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Fulminant amebic colitis: analysis of 55 cases.
Dis Colon Rectum. 1997 Nov; 40(11):1362-7.DC

Abstract

Fulminant amebic colitis is a rare disease with high morbidity and mortality.

PURPOSE

This study was designed to identify the most frequent clinical and histopathologic features of fulminant amebic colitis and to analyze results of surgical treatment and the existence of risk factors for mortality.

MATERIALS AND METHODS

A retrospective analysis was conducted of clinical and histopathologic data of 55 patients with fulminant amebic colitis. Data were obtained from the files of autopsies and surgical operations that had been performed at a referral center in Mexico from 1943 through 1994.

RESULTS

Median age was 52 (range, 18-79) years. There were 34 men (62 percent) and 21 women (38 percent). Diabetes mellitus and chronic alcoholism were the most frequent diseases in association with fulminant amebic colitis (40 and 31 percent, respectively). The most frequent clinical manifestations were abdominal pain, diarrhea, rectal bleeding, and fever. There was a coexistent amebic liver abscess in 54 percent of patients. The main histopathologic characteristics were necrosis, presence of trophozoites, and acute and/or chronic inflammation. Of 25 patients who underwent surgery, only six survived (operative mortality, 76 percent; overall mortality, 89 percent). The variables that correlated with mortality were longer duration of symptoms, lower count of leukocytes, nonsurgical treatment, nonresective surgical procedure, hospital admission before 1971, and invasion of trophozoites into or through the muscularis.

CONCLUSIONS

The results may help to obtain an earlier diagnosis and establish proper treatment of fulminant amebic colitis.

Authors+Show Affiliations

Department of Surgery, Instituto Nacional de la Nutricion Salvador Zubiran, Mexico City, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9369114

Citation

Takahashi, T, et al. "Fulminant Amebic Colitis: Analysis of 55 Cases." Diseases of the Colon and Rectum, vol. 40, no. 11, 1997, pp. 1362-7.
Takahashi T, Gamboa-Dominguez A, Gomez-Mendez TJ, et al. Fulminant amebic colitis: analysis of 55 cases. Dis Colon Rectum. 1997;40(11):1362-7.
Takahashi, T., Gamboa-Dominguez, A., Gomez-Mendez, T. J., Remes, J. M., Rembis, V., Martinez-Gonzalez, D., Gutierrez-Saldivar, J., Morales, J. C., Granados, J., & Sierra-Madero, J. (1997). Fulminant amebic colitis: analysis of 55 cases. Diseases of the Colon and Rectum, 40(11), 1362-7.
Takahashi T, et al. Fulminant Amebic Colitis: Analysis of 55 Cases. Dis Colon Rectum. 1997;40(11):1362-7. PubMed PMID: 9369114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fulminant amebic colitis: analysis of 55 cases. AU - Takahashi,T, AU - Gamboa-Dominguez,A, AU - Gomez-Mendez,T J, AU - Remes,J M, AU - Rembis,V, AU - Martinez-Gonzalez,D, AU - Gutierrez-Saldivar,J, AU - Morales,J C, AU - Granados,J, AU - Sierra-Madero,J, PY - 1997/11/22/pubmed PY - 1997/11/22/medline PY - 1997/11/22/entrez SP - 1362 EP - 7 JF - Diseases of the colon and rectum JO - Dis Colon Rectum VL - 40 IS - 11 N2 - UNLABELLED: Fulminant amebic colitis is a rare disease with high morbidity and mortality. PURPOSE: This study was designed to identify the most frequent clinical and histopathologic features of fulminant amebic colitis and to analyze results of surgical treatment and the existence of risk factors for mortality. MATERIALS AND METHODS: A retrospective analysis was conducted of clinical and histopathologic data of 55 patients with fulminant amebic colitis. Data were obtained from the files of autopsies and surgical operations that had been performed at a referral center in Mexico from 1943 through 1994. RESULTS: Median age was 52 (range, 18-79) years. There were 34 men (62 percent) and 21 women (38 percent). Diabetes mellitus and chronic alcoholism were the most frequent diseases in association with fulminant amebic colitis (40 and 31 percent, respectively). The most frequent clinical manifestations were abdominal pain, diarrhea, rectal bleeding, and fever. There was a coexistent amebic liver abscess in 54 percent of patients. The main histopathologic characteristics were necrosis, presence of trophozoites, and acute and/or chronic inflammation. Of 25 patients who underwent surgery, only six survived (operative mortality, 76 percent; overall mortality, 89 percent). The variables that correlated with mortality were longer duration of symptoms, lower count of leukocytes, nonsurgical treatment, nonresective surgical procedure, hospital admission before 1971, and invasion of trophozoites into or through the muscularis. CONCLUSIONS: The results may help to obtain an earlier diagnosis and establish proper treatment of fulminant amebic colitis. SN - 0012-3706 UR - https://www.unboundmedicine.com/medline/citation/9369114/Fulminant_amebic_colitis:_analysis_of_55_cases_ L2 - http://link.springer.com/article/10.1007/BF02050824 DB - PRIME DP - Unbound Medicine ER -