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Color Doppler ultrasound measurements after topical and retrobulbar epinephrine in primate eyes.
Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2655-61.IO

Abstract

PURPOSE

To determine the effects of topical epinephrine and retrobulbar anesthesia containing lidocaine with epinephrine on retrobulbar hemodynamic measurements in the primate eye, using color Doppler ultrasound.

METHODS

Color Doppler ultrasound measurements were performed at baseline and 90 minutes after masked administration of topical 2% epinephrine or balanced salt solution to six cynomolgus monkeys. Measurements were also performed at baseline and 30 minutes after retrobulbar injection of 2% lidocaine, with or without 1:200,000 epinephrine.

RESULTS

After topical epinephrine, color Doppler ultrasound measurements were not significantly different compared with baseline measurements in the central retinal artery, posterior ciliary arteries, and superior ophthalmic vein. There were decreased systolic and diastolic velocities in the ophthalmic artery (P < 0.03 and P < 0.02, respectively) after topical epinephrine; however, Pourcelot's ratio (resistive index) was not significantly different compared with that at baseline. In contrast, there were marked changes in the retrobulbar arterial circulation after retrobulbar injection of lidocaine with epinephrine. The systolic and diastolic velocities were decreased significantly in the central retinal artery (P < 0.02 and P < 0.01, respectively), temporal posterior ciliary artery (P < 0.05 and P < 0.03, respectively), and nasal posterior ciliary artery (P < 0.03 and P < 0.02, respectively). Pourcelot's ratio was significantly increased in the central retinal artery (P < 0.01), temporal posterior ciliary artery (P < 0.02), and nasal posterior ciliary artery (P < 0.02) after retrobulbar injection of lidocaine with epinephrine.

CONCLUSIONS

These results indicate that one drop of topical epinephrine has little or no effect on the retrobulbar circulation, whereas retrobulbar injection of anesthetic solution containing lidocaine with epinephrine significantly alters retrobulbar hemodynamics in the monkey eye.

Authors+Show Affiliations

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9375585

Citation

Netland, P A., et al. "Color Doppler Ultrasound Measurements After Topical and Retrobulbar Epinephrine in Primate Eyes." Investigative Ophthalmology & Visual Science, vol. 38, no. 12, 1997, pp. 2655-61.
Netland PA, Siegner SW, Harris A. Color Doppler ultrasound measurements after topical and retrobulbar epinephrine in primate eyes. Invest Ophthalmol Vis Sci. 1997;38(12):2655-61.
Netland, P. A., Siegner, S. W., & Harris, A. (1997). Color Doppler ultrasound measurements after topical and retrobulbar epinephrine in primate eyes. Investigative Ophthalmology & Visual Science, 38(12), 2655-61.
Netland PA, Siegner SW, Harris A. Color Doppler Ultrasound Measurements After Topical and Retrobulbar Epinephrine in Primate Eyes. Invest Ophthalmol Vis Sci. 1997;38(12):2655-61. PubMed PMID: 9375585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Color Doppler ultrasound measurements after topical and retrobulbar epinephrine in primate eyes. AU - Netland,P A, AU - Siegner,S W, AU - Harris,A, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez SP - 2655 EP - 61 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 38 IS - 12 N2 - PURPOSE: To determine the effects of topical epinephrine and retrobulbar anesthesia containing lidocaine with epinephrine on retrobulbar hemodynamic measurements in the primate eye, using color Doppler ultrasound. METHODS: Color Doppler ultrasound measurements were performed at baseline and 90 minutes after masked administration of topical 2% epinephrine or balanced salt solution to six cynomolgus monkeys. Measurements were also performed at baseline and 30 minutes after retrobulbar injection of 2% lidocaine, with or without 1:200,000 epinephrine. RESULTS: After topical epinephrine, color Doppler ultrasound measurements were not significantly different compared with baseline measurements in the central retinal artery, posterior ciliary arteries, and superior ophthalmic vein. There were decreased systolic and diastolic velocities in the ophthalmic artery (P < 0.03 and P < 0.02, respectively) after topical epinephrine; however, Pourcelot's ratio (resistive index) was not significantly different compared with that at baseline. In contrast, there were marked changes in the retrobulbar arterial circulation after retrobulbar injection of lidocaine with epinephrine. The systolic and diastolic velocities were decreased significantly in the central retinal artery (P < 0.02 and P < 0.01, respectively), temporal posterior ciliary artery (P < 0.05 and P < 0.03, respectively), and nasal posterior ciliary artery (P < 0.03 and P < 0.02, respectively). Pourcelot's ratio was significantly increased in the central retinal artery (P < 0.01), temporal posterior ciliary artery (P < 0.02), and nasal posterior ciliary artery (P < 0.02) after retrobulbar injection of lidocaine with epinephrine. CONCLUSIONS: These results indicate that one drop of topical epinephrine has little or no effect on the retrobulbar circulation, whereas retrobulbar injection of anesthetic solution containing lidocaine with epinephrine significantly alters retrobulbar hemodynamics in the monkey eye. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/9375585/Color_Doppler_ultrasound_measurements_after_topical_and_retrobulbar_epinephrine_in_primate_eyes_ L2 - https://iovs.arvojournals.org/article.aspx?volume=38&amp;issue=12&amp;page=2655 DB - PRIME DP - Unbound Medicine ER -