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Gastric myoelectrical activity, gastric emptying and correlations with dyspepsia symptoms in patients with gastroesophageal reflux.
J Investig Med 1997; 45(8):483-7JI

Abstract

BACKGROUND

Delayed gastric emptying is a mechanism that contributes to the pathogenesis of gastroesophageal reflux. Electrogastrogram changes, gastric emptying rates, and Helicobacter pylori status were investigated, and a correlation was sought with dyspepsia symptoms in gastroesophageal reflux disease patients.

METHODS

Fifty patients (27 females; mean age 43) with gastroesophageal reflux were studied. Electrogastrographic recordings were obtained 30 minutes before and simultaneously with a 2-hour radionuclide gastric-emptying test using an isotope-labeled solid meal. Symptoms of nausea, abdominal bloating, abdominal pain, and early satiety were graded from 0 to 5.

RESULTS

Thirty-six percent of patients had delayed gastric eliminating. Thirty-eight percent (19/50) patients had abnormal electrogastrograms, and 11 of these 19 also had delayed gastric emptying. There was a significant difference in the electrogastrographic parameter of postprandial power change in patients with delayed versus normal gastric emptying (0.20 +/- 0.8 dB vs 3.17 +/- 0.8 dB, p < 0.05). In patients with an abnormal electrogastrogram, the mean symptom score was significantly higher than in patients with a normal electrogastrogram (2.18 +/- 0.26 vs 1.35 +/- 0.16, p < 0.05). Twenty-one percent (7/33) of patients were positive (+) for Helicobacter pylori overall, but this did not seem to affect electrogastrogram and gastric emptying findings.

CONCLUSIONS

Fifty-two percent of gastroesophageal reflux disease patients have gastric motor or myoelectrical abnormalities that contribute to the pathogenesis of this entity and also help explain the high prevalence of dyspepsia in the clinical presentation of gastroesophageal reflux disease.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, University of Ankara Medical School, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9394102

Citation

Soykan, I, et al. "Gastric Myoelectrical Activity, Gastric Emptying and Correlations With Dyspepsia Symptoms in Patients With Gastroesophageal Reflux." Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, vol. 45, no. 8, 1997, pp. 483-7.
Soykan I, Lin Z, Jones S, et al. Gastric myoelectrical activity, gastric emptying and correlations with dyspepsia symptoms in patients with gastroesophageal reflux. J Investig Med. 1997;45(8):483-7.
Soykan, I., Lin, Z., Jones, S., Chen, J., & McCallum, R. W. (1997). Gastric myoelectrical activity, gastric emptying and correlations with dyspepsia symptoms in patients with gastroesophageal reflux. Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, 45(8), pp. 483-7.
Soykan I, et al. Gastric Myoelectrical Activity, Gastric Emptying and Correlations With Dyspepsia Symptoms in Patients With Gastroesophageal Reflux. J Investig Med. 1997;45(8):483-7. PubMed PMID: 9394102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric myoelectrical activity, gastric emptying and correlations with dyspepsia symptoms in patients with gastroesophageal reflux. AU - Soykan,I, AU - Lin,Z, AU - Jones,S, AU - Chen,J, AU - McCallum,R W, PY - 1997/12/12/pubmed PY - 1997/12/12/medline PY - 1997/12/12/entrez SP - 483 EP - 7 JF - Journal of investigative medicine : the official publication of the American Federation for Clinical Research JO - J. Investig. Med. VL - 45 IS - 8 N2 - BACKGROUND: Delayed gastric emptying is a mechanism that contributes to the pathogenesis of gastroesophageal reflux. Electrogastrogram changes, gastric emptying rates, and Helicobacter pylori status were investigated, and a correlation was sought with dyspepsia symptoms in gastroesophageal reflux disease patients. METHODS: Fifty patients (27 females; mean age 43) with gastroesophageal reflux were studied. Electrogastrographic recordings were obtained 30 minutes before and simultaneously with a 2-hour radionuclide gastric-emptying test using an isotope-labeled solid meal. Symptoms of nausea, abdominal bloating, abdominal pain, and early satiety were graded from 0 to 5. RESULTS: Thirty-six percent of patients had delayed gastric eliminating. Thirty-eight percent (19/50) patients had abnormal electrogastrograms, and 11 of these 19 also had delayed gastric emptying. There was a significant difference in the electrogastrographic parameter of postprandial power change in patients with delayed versus normal gastric emptying (0.20 +/- 0.8 dB vs 3.17 +/- 0.8 dB, p < 0.05). In patients with an abnormal electrogastrogram, the mean symptom score was significantly higher than in patients with a normal electrogastrogram (2.18 +/- 0.26 vs 1.35 +/- 0.16, p < 0.05). Twenty-one percent (7/33) of patients were positive (+) for Helicobacter pylori overall, but this did not seem to affect electrogastrogram and gastric emptying findings. CONCLUSIONS: Fifty-two percent of gastroesophageal reflux disease patients have gastric motor or myoelectrical abnormalities that contribute to the pathogenesis of this entity and also help explain the high prevalence of dyspepsia in the clinical presentation of gastroesophageal reflux disease. SN - 1081-5589 UR - https://www.unboundmedicine.com/medline/citation/9394102/Gastric_myoelectrical_activity_gastric_emptying_and_correlations_with_dyspepsia_symptoms_in_patients_with_gastroesophageal_reflux_ L2 - http://jim.bmj.com/cgi/pmidlookup?view=long&amp;pmid=9394102 DB - PRIME DP - Unbound Medicine ER -