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Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias.
Ann Neurol. 1997 Nov; 42(5):720-6.AN

Abstract

Levodopa-induced dyskinesias remain a major challenge in the therapeutic management of Parkinson's disease (PD). Their etiology is unknown although dysfunction of striatal opioid transmission has been implicated in experimental models of PD. To determine whether the opioid system is involved in human dyskinetic PD, we measured in vivo opioid receptor binding in PD patients with and without levodopa-induced dyskinesias, using positron emission tomography (PET) and the opioid receptor ligand [11C]diprenorphine. Striatal and thalamic/occipital uptake ratios were calculated using a region of interest (ROI) approach. In addition, we used statistical parametric mapping (SPM) and images reflecting the volume of distribution of [11C]diprenorphine to assess changes in cerebral receptor binding on a voxel-by-voxel basis. By using the ROI approach, we found significantly reduced striatal and thalamic opioid binding in dyskinetic, but not in nondyskinetic, PD patients. The SPM approach confirmed reduced availability in these areas and, in addition, showed decreased cingulate and increased prefrontal opioid receptor binding in the dyskinetic patients. Our findings confirm that altered opioid transmission is part of the pathophysiology of levodopa-induced dyskinesias in PD and support further investigation into the role of opioid agents in the management of these involuntary movements.

Authors+Show Affiliations

MRC Cyclotron Unit, Hammersmith Hospital, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9392571

Citation

Piccini, P, et al. "Alterations in Opioid Receptor Binding in Parkinson's Disease Patients With Levodopa-induced Dyskinesias." Annals of Neurology, vol. 42, no. 5, 1997, pp. 720-6.
Piccini P, Weeks RA, Brooks DJ. Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias. Ann Neurol. 1997;42(5):720-6.
Piccini, P., Weeks, R. A., & Brooks, D. J. (1997). Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias. Annals of Neurology, 42(5), 720-6.
Piccini P, Weeks RA, Brooks DJ. Alterations in Opioid Receptor Binding in Parkinson's Disease Patients With Levodopa-induced Dyskinesias. Ann Neurol. 1997;42(5):720-6. PubMed PMID: 9392571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias. AU - Piccini,P, AU - Weeks,R A, AU - Brooks,D J, PY - 1997/12/10/pubmed PY - 1997/12/10/medline PY - 1997/12/10/entrez SP - 720 EP - 6 JF - Annals of neurology JO - Ann Neurol VL - 42 IS - 5 N2 - Levodopa-induced dyskinesias remain a major challenge in the therapeutic management of Parkinson's disease (PD). Their etiology is unknown although dysfunction of striatal opioid transmission has been implicated in experimental models of PD. To determine whether the opioid system is involved in human dyskinetic PD, we measured in vivo opioid receptor binding in PD patients with and without levodopa-induced dyskinesias, using positron emission tomography (PET) and the opioid receptor ligand [11C]diprenorphine. Striatal and thalamic/occipital uptake ratios were calculated using a region of interest (ROI) approach. In addition, we used statistical parametric mapping (SPM) and images reflecting the volume of distribution of [11C]diprenorphine to assess changes in cerebral receptor binding on a voxel-by-voxel basis. By using the ROI approach, we found significantly reduced striatal and thalamic opioid binding in dyskinetic, but not in nondyskinetic, PD patients. The SPM approach confirmed reduced availability in these areas and, in addition, showed decreased cingulate and increased prefrontal opioid receptor binding in the dyskinetic patients. Our findings confirm that altered opioid transmission is part of the pathophysiology of levodopa-induced dyskinesias in PD and support further investigation into the role of opioid agents in the management of these involuntary movements. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/9392571/Alterations_in_opioid_receptor_binding_in_Parkinson's_disease_patients_with_levodopa_induced_dyskinesias_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1997&volume=42&issue=5&spage=720 DB - PRIME DP - Unbound Medicine ER -