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Constipation in Parkinson's disease: objective assessment and response to psyllium.
Mov Disord. 1997 Nov; 12(6):946-51.MD

Abstract

We evaluated the reliability of patient history and the effect of psyllium on symptoms and colorectal function in 12 patients with Parkinson's disease (PD) and constipation. In all but two, constipation anteceded the development of parkinsonian symptoms. A comparison with prospectively obtained stool diaries confirmed the patients' reported constipation in 7 of the 12 patients. Those patients with confirmed constipation had lower stool weights and reported more straining at stool. Measures of colonic and anorectal function were similar in those who were truly constipated and those who were not. Among those PD subjects with confirmed constipation, psyllium increased stool frequency and weight but did not alter colonic transit or anorectal function. We conclude that prospectively obtained stool diaries should be employed to confirm constipation in PD and that psyllium produces both subjective and objective improvements in constipation related to PD.

Authors+Show Affiliations

Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-2000, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9399219

Citation

Ashraf, W, et al. "Constipation in Parkinson's Disease: Objective Assessment and Response to Psyllium." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 12, no. 6, 1997, pp. 946-51.
Ashraf W, Pfeiffer RF, Park F, et al. Constipation in Parkinson's disease: objective assessment and response to psyllium. Mov Disord. 1997;12(6):946-51.
Ashraf, W., Pfeiffer, R. F., Park, F., Lof, J., & Quigley, E. M. (1997). Constipation in Parkinson's disease: objective assessment and response to psyllium. Movement Disorders : Official Journal of the Movement Disorder Society, 12(6), 946-51.
Ashraf W, et al. Constipation in Parkinson's Disease: Objective Assessment and Response to Psyllium. Mov Disord. 1997;12(6):946-51. PubMed PMID: 9399219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Constipation in Parkinson's disease: objective assessment and response to psyllium. AU - Ashraf,W, AU - Pfeiffer,R F, AU - Park,F, AU - Lof,J, AU - Quigley,E M, PY - 1997/12/17/pubmed PY - 1997/12/17/medline PY - 1997/12/17/entrez SP - 946 EP - 51 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 12 IS - 6 N2 - We evaluated the reliability of patient history and the effect of psyllium on symptoms and colorectal function in 12 patients with Parkinson's disease (PD) and constipation. In all but two, constipation anteceded the development of parkinsonian symptoms. A comparison with prospectively obtained stool diaries confirmed the patients' reported constipation in 7 of the 12 patients. Those patients with confirmed constipation had lower stool weights and reported more straining at stool. Measures of colonic and anorectal function were similar in those who were truly constipated and those who were not. Among those PD subjects with confirmed constipation, psyllium increased stool frequency and weight but did not alter colonic transit or anorectal function. We conclude that prospectively obtained stool diaries should be employed to confirm constipation in PD and that psyllium produces both subjective and objective improvements in constipation related to PD. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/9399219/Constipation_in_Parkinson's_disease:_objective_assessment_and_response_to_psyllium_ L2 - https://doi.org/10.1002/mds.870120617 DB - PRIME DP - Unbound Medicine ER -