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Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly.
Neurobiol Aging. 1997 Sep-Oct; 18(5):491-5.NA

Abstract

In aging, a decline in sleep continuity, a decreased slow wave sleep, an earlier nocturnal cortisol rise, and a blunted growth hormone (GH) secretion occur. Pulsatile administration of GH-releasing hormone (GHRH) in young controls enhanced slow wave sleep and suppressed cortisol release. We administered GHRH 4 x 50 microg or placebo i.v. to 13 healthy seniors (5 women, 8 men, mean age 69.3 y +/- 8.3 SD). We observed significantly reduced nocturnal awakenings and an increased first non-rapid-eye-movement sleep period. In a subgroup (n = 9), we found a significant activation of GH secretion but unchanged cortisol secretion. Our data underscore that GHRH is capable of promoting sleep in the elderly, but much less than in young subjects. Contrasting to young subjects, the hypothalamic-pituitary-adrenocortical system remains unaffected by GHRH in the elderly. These results provide further evidence that a decrease in the efficacy of GHRH is involved in the biological mechanisms underlying aging.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9390775

Citation

Guldner, J, et al. "Reduced Efficacy of Growth Hormone-releasing Hormone in Modulating Sleep Endocrine Activity in the Elderly." Neurobiology of Aging, vol. 18, no. 5, 1997, pp. 491-5.
Guldner J, Schier T, Friess E, et al. Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiol Aging. 1997;18(5):491-5.
Guldner, J., Schier, T., Friess, E., Colla, M., Holsboer, F., & Steiger, A. (1997). Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiology of Aging, 18(5), 491-5.
Guldner J, et al. Reduced Efficacy of Growth Hormone-releasing Hormone in Modulating Sleep Endocrine Activity in the Elderly. Neurobiol Aging. 1997 Sep-Oct;18(5):491-5. PubMed PMID: 9390775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. AU - Guldner,J, AU - Schier,T, AU - Friess,E, AU - Colla,M, AU - Holsboer,F, AU - Steiger,A, PY - 1997/12/9/pubmed PY - 1997/12/9/medline PY - 1997/12/9/entrez SP - 491 EP - 5 JF - Neurobiology of aging JO - Neurobiol Aging VL - 18 IS - 5 N2 - In aging, a decline in sleep continuity, a decreased slow wave sleep, an earlier nocturnal cortisol rise, and a blunted growth hormone (GH) secretion occur. Pulsatile administration of GH-releasing hormone (GHRH) in young controls enhanced slow wave sleep and suppressed cortisol release. We administered GHRH 4 x 50 microg or placebo i.v. to 13 healthy seniors (5 women, 8 men, mean age 69.3 y +/- 8.3 SD). We observed significantly reduced nocturnal awakenings and an increased first non-rapid-eye-movement sleep period. In a subgroup (n = 9), we found a significant activation of GH secretion but unchanged cortisol secretion. Our data underscore that GHRH is capable of promoting sleep in the elderly, but much less than in young subjects. Contrasting to young subjects, the hypothalamic-pituitary-adrenocortical system remains unaffected by GHRH in the elderly. These results provide further evidence that a decrease in the efficacy of GHRH is involved in the biological mechanisms underlying aging. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/9390775/Reduced_efficacy_of_growth_hormone_releasing_hormone_in_modulating_sleep_endocrine_activity_in_the_elderly_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(97)00106-1 DB - PRIME DP - Unbound Medicine ER -