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Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite.
Ann Allergy Asthma Immunol. 1997 Nov; 79(5):427-30.AA

Abstract

BACKGROUND

The allergen skin test is commonly used to ensure the diagnosis of allergic rhinitis even though positive results do not necessarily indicate that rhinitis is of allergic origin.

OBJECTIVE

To determine the association between skin prick reactions and nasal provocation responses to Dermatophagoides pteronyssinus (Der p) allergen extract.

METHODS

Twenty-six patients with perennial rhinitis and 25 controls underwent skin prick and nasal provocation tests to standardized Der p allergen extract. With the use of allergen extract titration delivered by a metered dose pump, nasal stuffiness, itching, and sneezing were noted, the amount of secretions measured, and nasal airway resistance was recorded by active anterior rhinomanometry.

RESULTS

The majority of the patients with rhinitis (20/26), but none of the controls, exhibited strong skin test positivity (4+) to Der p allergen extract. In addition, the majority of the patients with 4+ skin reactions (16/20) had moderate to severe rhinitis. Significantly increased nasal reactivity to the allergen was also observed among those with 4+ skin test positivity. The controls exhibited nasal provocation responses only with significantly higher end-point doses of the allergen extract regardless of the skin test results.

CONCLUSION

Only 4+ skin test positivity was closely associated with increased nasal reactivity to Der p allergen among the patients with perennial rhinitis. The nasal provocation technique would be a useful adjunct testing to ensure the diagnosis of nasal allergy to the Der p mite, particularly among those patients with rhinitis with only mild to moderate skin test positivity.

Authors+Show Affiliations

Department of Pharmacology, Chiang Mai University, Faculty of Medicine, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9396976

Citation

Kanthawatana, S, et al. "Skin Prick Reaction and Nasal Provocation Response in Diagnosis of Nasal Allergy to the House Dust Mite." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 79, no. 5, 1997, pp. 427-30.
Kanthawatana S, Maturim W, Fooanan S, et al. Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite. Ann Allergy Asthma Immunol. 1997;79(5):427-30.
Kanthawatana, S., Maturim, W., Fooanan, S., & Trakultivakorn, M. (1997). Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 79(5), 427-30.
Kanthawatana S, et al. Skin Prick Reaction and Nasal Provocation Response in Diagnosis of Nasal Allergy to the House Dust Mite. Ann Allergy Asthma Immunol. 1997;79(5):427-30. PubMed PMID: 9396976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite. AU - Kanthawatana,S, AU - Maturim,W, AU - Fooanan,S, AU - Trakultivakorn,M, PY - 1997/12/16/pubmed PY - 1997/12/16/medline PY - 1997/12/16/entrez SP - 427 EP - 30 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 79 IS - 5 N2 - BACKGROUND: The allergen skin test is commonly used to ensure the diagnosis of allergic rhinitis even though positive results do not necessarily indicate that rhinitis is of allergic origin. OBJECTIVE: To determine the association between skin prick reactions and nasal provocation responses to Dermatophagoides pteronyssinus (Der p) allergen extract. METHODS: Twenty-six patients with perennial rhinitis and 25 controls underwent skin prick and nasal provocation tests to standardized Der p allergen extract. With the use of allergen extract titration delivered by a metered dose pump, nasal stuffiness, itching, and sneezing were noted, the amount of secretions measured, and nasal airway resistance was recorded by active anterior rhinomanometry. RESULTS: The majority of the patients with rhinitis (20/26), but none of the controls, exhibited strong skin test positivity (4+) to Der p allergen extract. In addition, the majority of the patients with 4+ skin reactions (16/20) had moderate to severe rhinitis. Significantly increased nasal reactivity to the allergen was also observed among those with 4+ skin test positivity. The controls exhibited nasal provocation responses only with significantly higher end-point doses of the allergen extract regardless of the skin test results. CONCLUSION: Only 4+ skin test positivity was closely associated with increased nasal reactivity to Der p allergen among the patients with perennial rhinitis. The nasal provocation technique would be a useful adjunct testing to ensure the diagnosis of nasal allergy to the Der p mite, particularly among those patients with rhinitis with only mild to moderate skin test positivity. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/9396976/Skin_prick_reaction_and_nasal_provocation_response_in_diagnosis_of_nasal_allergy_to_the_house_dust_mite_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)63038-4 DB - PRIME DP - Unbound Medicine ER -