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Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review.

Abstract

The stomach provides some protection against the penetration of ethanol into the body by contributing to the metabolism of ethanol. The latter is attenuated by various drugs and, although the magnitude of this effect is still the subject of debate, patients should be warned of the corresponding possible increase in blood alcohol levels. Furthermore, oxidation of ethanol generates acetaldehyde, a toxic metabolite. In addition, chronic alcohol abuse seems to favor colonization by Helicobacter pylori, which produces ammonia that also contributes to the commonly associated chronic gastritis. Because antibiotics were shown over the last 4 decades to effectively eliminate gastric ammonia, they should be considered for the routine treatment of such chronic gastritis in the way they are now being used for ulcer therapy.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Medicine and Pathology, Mount Sinai School of Medicine, Bronx, New York, USA.

    Source

    MeSH

    Alcohol Dehydrogenase
    Alcohol Drinking
    Animals
    Anti-Ulcer Agents
    Drug Synergism
    Ethanol
    Gastric Mucosa
    Gastritis
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Metabolic Clearance Rate

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    9394105

    Citation

    Lieber, C S.. "Gastric Ethanol Metabolism and Gastritis: Interactions With Other Drugs, Helicobacter Pylori, and Antibiotic Therapy (1957-1997)--a Review." Alcoholism, Clinical and Experimental Research, vol. 21, no. 8, 1997, pp. 1360-6.
    Lieber CS. Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review. Alcohol Clin Exp Res. 1997;21(8):1360-6.
    Lieber, C. S. (1997). Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review. Alcoholism, Clinical and Experimental Research, 21(8), pp. 1360-6.
    Lieber CS. Gastric Ethanol Metabolism and Gastritis: Interactions With Other Drugs, Helicobacter Pylori, and Antibiotic Therapy (1957-1997)--a Review. Alcohol Clin Exp Res. 1997;21(8):1360-6. PubMed PMID: 9394105.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review. A1 - Lieber,C S, PY - 1997/12/12/pubmed PY - 1997/12/12/medline PY - 1997/12/12/entrez SP - 1360 EP - 6 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 21 IS - 8 N2 - The stomach provides some protection against the penetration of ethanol into the body by contributing to the metabolism of ethanol. The latter is attenuated by various drugs and, although the magnitude of this effect is still the subject of debate, patients should be warned of the corresponding possible increase in blood alcohol levels. Furthermore, oxidation of ethanol generates acetaldehyde, a toxic metabolite. In addition, chronic alcohol abuse seems to favor colonization by Helicobacter pylori, which produces ammonia that also contributes to the commonly associated chronic gastritis. Because antibiotics were shown over the last 4 decades to effectively eliminate gastric ammonia, they should be considered for the routine treatment of such chronic gastritis in the way they are now being used for ulcer therapy. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/9394105/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1997&volume=21&issue=8&spage=1360 DB - PRIME DP - Unbound Medicine ER -