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Strategies and tactics in the treatment of chronic depression.
J Clin Psychiatry. 1997; 58 Suppl 13:14-22.JC

Abstract

Chronic depressions include major depressive disorder, recurrent, without full interepisode recovery; major depressive disorder, currently in a chronic (i.e., > or = 2 years) episode; double depression; dysthymic disorder; and those depressive disorders--not otherwise specified (NOS)--that are persistent or predictably recurrent with substantial disability. Strategic treatment decisions include (1) whether to treat with medication, psychotherapy, ECT, or other methods; (2) selection among specific agents with long-term efficacy and tolerability (preferably established by randomized controlled trials); (3) selection of the next treatment should the initial treatment fail or be found intolerable; and (4) deciding whether to provide maintenance treatment. Tactical decisions are those needed to optimally implement the strategies selected; for example, (1) how to optimally dose, (2) how long to continue an acute phase treatment trial, (3) how to measure outcome, and (4) how to identify and manage subsequent symptomatic breakthroughs or side effects (which may also require revisions in the initial strategies). Some antidepressant medications evidence efficacy and safety in acute phase treatment of the chronically depressed, but continuation and maintenance phase treatments for these patients are less well investigated and deserve further study. The clinical implications of what is known to date for managing these patients are discussed.

Authors+Show Affiliations

Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas 75235, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9402915

Citation

Rush, A J., and M E. Thase. "Strategies and Tactics in the Treatment of Chronic Depression." The Journal of Clinical Psychiatry, vol. 58 Suppl 13, 1997, pp. 14-22.
Rush AJ, Thase ME. Strategies and tactics in the treatment of chronic depression. J Clin Psychiatry. 1997;58 Suppl 13:14-22.
Rush, A. J., & Thase, M. E. (1997). Strategies and tactics in the treatment of chronic depression. The Journal of Clinical Psychiatry, 58 Suppl 13, 14-22.
Rush AJ, Thase ME. Strategies and Tactics in the Treatment of Chronic Depression. J Clin Psychiatry. 1997;58 Suppl 13:14-22. PubMed PMID: 9402915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strategies and tactics in the treatment of chronic depression. AU - Rush,A J, AU - Thase,M E, PY - 1997/1/1/pubmed PY - 1997/12/24/medline PY - 1997/1/1/entrez SP - 14 EP - 22 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 58 Suppl 13 N2 - Chronic depressions include major depressive disorder, recurrent, without full interepisode recovery; major depressive disorder, currently in a chronic (i.e., > or = 2 years) episode; double depression; dysthymic disorder; and those depressive disorders--not otherwise specified (NOS)--that are persistent or predictably recurrent with substantial disability. Strategic treatment decisions include (1) whether to treat with medication, psychotherapy, ECT, or other methods; (2) selection among specific agents with long-term efficacy and tolerability (preferably established by randomized controlled trials); (3) selection of the next treatment should the initial treatment fail or be found intolerable; and (4) deciding whether to provide maintenance treatment. Tactical decisions are those needed to optimally implement the strategies selected; for example, (1) how to optimally dose, (2) how long to continue an acute phase treatment trial, (3) how to measure outcome, and (4) how to identify and manage subsequent symptomatic breakthroughs or side effects (which may also require revisions in the initial strategies). Some antidepressant medications evidence efficacy and safety in acute phase treatment of the chronically depressed, but continuation and maintenance phase treatments for these patients are less well investigated and deserve further study. The clinical implications of what is known to date for managing these patients are discussed. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/9402915/Strategies_and_tactics_in_the_treatment_of_chronic_depression_ L2 - http://www.psychiatrist.com/jcp/article/pages/1997/v58s13/v58s1304.aspx DB - PRIME DP - Unbound Medicine ER -