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Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region.
Hum Genet. 1997 Nov; 101(1):102-8.HG

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480-D11S913) high-density clone contig-based, physical map generated for the MEN1 region.

Authors+Show Affiliations

Laboratory of Gene Transfer, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4442, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9385379

Citation

Manickam, P, et al. "Eighteen New Polymorphic Markers in the Multiple Endocrine Neoplasia Type 1 (MEN1) Region." Human Genetics, vol. 101, no. 1, 1997, pp. 102-8.
Manickam P, Guru SC, Debelenko LV, et al. Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Hum Genet. 1997;101(1):102-8.
Manickam, P., Guru, S. C., Debelenko, L. V., Agarwal, S. K., Olufemi, S. E., Weisemann, J. M., Boguski, M. S., Crabtree, J. S., Wang, Y., Roe, B. A., Lubensky, I. A., Zhuang, Z., Kester, M. B., Burns, A. L., Spiegel, A. M., Marx, S. J., Liotta, L. A., Emmert-Buck, M. R., Collins, F. S., & Chandrasekharappa, S. C. (1997). Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Human Genetics, 101(1), 102-8.
Manickam P, et al. Eighteen New Polymorphic Markers in the Multiple Endocrine Neoplasia Type 1 (MEN1) Region. Hum Genet. 1997;101(1):102-8. PubMed PMID: 9385379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. AU - Manickam,P, AU - Guru,S C, AU - Debelenko,L V, AU - Agarwal,S K, AU - Olufemi,S E, AU - Weisemann,J M, AU - Boguski,M S, AU - Crabtree,J S, AU - Wang,Y, AU - Roe,B A, AU - Lubensky,I A, AU - Zhuang,Z, AU - Kester,M B, AU - Burns,A L, AU - Spiegel,A M, AU - Marx,S J, AU - Liotta,L A, AU - Emmert-Buck,M R, AU - Collins,F S, AU - Chandrasekharappa,S C, PY - 1998/1/7/pubmed PY - 1998/1/7/medline PY - 1998/1/7/entrez SP - 102 EP - 8 JF - Human genetics JO - Hum Genet VL - 101 IS - 1 N2 - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480-D11S913) high-density clone contig-based, physical map generated for the MEN1 region. SN - 0340-6717 UR - https://www.unboundmedicine.com/medline/citation/9385379/Eighteen_new_polymorphic_markers_in_the_multiple_endocrine_neoplasia_type_1__MEN1__region_ L2 - https://dx.doi.org/10.1007/s004390050595 DB - PRIME DP - Unbound Medicine ER -