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Risk factors for developing multiple sclerosis after childhood optic neuritis.
Neurology 1997; 49(5):1413-8Neur

Abstract

We reviewed the records of all children (younger than 16 years of age) who presented with a diagnosis of optic neuritis (ON) identified through the comprehensive records-linkage system at the Mayo Clinic and identified 94 cases between 1950 and 1988 with a documented history of idiopathic ON. Detailed follow-up information was available on 79 patients, with a median length of follow-up of 19.4 years. Life-table analysis showed that 13% of the 79 patients with isolated ON had progressed to clinically or laboratory-supported definite multiple sclerosis (MS) by 10 years of follow-up, 19% by 20 years, 22% by 30 years, and 26% by 40 years. Gender, age, funduscopic findings, visual acuity, or family history of either ON or MS did not predict the development of MS. The presence of bilateral sequential or recurrent ON increased the risk of developing MS (p = 0.002; hazard ratio = 5.09), whereas the presence of infection within 2 weeks before the onset of ON decreased the risk of developing MS (p = 0.060; hazard ratio = 0.24). This study of childhood ON supports the lower risk of recurrence and progression to MS compared with adults.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic, Rochester, MN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9371931

Citation

Lucchinetti, C F., et al. "Risk Factors for Developing Multiple Sclerosis After Childhood Optic Neuritis." Neurology, vol. 49, no. 5, 1997, pp. 1413-8.
Lucchinetti CF, Kiers L, O'Duffy A, et al. Risk factors for developing multiple sclerosis after childhood optic neuritis. Neurology. 1997;49(5):1413-8.
Lucchinetti, C. F., Kiers, L., O'Duffy, A., Gomez, M. R., Cross, S., Leavitt, J. A., ... Rodriguez, M. (1997). Risk factors for developing multiple sclerosis after childhood optic neuritis. Neurology, 49(5), pp. 1413-8.
Lucchinetti CF, et al. Risk Factors for Developing Multiple Sclerosis After Childhood Optic Neuritis. Neurology. 1997;49(5):1413-8. PubMed PMID: 9371931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for developing multiple sclerosis after childhood optic neuritis. AU - Lucchinetti,C F, AU - Kiers,L, AU - O'Duffy,A, AU - Gomez,M R, AU - Cross,S, AU - Leavitt,J A, AU - O'Brien,P, AU - Rodriguez,M, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez SP - 1413 EP - 8 JF - Neurology JO - Neurology VL - 49 IS - 5 N2 - We reviewed the records of all children (younger than 16 years of age) who presented with a diagnosis of optic neuritis (ON) identified through the comprehensive records-linkage system at the Mayo Clinic and identified 94 cases between 1950 and 1988 with a documented history of idiopathic ON. Detailed follow-up information was available on 79 patients, with a median length of follow-up of 19.4 years. Life-table analysis showed that 13% of the 79 patients with isolated ON had progressed to clinically or laboratory-supported definite multiple sclerosis (MS) by 10 years of follow-up, 19% by 20 years, 22% by 30 years, and 26% by 40 years. Gender, age, funduscopic findings, visual acuity, or family history of either ON or MS did not predict the development of MS. The presence of bilateral sequential or recurrent ON increased the risk of developing MS (p = 0.002; hazard ratio = 5.09), whereas the presence of infection within 2 weeks before the onset of ON decreased the risk of developing MS (p = 0.060; hazard ratio = 0.24). This study of childhood ON supports the lower risk of recurrence and progression to MS compared with adults. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/9371931/Risk_factors_for_developing_multiple_sclerosis_after_childhood_optic_neuritis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9371931.ui DB - PRIME DP - Unbound Medicine ER -