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Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in east Arnhem Land, Australia.
Nat Toxins. 1997; 5(4):136-40.NT

Abstract

We report a retrospective study of the clinical signs and symptoms associated with a point-source outbreak of fish poisoning that occurred with a fish captured from the Arafura Sea, northern Australia. Twenty cases (16 Aboriginal and 4 non-Aboriginal) characteristic of ciguatera, including 4 inpatients and 16 outpatients from the Gove Hospital, were identified based on the pattern of clinical symptoms and signs after ingestion of a large coral cod from a known ciguatera-prone coral reef. In the absence of a serologic test for the victim, laboratory analysis of a 230-g sample of the coral cod (Cephalopolis miniatus), using both mouse bioassay and HPLC/mass spectometry, showed that Pacific ciguatoxin-1 was the principal toxin involved. Intravenous mannitol was administered to one patient without clear benefit. Risk factors for ciguatera poisoning are ingestion of larger portions of reef fish from ciguatera-prone areas. Despite apparent local awareness of the distribution and etiology of the disease, large common-source outbreaks of ciguatera still occur.

Authors+Show Affiliations

Medical Unit, Alice Springs Hospital, Northern Territory, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9407555

Citation

Lucas, R E., et al. "Pacific Ciguatoxin-1 Associated With a Large Common-source Outbreak of Ciguatera in East Arnhem Land, Australia." Natural Toxins, vol. 5, no. 4, 1997, pp. 136-40.
Lucas RE, Lewis RJ, Taylor JM. Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in east Arnhem Land, Australia. Nat Toxins. 1997;5(4):136-40.
Lucas, R. E., Lewis, R. J., & Taylor, J. M. (1997). Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in east Arnhem Land, Australia. Natural Toxins, 5(4), 136-40.
Lucas RE, Lewis RJ, Taylor JM. Pacific Ciguatoxin-1 Associated With a Large Common-source Outbreak of Ciguatera in East Arnhem Land, Australia. Nat Toxins. 1997;5(4):136-40. PubMed PMID: 9407555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in east Arnhem Land, Australia. AU - Lucas,R E, AU - Lewis,R J, AU - Taylor,J M, PY - 1997/1/1/pubmed PY - 1998/1/4/medline PY - 1997/1/1/entrez SP - 136 EP - 40 JF - Natural toxins JO - Nat Toxins VL - 5 IS - 4 N2 - We report a retrospective study of the clinical signs and symptoms associated with a point-source outbreak of fish poisoning that occurred with a fish captured from the Arafura Sea, northern Australia. Twenty cases (16 Aboriginal and 4 non-Aboriginal) characteristic of ciguatera, including 4 inpatients and 16 outpatients from the Gove Hospital, were identified based on the pattern of clinical symptoms and signs after ingestion of a large coral cod from a known ciguatera-prone coral reef. In the absence of a serologic test for the victim, laboratory analysis of a 230-g sample of the coral cod (Cephalopolis miniatus), using both mouse bioassay and HPLC/mass spectometry, showed that Pacific ciguatoxin-1 was the principal toxin involved. Intravenous mannitol was administered to one patient without clear benefit. Risk factors for ciguatera poisoning are ingestion of larger portions of reef fish from ciguatera-prone areas. Despite apparent local awareness of the distribution and etiology of the disease, large common-source outbreaks of ciguatera still occur. SN - 1056-9014 UR - https://www.unboundmedicine.com/medline/citation/9407555/Pacific_ciguatoxin_1_associated_with_a_large_common_source_outbreak_of_ciguatera_in_east_Arnhem_Land_Australia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1056-9014&date=1997&volume=5&issue=4&spage=136 DB - PRIME DP - Unbound Medicine ER -