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Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
Cancer Res. 1997 Dec 15; 57(24):5446-51.CR

Abstract

Although pituitary adenomas are monoclonal proliferations, somatic mutations involving genes that govern cell proliferation or hormone production have been difficult to identify. The genetic etiology of most pituitary tumors, therefore, remains unknown. Pituitary adenomas can develop sporadically or as a part of multiple endocrine neoplasia type 1 (MEN1). Recently, the gene responsible for MEN1 was cloned. To elucidate the potential etiological role of the MEN1 gene in pituitary tumorigenesis, 39 sporadic pituitary adenomas from 38 patients and 1 pituitary adenoma from a familial MEN1 patient were examined for MEN1 gene mutations and allelic deletions. Four of 39 sporadic pituitary adenomas showed a deletion of one copy of the MEN1 gene, and a specific MEN1 gene mutation in the remaining gene copy was detected in 2 of these tumors. The corresponding germ-line sequence was normal in all sporadic cases. A specific MEN1 mutation was detected in a pituitary adenoma and corresponding germ-line DNA in a patient with familial MEN1. An allelic deletion of the remaining copy of the MEN1 gene was also found in the patient's tumor. Genetic alterations of the MEN1 gene represent a candidate pathogenetic mechanism of pituitary tumorigenesis. The data suggest that somatic MEN1 gene mutations and deletions play a causative role in the development of a subgroup of sporadic pituitary adenomas.

Authors+Show Affiliations

Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9407947

Citation

Zhuang, Z, et al. "Mutations of the MEN1 Tumor Suppressor Gene in Pituitary Tumors." Cancer Research, vol. 57, no. 24, 1997, pp. 5446-51.
Zhuang Z, Ezzat SZ, Vortmeyer AO, et al. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res. 1997;57(24):5446-51.
Zhuang, Z., Ezzat, S. Z., Vortmeyer, A. O., Weil, R., Oldfield, E. H., Park, W. S., Pack, S., Huang, S., Agarwal, S. K., Guru, S. C., Manickam, P., Debelenko, L. V., Kester, M. B., Olufemi, S. E., Heppner, C., Crabtree, J. S., Burns, A. L., Spiegel, A. M., Marx, S. J., ... Lubensky, I. A. (1997). Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Research, 57(24), 5446-51.
Zhuang Z, et al. Mutations of the MEN1 Tumor Suppressor Gene in Pituitary Tumors. Cancer Res. 1997 Dec 15;57(24):5446-51. PubMed PMID: 9407947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutations of the MEN1 tumor suppressor gene in pituitary tumors. AU - Zhuang,Z, AU - Ezzat,S Z, AU - Vortmeyer,A O, AU - Weil,R, AU - Oldfield,E H, AU - Park,W S, AU - Pack,S, AU - Huang,S, AU - Agarwal,S K, AU - Guru,S C, AU - Manickam,P, AU - Debelenko,L V, AU - Kester,M B, AU - Olufemi,S E, AU - Heppner,C, AU - Crabtree,J S, AU - Burns,A L, AU - Spiegel,A M, AU - Marx,S J, AU - Chandrasekharappa,S C, AU - Collins,F S, AU - Emmert-Buck,M R, AU - Liotta,L A, AU - Asa,S L, AU - Lubensky,I A, PY - 1998/1/4/pubmed PY - 1998/1/4/medline PY - 1998/1/4/entrez SP - 5446 EP - 51 JF - Cancer research JO - Cancer Res VL - 57 IS - 24 N2 - Although pituitary adenomas are monoclonal proliferations, somatic mutations involving genes that govern cell proliferation or hormone production have been difficult to identify. The genetic etiology of most pituitary tumors, therefore, remains unknown. Pituitary adenomas can develop sporadically or as a part of multiple endocrine neoplasia type 1 (MEN1). Recently, the gene responsible for MEN1 was cloned. To elucidate the potential etiological role of the MEN1 gene in pituitary tumorigenesis, 39 sporadic pituitary adenomas from 38 patients and 1 pituitary adenoma from a familial MEN1 patient were examined for MEN1 gene mutations and allelic deletions. Four of 39 sporadic pituitary adenomas showed a deletion of one copy of the MEN1 gene, and a specific MEN1 gene mutation in the remaining gene copy was detected in 2 of these tumors. The corresponding germ-line sequence was normal in all sporadic cases. A specific MEN1 mutation was detected in a pituitary adenoma and corresponding germ-line DNA in a patient with familial MEN1. An allelic deletion of the remaining copy of the MEN1 gene was also found in the patient's tumor. Genetic alterations of the MEN1 gene represent a candidate pathogenetic mechanism of pituitary tumorigenesis. The data suggest that somatic MEN1 gene mutations and deletions play a causative role in the development of a subgroup of sporadic pituitary adenomas. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9407947/Mutations_of_the_MEN1_tumor_suppressor_gene_in_pituitary_tumors_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9407947 DB - PRIME DP - Unbound Medicine ER -