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Giant cell granulomatous pulmonary and myocardial lesions in necrobiotic xanthogranuloma with paraproteinemia.
Mayo Clin Proc. 1997 Nov; 72(11):1028-33.MC

Abstract

OBJECTIVE

To report three cases of pulmonary or myocardial disease (or both) and necrobiotic xanthogranuloma.

MATERIAL AND METHODS

Giant cell granulomas of the lung and myocardium were demonstrated in three patients who had pulmonary and myocardial lesions of necrobiotic xanthogranuloma in conjunction with skin lesions, leukopenia, paraproteinemia, and complement deficiencies. The patients were two men who were 47 and 64 years of age and a 39-year-old woman.

RESULTS

Biopsies of skin and visceral lesions showed asteroid and cytoplasmic inclusions. B-cell lymphoid nodules were found. In one of the male patients, a major clonal T-cell receptor gene rearrangement was detected in the peripheral blood. Prednisone was ineffective in two of the patients. The other patient experienced regression of skin lesions and diminishment of a chest nodule after receiving alkylating agent therapy.

CONCLUSION

Establishing the correct diagnosis is important, and apparently it is possible to establish the nature of the myocardial and pulmonary lesions with use of appropriate scans and by biopsy. Successful treatment of necrobiotic xanthogranuloma skin lesions with corticosteroids or alkylating agents (or both) implies that evolution of serious disease that compromises the heart and lungs could be controlled.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic Scottsdale, Arizona, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9374976

Citation

Winkelmann, R K., et al. "Giant Cell Granulomatous Pulmonary and Myocardial Lesions in Necrobiotic Xanthogranuloma With Paraproteinemia." Mayo Clinic Proceedings, vol. 72, no. 11, 1997, pp. 1028-33.
Winkelmann RK, Litzow MR, Umbert IJ, et al. Giant cell granulomatous pulmonary and myocardial lesions in necrobiotic xanthogranuloma with paraproteinemia. Mayo Clin Proc. 1997;72(11):1028-33.
Winkelmann, R. K., Litzow, M. R., Umbert, I. J., & Lie, J. T. (1997). Giant cell granulomatous pulmonary and myocardial lesions in necrobiotic xanthogranuloma with paraproteinemia. Mayo Clinic Proceedings, 72(11), 1028-33.
Winkelmann RK, et al. Giant Cell Granulomatous Pulmonary and Myocardial Lesions in Necrobiotic Xanthogranuloma With Paraproteinemia. Mayo Clin Proc. 1997;72(11):1028-33. PubMed PMID: 9374976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Giant cell granulomatous pulmonary and myocardial lesions in necrobiotic xanthogranuloma with paraproteinemia. AU - Winkelmann,R K, AU - Litzow,M R, AU - Umbert,I J, AU - Lie,J T, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez SP - 1028 EP - 33 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 72 IS - 11 N2 - OBJECTIVE: To report three cases of pulmonary or myocardial disease (or both) and necrobiotic xanthogranuloma. MATERIAL AND METHODS: Giant cell granulomas of the lung and myocardium were demonstrated in three patients who had pulmonary and myocardial lesions of necrobiotic xanthogranuloma in conjunction with skin lesions, leukopenia, paraproteinemia, and complement deficiencies. The patients were two men who were 47 and 64 years of age and a 39-year-old woman. RESULTS: Biopsies of skin and visceral lesions showed asteroid and cytoplasmic inclusions. B-cell lymphoid nodules were found. In one of the male patients, a major clonal T-cell receptor gene rearrangement was detected in the peripheral blood. Prednisone was ineffective in two of the patients. The other patient experienced regression of skin lesions and diminishment of a chest nodule after receiving alkylating agent therapy. CONCLUSION: Establishing the correct diagnosis is important, and apparently it is possible to establish the nature of the myocardial and pulmonary lesions with use of appropriate scans and by biopsy. Successful treatment of necrobiotic xanthogranuloma skin lesions with corticosteroids or alkylating agents (or both) implies that evolution of serious disease that compromises the heart and lungs could be controlled. SN - 0025-6196 UR - https://www.unboundmedicine.com/medline/citation/9374976/Giant_cell_granulomatous_pulmonary_and_myocardial_lesions_in_necrobiotic_xanthogranuloma_with_paraproteinemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(11)63542-8 DB - PRIME DP - Unbound Medicine ER -