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Dopamine receptor-mediated regulation of expression of Fos and its related antigens (FRA) in somatostatin neurons in the hypothalamic periventricular nucleus.
Brain Res. 1997 Oct 03; 770(1-2):176-83.BR

Abstract

Somatostatin (SS)-containing perikarya located within the hypothalamic periventricular nucleus (PeVN) comprise a heterogenous population of neurons with both local intrahypothalamic and distant extrahypothalamic axonal projection sites. The close proximity of SS perikarya and their dendrites to dopaminergic (DA) neuronal processes in the PeVN suggests that these peptidergic neurons may be regulated by DA receptor-mediated mechanisms. To test this, the effects of the D1 agonist SKF 38393 and D2/3 agonist quinelorane were examined on expression of the immediate early gene products Fos and its related antigens (FRA) in SS-immunoreactive (IR) neurons in the PeVN. SS-IR neurons were located in the most medial portion of the PeVN bordered medially by the third ventricle and laterally by tyrosine hydroxylase (TH)-IR neurons. In control rats, 10-15% of all SS-IR neurons contained FRA-IR. Activation of D1 receptors with SKF 38393 had no effect on either the total number of SS-IR neurons or the number of SS-IR neurons containing FRA-IR. In contrast, activation of D2/3 receptors with quinelorane decreased the number of SS-IR neurons containing FRA-IR, without affecting the total number of SS-IR neurons. The D2/3 antagonist raclopride had no effect per se, but prevented the quinelorane-induced decrease in the number of SS neurons expressing FRA-IR. These results reveal that activation of D2/3 (but not D1) receptors inhibits expression of the immediate early gene products FRA in SS-containing neurons in the PeVN, but expression of FRA in SS neurons is not tonically inhibited by dopamine acting on D2/3 receptors.

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Authors+Show Affiliations

Cheung S
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317, USA. cheungs@pilot.msu.edu
Johnson JD
No affiliation info available
Moore KE
No affiliation info available
Lookingland KJ
No affiliation info available

MeSH

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsDopamine AgonistsDopamine AntagonistsImmunohistochemistryMaleNeuronsParaventricular Hypothalamic NucleusProto-Oncogene Proteins c-fosQuinolinesRacloprideRatsRats, Inbred StrainsReceptors, Dopamine D1Receptors, Dopamine D2SalicylamidesSomatostatin

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9372217

Citation

Cheung, S, et al. "Dopamine Receptor-mediated Regulation of Expression of Fos and Its Related Antigens (FRA) in Somatostatin Neurons in the Hypothalamic Periventricular Nucleus." Brain Research, vol. 770, no. 1-2, 1997, pp. 176-83.
Cheung S, Johnson JD, Moore KE, et al. Dopamine receptor-mediated regulation of expression of Fos and its related antigens (FRA) in somatostatin neurons in the hypothalamic periventricular nucleus. Brain Res. 1997;770(1-2):176-83.
Cheung, S., Johnson, J. D., Moore, K. E., & Lookingland, K. J. (1997). Dopamine receptor-mediated regulation of expression of Fos and its related antigens (FRA) in somatostatin neurons in the hypothalamic periventricular nucleus. Brain Research, 770(1-2), 176-83.
Cheung S, et al. Dopamine Receptor-mediated Regulation of Expression of Fos and Its Related Antigens (FRA) in Somatostatin Neurons in the Hypothalamic Periventricular Nucleus. Brain Res. 1997 Oct 3;770(1-2):176-83. PubMed PMID: 9372217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine receptor-mediated regulation of expression of Fos and its related antigens (FRA) in somatostatin neurons in the hypothalamic periventricular nucleus. AU - Cheung,S, AU - Johnson,J D, AU - Moore,K E, AU - Lookingland,K J, PY - 1998/1/24/pubmed PY - 1998/1/24/medline PY - 1998/1/24/entrez SP - 176 EP - 83 JF - Brain research JO - Brain Res VL - 770 IS - 1-2 N2 - Somatostatin (SS)-containing perikarya located within the hypothalamic periventricular nucleus (PeVN) comprise a heterogenous population of neurons with both local intrahypothalamic and distant extrahypothalamic axonal projection sites. The close proximity of SS perikarya and their dendrites to dopaminergic (DA) neuronal processes in the PeVN suggests that these peptidergic neurons may be regulated by DA receptor-mediated mechanisms. To test this, the effects of the D1 agonist SKF 38393 and D2/3 agonist quinelorane were examined on expression of the immediate early gene products Fos and its related antigens (FRA) in SS-immunoreactive (IR) neurons in the PeVN. SS-IR neurons were located in the most medial portion of the PeVN bordered medially by the third ventricle and laterally by tyrosine hydroxylase (TH)-IR neurons. In control rats, 10-15% of all SS-IR neurons contained FRA-IR. Activation of D1 receptors with SKF 38393 had no effect on either the total number of SS-IR neurons or the number of SS-IR neurons containing FRA-IR. In contrast, activation of D2/3 receptors with quinelorane decreased the number of SS-IR neurons containing FRA-IR, without affecting the total number of SS-IR neurons. The D2/3 antagonist raclopride had no effect per se, but prevented the quinelorane-induced decrease in the number of SS neurons expressing FRA-IR. These results reveal that activation of D2/3 (but not D1) receptors inhibits expression of the immediate early gene products FRA in SS-containing neurons in the PeVN, but expression of FRA in SS neurons is not tonically inhibited by dopamine acting on D2/3 receptors. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/9372217/Dopamine_receptor_mediated_regulation_of_expression_of_Fos_and_its_related_antigens__FRA__in_somatostatin_neurons_in_the_hypothalamic_periventricular_nucleus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(97)00781-6 DB - PRIME DP - Unbound Medicine ER -