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Interspousal transmission of GB virus-C/hepatitis G virus: a comparison with hepatitis C virus.
J Med Virol. 1997 Dec; 53(4):348-53.JM

Abstract

Although infection with GB virus-C/hepatitis G virus (GBV-C/HGV) by blood transfusion is well documented, little is known about the other routes of transmission. The prevalence of GBV-C/HGV infection in spouses of index patients and the related risk factors were studied. Hepatitis C virus (HCV) and GBV-C/HGV infections were studied in spouses of 100 patients with hepatitis C, of whom 12 were found to be also positive for GBV-C/HGV RNA. For couples both with GBV-C/ HGV viremia, nucleotide sequences of the divergent envelope region were analyzed by phylogenetic tree constructions. For HCV infection, anti-HCV was found in 14 (14%) of the 100 spouses. Five spouses (42%) of the 12 patients with dual infection of GBV-C/HGV and HCV had evidence of GBV-C/HGV infection, three had viral RNA, and two had antibodies to a recombinant HGV envelope protein E2. Nucleotide sequence comparison and phylogenetic tree analysis of the genome in the GBV-C/HGV infected couple revealed the isolates to be closely related. These results suggest that spouses of patients with GBV-C/HGV infection are at a higher risk of acquiring GBV-C/HGV as compared with HCV, and they should be educated to avoid GBV-C/HGV infection from their spouses, in case GBV-C/HGV is shown to be pathogenic.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9407382

Citation

Kao, J H., et al. "Interspousal Transmission of GB virus-C/hepatitis G Virus: a Comparison With Hepatitis C Virus." Journal of Medical Virology, vol. 53, no. 4, 1997, pp. 348-53.
Kao JH, Liu CJ, Chen PJ, et al. Interspousal transmission of GB virus-C/hepatitis G virus: a comparison with hepatitis C virus. J Med Virol. 1997;53(4):348-53.
Kao, J. H., Liu, C. J., Chen, P. J., Chen, W., Hsiang, S. C., Lai, M. Y., & Chen, D. S. (1997). Interspousal transmission of GB virus-C/hepatitis G virus: a comparison with hepatitis C virus. Journal of Medical Virology, 53(4), 348-53.
Kao JH, et al. Interspousal Transmission of GB virus-C/hepatitis G Virus: a Comparison With Hepatitis C Virus. J Med Virol. 1997;53(4):348-53. PubMed PMID: 9407382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interspousal transmission of GB virus-C/hepatitis G virus: a comparison with hepatitis C virus. AU - Kao,J H, AU - Liu,C J, AU - Chen,P J, AU - Chen,W, AU - Hsiang,S C, AU - Lai,M Y, AU - Chen,D S, PY - 1998/1/4/pubmed PY - 2000/6/20/medline PY - 1998/1/4/entrez SP - 348 EP - 53 JF - Journal of medical virology JO - J Med Virol VL - 53 IS - 4 N2 - Although infection with GB virus-C/hepatitis G virus (GBV-C/HGV) by blood transfusion is well documented, little is known about the other routes of transmission. The prevalence of GBV-C/HGV infection in spouses of index patients and the related risk factors were studied. Hepatitis C virus (HCV) and GBV-C/HGV infections were studied in spouses of 100 patients with hepatitis C, of whom 12 were found to be also positive for GBV-C/HGV RNA. For couples both with GBV-C/ HGV viremia, nucleotide sequences of the divergent envelope region were analyzed by phylogenetic tree constructions. For HCV infection, anti-HCV was found in 14 (14%) of the 100 spouses. Five spouses (42%) of the 12 patients with dual infection of GBV-C/HGV and HCV had evidence of GBV-C/HGV infection, three had viral RNA, and two had antibodies to a recombinant HGV envelope protein E2. Nucleotide sequence comparison and phylogenetic tree analysis of the genome in the GBV-C/HGV infected couple revealed the isolates to be closely related. These results suggest that spouses of patients with GBV-C/HGV infection are at a higher risk of acquiring GBV-C/HGV as compared with HCV, and they should be educated to avoid GBV-C/HGV infection from their spouses, in case GBV-C/HGV is shown to be pathogenic. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/9407382/Interspousal_transmission_of_GB_virus_C/hepatitis_G_virus:_a_comparison_with_hepatitis_C_virus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1997&volume=53&issue=4&spage=348 DB - PRIME DP - Unbound Medicine ER -