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Telomerase activity in human thyroid carcinomas originating from the follicular cells.
J Clin Endocrinol Metab. 1997 Dec; 82(12):4214-6.JC

Abstract

Telomerase activity is known to be absent from most normal and well-differentiated tissues, although being detectable in the vast majority of malignant tumors. An increasing number of reports demonstrate that telomerase may be activated in benign tumors, such as adenomas. We have investigated a series of normal and neoplastic thyroid tissues for the presence of telomerase activity. As expected, all normal thyroid tissues (n = 20) had no display of telomerase activity. Amongst cancers, the incidence of telomerase activity varied with the histological subtypes. Telomerase activity was present in only 3/15 cases (20%) of papillary carcinomas. Telomerase activity was more frequently detected in follicular (4/6) and in undifferentiated (2/3) carcinomas. Unexpectedly, one case (1/12) of adenoma contained high levels of telomerase activity. Taken together, these results indicate that telomerase may play some role in the pathogenesis of thyroid tumors, in particular in follicular and undifferentiated carcinomas that are known to have the most aggressive behavior.

Authors+Show Affiliations

Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire de Purpan, Toulouse, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9398742

Citation

Brousset, P, et al. "Telomerase Activity in Human Thyroid Carcinomas Originating From the Follicular Cells." The Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 12, 1997, pp. 4214-6.
Brousset P, Chaouche N, Leprat F, et al. Telomerase activity in human thyroid carcinomas originating from the follicular cells. J Clin Endocrinol Metab. 1997;82(12):4214-6.
Brousset, P., Chaouche, N., Leprat, F., Branet-Brousset, F., Trouette, H., Zenou, R. C., Merlio, J. P., & Delsol, G. (1997). Telomerase activity in human thyroid carcinomas originating from the follicular cells. The Journal of Clinical Endocrinology and Metabolism, 82(12), 4214-6.
Brousset P, et al. Telomerase Activity in Human Thyroid Carcinomas Originating From the Follicular Cells. J Clin Endocrinol Metab. 1997;82(12):4214-6. PubMed PMID: 9398742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity in human thyroid carcinomas originating from the follicular cells. AU - Brousset,P, AU - Chaouche,N, AU - Leprat,F, AU - Branet-Brousset,F, AU - Trouette,H, AU - Zenou,R C, AU - Merlio,J P, AU - Delsol,G, PY - 1997/12/17/pubmed PY - 1997/12/17/medline PY - 1997/12/17/entrez SP - 4214 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 82 IS - 12 N2 - Telomerase activity is known to be absent from most normal and well-differentiated tissues, although being detectable in the vast majority of malignant tumors. An increasing number of reports demonstrate that telomerase may be activated in benign tumors, such as adenomas. We have investigated a series of normal and neoplastic thyroid tissues for the presence of telomerase activity. As expected, all normal thyroid tissues (n = 20) had no display of telomerase activity. Amongst cancers, the incidence of telomerase activity varied with the histological subtypes. Telomerase activity was present in only 3/15 cases (20%) of papillary carcinomas. Telomerase activity was more frequently detected in follicular (4/6) and in undifferentiated (2/3) carcinomas. Unexpectedly, one case (1/12) of adenoma contained high levels of telomerase activity. Taken together, these results indicate that telomerase may play some role in the pathogenesis of thyroid tumors, in particular in follicular and undifferentiated carcinomas that are known to have the most aggressive behavior. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/9398742/Telomerase_activity_in_human_thyroid_carcinomas_originating_from_the_follicular_cells_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.82.12.4401 DB - PRIME DP - Unbound Medicine ER -