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Is duodenal gastric metaplasia a consequence of Helicobacter pylori infection in children?
Am J Gastroenterol. 1997 Dec; 92(12):2216-9.AJ

Abstract

BACKGROUND

Duodenal gastric metaplasia (DGM) is commonly found in association with Helicobacter pylori (Hp)-associated gastritis in adults. DGM is also considered a risk factor for duodenal ulcer development. The prevalence of DGM in children and its association with gastritis, duodenitis, or the presence of Hp organisms is not clear. We investigated the prevalence of DGM in children and explore its association with several possible risk factors, including age, gender, gastritis, duodenitis, or Hp presence in the gastric antrum.

METHODS

A retrospective analysis of 173 upper endoscopy procedures performed between 1993 and 1995 at Cabell Huntington Hospital, Huntington, WV, was done. Gastric and duodenal biopsies were stained with Giemsa for Hp detection, periodic acid-Schiff for DGM, and hematoxylin and eosin for histologic assessment. Gastric mucosal inflammation was graded according to Sydney criteria.

RESULTS

Duodenal gastric metaplasia was identified in 23 of 173 (13%) patients. Duodenitis but not age, gender, gastritis, or the presence of Hp in the gastric antrum was associated with DGM development. In 4 of 23 DGM foci, Hp was identified.

CONCLUSIONS

In children, DGM is not the consequence of Hp infection.

Authors+Show Affiliations

Department of Pediatrics, Cabell Huntington Hospital, Marshall University School of Medicine, Huntington, West Virginia 25701-0195, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9399756

Citation

Elitsur, Y, and W E. Triest. "Is Duodenal Gastric Metaplasia a Consequence of Helicobacter Pylori Infection in Children?" The American Journal of Gastroenterology, vol. 92, no. 12, 1997, pp. 2216-9.
Elitsur Y, Triest WE. Is duodenal gastric metaplasia a consequence of Helicobacter pylori infection in children? Am J Gastroenterol. 1997;92(12):2216-9.
Elitsur, Y., & Triest, W. E. (1997). Is duodenal gastric metaplasia a consequence of Helicobacter pylori infection in children? The American Journal of Gastroenterology, 92(12), 2216-9.
Elitsur Y, Triest WE. Is Duodenal Gastric Metaplasia a Consequence of Helicobacter Pylori Infection in Children. Am J Gastroenterol. 1997;92(12):2216-9. PubMed PMID: 9399756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is duodenal gastric metaplasia a consequence of Helicobacter pylori infection in children? AU - Elitsur,Y, AU - Triest,W E, PY - 1997/12/17/pubmed PY - 1997/12/17/medline PY - 1997/12/17/entrez SP - 2216 EP - 9 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 92 IS - 12 N2 - BACKGROUND: Duodenal gastric metaplasia (DGM) is commonly found in association with Helicobacter pylori (Hp)-associated gastritis in adults. DGM is also considered a risk factor for duodenal ulcer development. The prevalence of DGM in children and its association with gastritis, duodenitis, or the presence of Hp organisms is not clear. We investigated the prevalence of DGM in children and explore its association with several possible risk factors, including age, gender, gastritis, duodenitis, or Hp presence in the gastric antrum. METHODS: A retrospective analysis of 173 upper endoscopy procedures performed between 1993 and 1995 at Cabell Huntington Hospital, Huntington, WV, was done. Gastric and duodenal biopsies were stained with Giemsa for Hp detection, periodic acid-Schiff for DGM, and hematoxylin and eosin for histologic assessment. Gastric mucosal inflammation was graded according to Sydney criteria. RESULTS: Duodenal gastric metaplasia was identified in 23 of 173 (13%) patients. Duodenitis but not age, gender, gastritis, or the presence of Hp in the gastric antrum was associated with DGM development. In 4 of 23 DGM foci, Hp was identified. CONCLUSIONS: In children, DGM is not the consequence of Hp infection. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9399756/Is_duodenal_gastric_metaplasia_a_consequence_of_Helicobacter_pylori_infection_in_children DB - PRIME DP - Unbound Medicine ER -