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Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome.
Acta Gastroenterol Latinoam. 1997; 27(4):247-51.AG

Abstract

BACKGROUND

Growing evidence points to irritable bowel syndrome physiologically as a disease of the enteric nervous system characterised by hypermotility. The aim of this study was to investigate the action of pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract on basal and post-prandial recto-anal motility of 40 irritable bowel syndrome patients in a random, double blind and placebo controlled trial.

METHODS

Pinaverium bromide (50 mg) or placebo was taken orally t.i.d. with food. Myoelectrical and mechanical activities of the rectum and the internal anal sphincter were recorded before treatment for 2 h in the fasting state and for an additional 2 h post-prandial.

RESULTS

Post-prandial rectal spike amplitude and frequency as well as the spontaneous recto-anal inhibitory reflex frequency decreased after pinaverium bromide (P < 0.01) but not after placebo.

CONCLUSIONS

These results suggest that the calcium channel blockers acting selectively on the gastrointestinal tract may have a therapeutic role in patients with irritable bowel syndrome.

Authors+Show Affiliations

Experimental Medicine and Motility Unit, Ministry of Health, Mexico City General Hospital; Mexico D.F. awadrichard@iserve.net.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9401097

Citation

Awad, R A., et al. "Reduction of Post-prandial Motility By Pinaverium Bromide a Calcium Channel Blocker Acting Selectively On the Gastrointestinal Tract in Patients With Irritable Bowel Syndrome." Acta Gastroenterologica Latinoamericana, vol. 27, no. 4, 1997, pp. 247-51.
Awad RA, Cordova VH, Dibildox M, et al. Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome. Acta Gastroenterol Latinoam. 1997;27(4):247-51.
Awad, R. A., Cordova, V. H., Dibildox, M., Santiago, R., & Camacho, S. (1997). Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome. Acta Gastroenterologica Latinoamericana, 27(4), 247-51.
Awad RA, et al. Reduction of Post-prandial Motility By Pinaverium Bromide a Calcium Channel Blocker Acting Selectively On the Gastrointestinal Tract in Patients With Irritable Bowel Syndrome. Acta Gastroenterol Latinoam. 1997;27(4):247-51. PubMed PMID: 9401097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome. AU - Awad,R A, AU - Cordova,V H, AU - Dibildox,M, AU - Santiago,R, AU - Camacho,S, PY - 1997/1/1/pubmed PY - 1997/12/24/medline PY - 1997/1/1/entrez SP - 247 EP - 51 JF - Acta gastroenterologica Latinoamericana JO - Acta Gastroenterol Latinoam VL - 27 IS - 4 N2 - BACKGROUND: Growing evidence points to irritable bowel syndrome physiologically as a disease of the enteric nervous system characterised by hypermotility. The aim of this study was to investigate the action of pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract on basal and post-prandial recto-anal motility of 40 irritable bowel syndrome patients in a random, double blind and placebo controlled trial. METHODS: Pinaverium bromide (50 mg) or placebo was taken orally t.i.d. with food. Myoelectrical and mechanical activities of the rectum and the internal anal sphincter were recorded before treatment for 2 h in the fasting state and for an additional 2 h post-prandial. RESULTS: Post-prandial rectal spike amplitude and frequency as well as the spontaneous recto-anal inhibitory reflex frequency decreased after pinaverium bromide (P < 0.01) but not after placebo. CONCLUSIONS: These results suggest that the calcium channel blockers acting selectively on the gastrointestinal tract may have a therapeutic role in patients with irritable bowel syndrome. SN - 0300-9033 UR - https://www.unboundmedicine.com/medline/citation/9401097/Reduction_of_post_prandial_motility_by_pinaverium_bromide_a_calcium_channel_blocker_acting_selectively_on_the_gastrointestinal_tract_in_patients_with_irritable_bowel_syndrome_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -