onset AD (p = 0.360). The odds ratios referred to no epsilon 2 allele for AD were 1.9 (0.6-5.7) for one epsilon 2 allele in early-onset type, and 0.4 (0.2-0.9) for one epsilon 2 allele in late-onset type. Our study suggested the difference in the effect of apoE genotype on developing AD between early-onset and late-onset type in Japanese patients. SN - 0033-2658 UR - https://www.unboundmedicine.com/medline/citation/9369084/[Apolipoprotein_E_genotype_as_a_risk_factor_in_Japanese_patients_with_early_onset_and_late_onset_Alzheimer's_disease]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -