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The analysis of cations and anions in illicit heroin using capillary electrophoresis with indirect UV detection.
J Capillary Electrophor. 1996 Sep-Oct; 3(5):237-42.JC

Abstract

Methodology is presented for the analysis of cations and anions in illicit heroin using CE with indirect UV detection. The cations investigated include ammonium, calcium, potassium, magnesium, and sodium; the anions included acetate, chloride, citrate, phosphate, sulfate, and tartrate. For cations, the Ion Phor run buffer (Dionex Corp., Sunnyvale, CA, U.S.A.) consisting of 4 mM copper sulfate, 4 mM formic acid, and 3 mM 18-crown-6 (pH 3.0) was used. For anions, proprietary reagents were used, including the Anitron run buffer (PE Applied Biosystems, Foster City, CA, U.S.A.) and Micro-Coat capillary charge-reversal agent (PE Applied Biosystems), which was utilized to flush the capillary prior to each analysis. Lithium nitrate was used as an internal standard; excellent long- and short-term precision in relative retention times were obtained for both cations and anions. The short-term precision in peak areas was satisfactory. For the various ions examined, a linearity range of a little less than two orders of magnitude was observed. The methodology is capable of analyzing ions down to the 10(-3)% level relative to heroin.

Authors+Show Affiliations

Lurie IS
U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, VA 22102-3494, USA.

MeSH

AnionsCationsElectrophoresis, CapillaryHeroinIllicit DrugsIndicators and ReagentsReproducibility of ResultsSensitivity and SpecificitySpectrophotometry, Ultraviolet

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9384728

Citation

Lurie, I S.. "The Analysis of Cations and Anions in Illicit Heroin Using Capillary Electrophoresis With Indirect UV Detection." Journal of Capillary Electrophoresis, vol. 3, no. 5, 1996, pp. 237-42.
Lurie IS. The analysis of cations and anions in illicit heroin using capillary electrophoresis with indirect UV detection. J Capillary Electrophor. 1996;3(5):237-42.
Lurie, I. S. (1996). The analysis of cations and anions in illicit heroin using capillary electrophoresis with indirect UV detection. Journal of Capillary Electrophoresis, 3(5), 237-42.
Lurie IS. The Analysis of Cations and Anions in Illicit Heroin Using Capillary Electrophoresis With Indirect UV Detection. J Capillary Electrophor. 1996 Sep-Oct;3(5):237-42. PubMed PMID: 9384728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The analysis of cations and anions in illicit heroin using capillary electrophoresis with indirect UV detection. A1 - Lurie,I S, PY - 1996/9/1/pubmed PY - 1997/12/31/medline PY - 1996/9/1/entrez SP - 237 EP - 42 JF - Journal of capillary electrophoresis JO - J Capillary Electrophor VL - 3 IS - 5 N2 - Methodology is presented for the analysis of cations and anions in illicit heroin using CE with indirect UV detection. The cations investigated include ammonium, calcium, potassium, magnesium, and sodium; the anions included acetate, chloride, citrate, phosphate, sulfate, and tartrate. For cations, the Ion Phor run buffer (Dionex Corp., Sunnyvale, CA, U.S.A.) consisting of 4 mM copper sulfate, 4 mM formic acid, and 3 mM 18-crown-6 (pH 3.0) was used. For anions, proprietary reagents were used, including the Anitron run buffer (PE Applied Biosystems, Foster City, CA, U.S.A.) and Micro-Coat capillary charge-reversal agent (PE Applied Biosystems), which was utilized to flush the capillary prior to each analysis. Lithium nitrate was used as an internal standard; excellent long- and short-term precision in relative retention times were obtained for both cations and anions. The short-term precision in peak areas was satisfactory. For the various ions examined, a linearity range of a little less than two orders of magnitude was observed. The methodology is capable of analyzing ions down to the 10(-3)% level relative to heroin. SN - 1079-5383 UR - https://www.unboundmedicine.com/medline/citation/9384728/The_analysis_of_cations_and_anions_in_illicit_heroin_using_capillary_electrophoresis_with_indirect_UV_detection_ DB - PRIME DP - Unbound Medicine ER -