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Risk factors for developing multiple sclerosis after childhood optic neuritis.

Abstract

We reviewed the records of all children (younger than 16 years of age) who presented with a diagnosis of optic neuritis (ON) identified through the comprehensive records-linkage system at the Mayo Clinic and identified 94 cases between 1950 and 1988 with a documented history of idiopathic ON. Detailed follow-up information was available on 79 patients, with a median length of follow-up of 19.4 years. Life-table analysis showed that 13% of the 79 patients with isolated ON had progressed to clinically or laboratory-supported definite multiple sclerosis (MS) by 10 years of follow-up, 19% by 20 years, 22% by 30 years, and 26% by 40 years. Gender, age, funduscopic findings, visual acuity, or family history of either ON or MS did not predict the development of MS. The presence of bilateral sequential or recurrent ON increased the risk of developing MS (p = 0.002; hazard ratio = 5.09), whereas the presence of infection within 2 weeks before the onset of ON decreased the risk of developing MS (p = 0.060; hazard ratio = 0.24). This study of childhood ON supports the lower risk of recurrence and progression to MS compared with adults.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Mayo Clinic, Rochester, MN, USA.

    , , , , , ,

    Source

    Neurology 49:5 1997 Nov pg 1413-8

    MeSH

    Adolescent
    Adult
    Age Factors
    Child
    Child, Preschool
    Cohort Studies
    Female
    Follow-Up Studies
    Humans
    Male
    Multiple Sclerosis
    Optic Neuritis
    Retrospective Studies
    Risk Factors
    Time Factors
    Vision Tests
    Visual Fields

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    9371931

    Citation

    Lucchinetti, C F., et al. "Risk Factors for Developing Multiple Sclerosis After Childhood Optic Neuritis." Neurology, vol. 49, no. 5, 1997, pp. 1413-8.
    Lucchinetti CF, Kiers L, O'Duffy A, et al. Risk factors for developing multiple sclerosis after childhood optic neuritis. Neurology. 1997;49(5):1413-8.
    Lucchinetti, C. F., Kiers, L., O'Duffy, A., Gomez, M. R., Cross, S., Leavitt, J. A., ... Rodriguez, M. (1997). Risk factors for developing multiple sclerosis after childhood optic neuritis. Neurology, 49(5), pp. 1413-8.
    Lucchinetti CF, et al. Risk Factors for Developing Multiple Sclerosis After Childhood Optic Neuritis. Neurology. 1997;49(5):1413-8. PubMed PMID: 9371931.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk factors for developing multiple sclerosis after childhood optic neuritis. AU - Lucchinetti,C F, AU - Kiers,L, AU - O'Duffy,A, AU - Gomez,M R, AU - Cross,S, AU - Leavitt,J A, AU - O'Brien,P, AU - Rodriguez,M, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez SP - 1413 EP - 8 JF - Neurology JO - Neurology VL - 49 IS - 5 N2 - We reviewed the records of all children (younger than 16 years of age) who presented with a diagnosis of optic neuritis (ON) identified through the comprehensive records-linkage system at the Mayo Clinic and identified 94 cases between 1950 and 1988 with a documented history of idiopathic ON. Detailed follow-up information was available on 79 patients, with a median length of follow-up of 19.4 years. Life-table analysis showed that 13% of the 79 patients with isolated ON had progressed to clinically or laboratory-supported definite multiple sclerosis (MS) by 10 years of follow-up, 19% by 20 years, 22% by 30 years, and 26% by 40 years. Gender, age, funduscopic findings, visual acuity, or family history of either ON or MS did not predict the development of MS. The presence of bilateral sequential or recurrent ON increased the risk of developing MS (p = 0.002; hazard ratio = 5.09), whereas the presence of infection within 2 weeks before the onset of ON decreased the risk of developing MS (p = 0.060; hazard ratio = 0.24). This study of childhood ON supports the lower risk of recurrence and progression to MS compared with adults. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/9371931/Risk_factors_for_developing_multiple_sclerosis_after_childhood_optic_neuritis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9371931.ui DB - PRIME DP - Unbound Medicine ER -