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[Serum levels of soluble tumor necrosis factor receptors as markers for disease progression of human immunodeficiency virus infection].
Rinsho Byori. 1997 Nov; 45(11):1085-90.RB

Abstract

We studied whether the serum levels of soluble tumor necrosis factor receptor(sTNFR) type I or II correlate with clinical progression of human immunodeficiency virus type 1(HIV-1) infection. Serum levels of sTNFR type I and II were measured by an enzyme-linked immunosorbent assay in sixty five patients with HIV-1 infected hemophiliacs and 10 healthy controls. In a longitudinal study, we assessed whether the decline of CD4+ lymphocyte counts were associated with increased serum concentrations of sTNFRs. Elevated serum concentrations of sTNFRs were found among the HIV-1 infected patients and higher in patients with advanced clinical stage. We noticed there were two distinct patient groups in change of CD4+ lymphocyte count when twenty-eight patients were followed retrospectively for a median period of 65 months. 14 patients represented stable CD4+ lymphocyte counts, but another 14 patients had more than 40% decrease of CD4+ lymphocyte counts over the course of this study. Serum sTNFR type II levels were 3.49 +/- 0.71 to 3.11 +/- 0.31 ng/ml in the former group, and 4.88 +/- 0.91 to 4.26 +/- 0.71 ng/ml in the latter group during the study. Significantly higher levels of sTNFR type II were already revealed at early time in the latter group. There was, however, no significant difference in the level of sTNFR type I between the two. These results suggest that serum levels of sTNFR type II provided useful information as a predictor of disease progression related to the decline of CD4+ lymphocyte counts.

Authors+Show Affiliations

Hattori M
Department of Clinical Pathology, Tokyo Medical College.
Tateyama M
No affiliation info available
Oishi T
No affiliation info available
Miyasaka S
No affiliation info available
Fukutake K
No affiliation info available

MeSH

AdultBiomarkersCD4-Positive T-LymphocytesDisease ProgressionHIV InfectionsHIV-1Hemophilia AHumansLymphocyte CountMiddle AgedReceptors, Tumor Necrosis FactorRetrospective StudiesSolubility

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

9396350

Citation

Hattori, M, et al. "[Serum Levels of Soluble Tumor Necrosis Factor Receptors as Markers for Disease Progression of Human Immunodeficiency Virus Infection]." Rinsho Byori. the Japanese Journal of Clinical Pathology, vol. 45, no. 11, 1997, pp. 1085-90.
Hattori M, Tateyama M, Oishi T, et al. [Serum levels of soluble tumor necrosis factor receptors as markers for disease progression of human immunodeficiency virus infection]. Rinsho Byori. 1997;45(11):1085-90.
Hattori, M., Tateyama, M., Oishi, T., Miyasaka, S., & Fukutake, K. (1997). [Serum levels of soluble tumor necrosis factor receptors as markers for disease progression of human immunodeficiency virus infection]. Rinsho Byori. the Japanese Journal of Clinical Pathology, 45(11), 1085-90.
Hattori M, et al. [Serum Levels of Soluble Tumor Necrosis Factor Receptors as Markers for Disease Progression of Human Immunodeficiency Virus Infection]. Rinsho Byori. 1997;45(11):1085-90. PubMed PMID: 9396350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum levels of soluble tumor necrosis factor receptors as markers for disease progression of human immunodeficiency virus infection]. AU - Hattori,M, AU - Tateyama,M, AU - Oishi,T, AU - Miyasaka,S, AU - Fukutake,K, PY - 1997/12/13/pubmed PY - 1997/12/13/medline PY - 1997/12/13/entrez SP - 1085 EP - 90 JF - Rinsho byori. The Japanese journal of clinical pathology JO - Rinsho Byori VL - 45 IS - 11 N2 - We studied whether the serum levels of soluble tumor necrosis factor receptor(sTNFR) type I or II correlate with clinical progression of human immunodeficiency virus type 1(HIV-1) infection. Serum levels of sTNFR type I and II were measured by an enzyme-linked immunosorbent assay in sixty five patients with HIV-1 infected hemophiliacs and 10 healthy controls. In a longitudinal study, we assessed whether the decline of CD4+ lymphocyte counts were associated with increased serum concentrations of sTNFRs. Elevated serum concentrations of sTNFRs were found among the HIV-1 infected patients and higher in patients with advanced clinical stage. We noticed there were two distinct patient groups in change of CD4+ lymphocyte count when twenty-eight patients were followed retrospectively for a median period of 65 months. 14 patients represented stable CD4+ lymphocyte counts, but another 14 patients had more than 40% decrease of CD4+ lymphocyte counts over the course of this study. Serum sTNFR type II levels were 3.49 +/- 0.71 to 3.11 +/- 0.31 ng/ml in the former group, and 4.88 +/- 0.91 to 4.26 +/- 0.71 ng/ml in the latter group during the study. Significantly higher levels of sTNFR type II were already revealed at early time in the latter group. There was, however, no significant difference in the level of sTNFR type I between the two. These results suggest that serum levels of sTNFR type II provided useful information as a predictor of disease progression related to the decline of CD4+ lymphocyte counts. SN - 0047-1860 UR - https://www.unboundmedicine.com/medline/citation/9396350/[Serum_levels_of_soluble_tumor_necrosis_factor_receptors_as_markers_for_disease_progression_of_human_immunodeficiency_virus_infection]_ L2 - https://medlineplus.gov/hivaids.html DB - PRIME DP - Unbound Medicine ER -