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Pathophysiology of portal hypertension.
Baillieres Clin Gastroenterol. 1997 Jun; 11(2):203-19.BC

Abstract

Portal hypertension is a common clinical syndrome associated with chronic liver diseases and is characterized by a pathological increase in portal pressure. Increase in portal pressure is because of an increase in vascular resistance and an elevated portal blood flow. The site of increased intrahepatic resistance is variable and is dependent on the disease process. The site of obstruction may be: pre-hepatic, hepatic, and/or post-hepatic. In addition, part of the increased intrahepatic resistance is because of increased vascular tone. Another important factor contributing to increased portal pressure is elevated blood flow. Peripheral vasodilatation initiates the classical profile of decreased systemic resistance, expanded plasma volume, elevated splanchnic blood flow and elevated cardiac index. The elevated portal pressure leads to formation of portosystemic collaterals and oesophageal varices. Pharmacotherapy for portal hypertension is aimed at reducing both intrahepatic vascular tone and elevated splanchnic blood flow.

Authors+Show Affiliations

Hepatic Hemodynamic Laboratory, VA Medical Center, West Haven, CT 06516, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9395744

Citation

Gupta, T K., et al. "Pathophysiology of Portal Hypertension." Bailliere's Clinical Gastroenterology, vol. 11, no. 2, 1997, pp. 203-19.
Gupta TK, Chen L, Groszmann RJ. Pathophysiology of portal hypertension. Baillieres Clin Gastroenterol. 1997;11(2):203-19.
Gupta, T. K., Chen, L., & Groszmann, R. J. (1997). Pathophysiology of portal hypertension. Bailliere's Clinical Gastroenterology, 11(2), 203-19.
Gupta TK, Chen L, Groszmann RJ. Pathophysiology of Portal Hypertension. Baillieres Clin Gastroenterol. 1997;11(2):203-19. PubMed PMID: 9395744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathophysiology of portal hypertension. AU - Gupta,T K, AU - Chen,L, AU - Groszmann,R J, PY - 1997/6/1/pubmed PY - 1997/12/13/medline PY - 1997/6/1/entrez SP - 203 EP - 19 JF - Bailliere's clinical gastroenterology JO - Baillieres Clin Gastroenterol VL - 11 IS - 2 N2 - Portal hypertension is a common clinical syndrome associated with chronic liver diseases and is characterized by a pathological increase in portal pressure. Increase in portal pressure is because of an increase in vascular resistance and an elevated portal blood flow. The site of increased intrahepatic resistance is variable and is dependent on the disease process. The site of obstruction may be: pre-hepatic, hepatic, and/or post-hepatic. In addition, part of the increased intrahepatic resistance is because of increased vascular tone. Another important factor contributing to increased portal pressure is elevated blood flow. Peripheral vasodilatation initiates the classical profile of decreased systemic resistance, expanded plasma volume, elevated splanchnic blood flow and elevated cardiac index. The elevated portal pressure leads to formation of portosystemic collaterals and oesophageal varices. Pharmacotherapy for portal hypertension is aimed at reducing both intrahepatic vascular tone and elevated splanchnic blood flow. SN - 0950-3528 UR - https://www.unboundmedicine.com/medline/citation/9395744/Pathophysiology_of_portal_hypertension_ L2 - http://www.diseaseinfosearch.org/result/5881 DB - PRIME DP - Unbound Medicine ER -