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Effect of insulin on blood rheology in non-diabetic subjects and in patients with Type 2 diabetes mellitus.
Diabet Med 1997; 14(11):959-63DM

Abstract

We evaluated the effect of insulin on platelet function, blood viscosity, and filterability in healthy subjects and in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Fifteen diabetic patients were free from cardiovascular complications (group A), while the other 15 patients had both clinical and measured evidence of coronary or peripheral vascular disease (group B); 15 non-diabetic subjects served as controls. On blood samples taken without stasis, maximal platelet aggregation to 1.25 micromol l(-1) ADP, blood and plasma viscosity, and blood filterability were measured in basal conditions, and after incubation of blood, plasma or platelet-rich plasma with insulin at two physiological concentrations (120 and 480 pmol l(-1)). Compared with healthy subjects, the diabetic patients of group B had higher values of blood (p < 0.01) and plasma (p < 0.05) viscosity, and platelet aggregation response to ADP (p < 0.01), as well as lower values of blood filterability (p < 0.01). The diabetic patients of group A had values intermediate between normal subjects and the patients of group B. In non-diabetic subjects, insulin significantly decreased platelet aggregation and blood viscosity at low shear rates (22.5 s(-1)) (p < 0.01 for both), and had no significant effects on other parameters. In the diabetic patients of group A, insulin decreased blood viscosity at high (225 s(-1)) rates of shear (p < 0.01) and increased blood filterability (p < 0.01). The effects of insulin were not dose-related. In the diabetic patients of group B, none of the parameters evaluated was significantly influenced by insulin. Type 2 diabetic patients present many abnormalities of the rheologic properties of blood. The beneficial effects of insulin on platelet aggregation and blood viscosity are not evident in Type 2 diabetic patients, especially those with vascular complications and this may be relevant to the development of those complications.

Authors+Show Affiliations

Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9400920

Citation

Coppola, L, et al. "Effect of Insulin On Blood Rheology in Non-diabetic Subjects and in Patients With Type 2 Diabetes Mellitus." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 14, no. 11, 1997, pp. 959-63.
Coppola L, Verrazzo G, La Marca C, et al. Effect of insulin on blood rheology in non-diabetic subjects and in patients with Type 2 diabetes mellitus. Diabet Med. 1997;14(11):959-63.
Coppola, L., Verrazzo, G., La Marca, C., Ziccardi, P., Grassia, A., Tirelli, A., & Giugliano, D. (1997). Effect of insulin on blood rheology in non-diabetic subjects and in patients with Type 2 diabetes mellitus. Diabetic Medicine : a Journal of the British Diabetic Association, 14(11), pp. 959-63.
Coppola L, et al. Effect of Insulin On Blood Rheology in Non-diabetic Subjects and in Patients With Type 2 Diabetes Mellitus. Diabet Med. 1997;14(11):959-63. PubMed PMID: 9400920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of insulin on blood rheology in non-diabetic subjects and in patients with Type 2 diabetes mellitus. AU - Coppola,L, AU - Verrazzo,G, AU - La Marca,C, AU - Ziccardi,P, AU - Grassia,A, AU - Tirelli,A, AU - Giugliano,D, PY - 1997/12/24/pubmed PY - 1997/12/24/medline PY - 1997/12/24/entrez SP - 959 EP - 63 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 14 IS - 11 N2 - We evaluated the effect of insulin on platelet function, blood viscosity, and filterability in healthy subjects and in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Fifteen diabetic patients were free from cardiovascular complications (group A), while the other 15 patients had both clinical and measured evidence of coronary or peripheral vascular disease (group B); 15 non-diabetic subjects served as controls. On blood samples taken without stasis, maximal platelet aggregation to 1.25 micromol l(-1) ADP, blood and plasma viscosity, and blood filterability were measured in basal conditions, and after incubation of blood, plasma or platelet-rich plasma with insulin at two physiological concentrations (120 and 480 pmol l(-1)). Compared with healthy subjects, the diabetic patients of group B had higher values of blood (p < 0.01) and plasma (p < 0.05) viscosity, and platelet aggregation response to ADP (p < 0.01), as well as lower values of blood filterability (p < 0.01). The diabetic patients of group A had values intermediate between normal subjects and the patients of group B. In non-diabetic subjects, insulin significantly decreased platelet aggregation and blood viscosity at low shear rates (22.5 s(-1)) (p < 0.01 for both), and had no significant effects on other parameters. In the diabetic patients of group A, insulin decreased blood viscosity at high (225 s(-1)) rates of shear (p < 0.01) and increased blood filterability (p < 0.01). The effects of insulin were not dose-related. In the diabetic patients of group B, none of the parameters evaluated was significantly influenced by insulin. Type 2 diabetic patients present many abnormalities of the rheologic properties of blood. The beneficial effects of insulin on platelet aggregation and blood viscosity are not evident in Type 2 diabetic patients, especially those with vascular complications and this may be relevant to the development of those complications. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/9400920/Effect_of_insulin_on_blood_rheology_in_non_diabetic_subjects_and_in_patients_with_Type_2_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -