Tags

Type your tag names separated by a space and hit enter

Naltrexone in young autistic children: replication study and learning measures.
J Am Acad Child Adolesc Psychiatry. 1997 Nov; 36(11):1570-8.JA

Abstract

OBJECTIVE

This study expanded upon previous work on naltrexone efficacy and safety in young autistic children and assessed performance on learning measures.

METHOD

Eleven children with autistic disorder, aged 3.0 to 8.3 years, were studied in home, school, and outpatient laboratory, bringing to 24 the combined study sample. Naltrexone, 1.0 mg/kg, was given daily in a randomized, double-blind, crossover design. Dependent measures were parent and teacher Clinical Global Impressions (CGI) and Naltrexone Side Effects Rating Scale (SE), Conners Parent Impulsivity/Hyperactivity Factor, Teacher Hyperactivity Factor, laboratory CGI, and analysis of videotaped behavior. Learning measures were the Early Intervention Developmental Profile-Language and paired-associate learning.

RESULTS

Comparisons between naltrexone and baseline, but not naltrexone and placebo, on parent and teacher ratings showed statistical significance. Three of 11 subjects improved in two or more settings. Side effects were mild. Administering naltrexone was a challenge. The combined study sample showed improvement on all parent measures and on Teacher CGI and SE-Restlessness compared with baseline and placebo. Eleven of the 24 children improved in two or more settings. Scores on learning measures did not change across conditions.

CONCLUSIONS

Naltrexone was associated with modest improvement of behavior in 11 of 24 children, but learning did not improve.

Authors+Show Affiliations

Children's Hospital of Pittsburgh, PA, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9394942

Citation

Kolmen, B K., et al. "Naltrexone in Young Autistic Children: Replication Study and Learning Measures." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 36, no. 11, 1997, pp. 1570-8.
Kolmen BK, Feldman HM, Handen BL, et al. Naltrexone in young autistic children: replication study and learning measures. J Am Acad Child Adolesc Psychiatry. 1997;36(11):1570-8.
Kolmen, B. K., Feldman, H. M., Handen, B. L., & Janosky, J. E. (1997). Naltrexone in young autistic children: replication study and learning measures. Journal of the American Academy of Child and Adolescent Psychiatry, 36(11), 1570-8.
Kolmen BK, et al. Naltrexone in Young Autistic Children: Replication Study and Learning Measures. J Am Acad Child Adolesc Psychiatry. 1997;36(11):1570-8. PubMed PMID: 9394942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naltrexone in young autistic children: replication study and learning measures. AU - Kolmen,B K, AU - Feldman,H M, AU - Handen,B L, AU - Janosky,J E, PY - 1997/12/12/pubmed PY - 1997/12/12/medline PY - 1997/12/12/entrez SP - 1570 EP - 8 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 36 IS - 11 N2 - OBJECTIVE: This study expanded upon previous work on naltrexone efficacy and safety in young autistic children and assessed performance on learning measures. METHOD: Eleven children with autistic disorder, aged 3.0 to 8.3 years, were studied in home, school, and outpatient laboratory, bringing to 24 the combined study sample. Naltrexone, 1.0 mg/kg, was given daily in a randomized, double-blind, crossover design. Dependent measures were parent and teacher Clinical Global Impressions (CGI) and Naltrexone Side Effects Rating Scale (SE), Conners Parent Impulsivity/Hyperactivity Factor, Teacher Hyperactivity Factor, laboratory CGI, and analysis of videotaped behavior. Learning measures were the Early Intervention Developmental Profile-Language and paired-associate learning. RESULTS: Comparisons between naltrexone and baseline, but not naltrexone and placebo, on parent and teacher ratings showed statistical significance. Three of 11 subjects improved in two or more settings. Side effects were mild. Administering naltrexone was a challenge. The combined study sample showed improvement on all parent measures and on Teacher CGI and SE-Restlessness compared with baseline and placebo. Eleven of the 24 children improved in two or more settings. Scores on learning measures did not change across conditions. CONCLUSIONS: Naltrexone was associated with modest improvement of behavior in 11 of 24 children, but learning did not improve. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/9394942/Naltrexone_in_young_autistic_children:_replication_study_and_learning_measures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)66567-9 DB - PRIME DP - Unbound Medicine ER -