Tags

Type your tag names separated by a space and hit enter

Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone.
Neuropsychopharmacology 1997; 17(6):382-90N

Abstract

Hypothermic and hormonal responses to a challenge with a selective 5-HT1A receptor agonist ipsapirone are considered to provide an index of 5-HT1A receptor function in humans. To examine the effects of divalproex sodium (DVP) on 5-HT1A receptor function in humans, we measured the hypothermic, adrenocorticotropic hormone (ACTH) cortisol, and behavioral responses to ipsapirone in 10 healthy male volunteers. After obtaining a blood sample for baseline hormone levels and measuring body temperature, a single dose of 0.3 mg/kg of ipsapirone was given orally to all the subjects and further bloods and temperature reading were obtained at regular intervals for three hours. The ipsapirone challenge tests were repeated after the subjects had been treated with DVP (1000 mg/day) for one week. The results showed that the hypothermia induced by ipsapirone was significantly attenuated by the DVP treatment, whereas the ACTH/cortisol release and the behavioral responses following ipsapirone challenges were not altered. Our findings suggest that DVP may enhance 5-HT neurotransmission in humans via a subsensitization of 5-HT1A autoreceptors but does not appear to affect postsynaptic 5-HT1A receptors.

Authors+Show Affiliations

Department of Psychiatry, University of British Columbia, Vancouver, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9397426

Citation

Shiah, I S., et al. "Effects of Divalproex Sodium On 5-HT1A Receptor Function in Healthy Human Males: Hypothermic, Hormonal, and Behavioral Responses to Ipsapirone." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 17, no. 6, 1997, pp. 382-90.
Shiah IS, Yatham LN, Lam RW, et al. Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone. Neuropsychopharmacology. 1997;17(6):382-90.
Shiah, I. S., Yatham, L. N., Lam, R. W., & Zis, A. P. (1997). Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 17(6), pp. 382-90.
Shiah IS, et al. Effects of Divalproex Sodium On 5-HT1A Receptor Function in Healthy Human Males: Hypothermic, Hormonal, and Behavioral Responses to Ipsapirone. Neuropsychopharmacology. 1997;17(6):382-90. PubMed PMID: 9397426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone. AU - Shiah,I S, AU - Yatham,L N, AU - Lam,R W, AU - Zis,A P, PY - 1997/12/16/pubmed PY - 1997/12/16/medline PY - 1997/12/16/entrez SP - 382 EP - 90 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 17 IS - 6 N2 - Hypothermic and hormonal responses to a challenge with a selective 5-HT1A receptor agonist ipsapirone are considered to provide an index of 5-HT1A receptor function in humans. To examine the effects of divalproex sodium (DVP) on 5-HT1A receptor function in humans, we measured the hypothermic, adrenocorticotropic hormone (ACTH) cortisol, and behavioral responses to ipsapirone in 10 healthy male volunteers. After obtaining a blood sample for baseline hormone levels and measuring body temperature, a single dose of 0.3 mg/kg of ipsapirone was given orally to all the subjects and further bloods and temperature reading were obtained at regular intervals for three hours. The ipsapirone challenge tests were repeated after the subjects had been treated with DVP (1000 mg/day) for one week. The results showed that the hypothermia induced by ipsapirone was significantly attenuated by the DVP treatment, whereas the ACTH/cortisol release and the behavioral responses following ipsapirone challenges were not altered. Our findings suggest that DVP may enhance 5-HT neurotransmission in humans via a subsensitization of 5-HT1A autoreceptors but does not appear to affect postsynaptic 5-HT1A receptors. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/9397426/Effects_of_divalproex_sodium_on_5_HT1A_receptor_function_in_healthy_human_males:_hypothermic_hormonal_and_behavioral_responses_to_ipsapirone_ L2 - http://dx.doi.org/10.1016/S0893-133X(97)00087-0 DB - PRIME DP - Unbound Medicine ER -