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Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review.
Alcohol Clin Exp Res 1997; 21(8):1360-6AC

Abstract

The stomach provides some protection against the penetration of ethanol into the body by contributing to the metabolism of ethanol. The latter is attenuated by various drugs and, although the magnitude of this effect is still the subject of debate, patients should be warned of the corresponding possible increase in blood alcohol levels. Furthermore, oxidation of ethanol generates acetaldehyde, a toxic metabolite. In addition, chronic alcohol abuse seems to favor colonization by Helicobacter pylori, which produces ammonia that also contributes to the commonly associated chronic gastritis. Because antibiotics were shown over the last 4 decades to effectively eliminate gastric ammonia, they should be considered for the routine treatment of such chronic gastritis in the way they are now being used for ulcer therapy.

Authors+Show Affiliations

Department of Medicine and Pathology, Mount Sinai School of Medicine, Bronx, New York, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9394105

Citation

Lieber, C S.. "Gastric Ethanol Metabolism and Gastritis: Interactions With Other Drugs, Helicobacter Pylori, and Antibiotic Therapy (1957-1997)--a Review." Alcoholism, Clinical and Experimental Research, vol. 21, no. 8, 1997, pp. 1360-6.
Lieber CS. Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review. Alcohol Clin Exp Res. 1997;21(8):1360-6.
Lieber, C. S. (1997). Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review. Alcoholism, Clinical and Experimental Research, 21(8), pp. 1360-6.
Lieber CS. Gastric Ethanol Metabolism and Gastritis: Interactions With Other Drugs, Helicobacter Pylori, and Antibiotic Therapy (1957-1997)--a Review. Alcohol Clin Exp Res. 1997;21(8):1360-6. PubMed PMID: 9394105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review. A1 - Lieber,C S, PY - 1997/12/12/pubmed PY - 1997/12/12/medline PY - 1997/12/12/entrez SP - 1360 EP - 6 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 21 IS - 8 N2 - The stomach provides some protection against the penetration of ethanol into the body by contributing to the metabolism of ethanol. The latter is attenuated by various drugs and, although the magnitude of this effect is still the subject of debate, patients should be warned of the corresponding possible increase in blood alcohol levels. Furthermore, oxidation of ethanol generates acetaldehyde, a toxic metabolite. In addition, chronic alcohol abuse seems to favor colonization by Helicobacter pylori, which produces ammonia that also contributes to the commonly associated chronic gastritis. Because antibiotics were shown over the last 4 decades to effectively eliminate gastric ammonia, they should be considered for the routine treatment of such chronic gastritis in the way they are now being used for ulcer therapy. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/9394105/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1997&volume=21&issue=8&spage=1360 DB - PRIME DP - Unbound Medicine ER -