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Associations of oral contraceptive use with serum lipids and lipoproteins in young women: the Bogalusa Heart Study.
Ann Epidemiol 1997; 7(8):561-7AE

Abstract

PURPOSE

Cross-sectional and longitudinal associations of serum lipids and lipoproteins with oral contraceptive (OC) use were examined among white and black women aged 18-27 years in 1985-86 and 1988-1991 in the Bogalusa Heart Study, a study of cardiovascular disease in a Southern community.

METHODS

Analyses of covariance.

RESULTS

In 1985-1986, white OC users had significantly (p < 0.05) higher adjusted mean total and low density lipoprotein (LDL) cholesterols, and lower high density lipoprotein (HDL) cholesterol compared with nonusers; black OC users had higher triglycerides and LDL cholesterol, and lower HDL cholesterol. In 1988-1991, white OC users had higher total cholesterol, triglycerides, and LDL cholesterol, while black OC users had higher triglycerides. OC use was unrelated to mean HDL cholesterol levels in 1988-1991; however, a lower percentage of white OC users than nonusers in 1988-1991 had HDL cholesterol levels < 35 mg/dl. Longitudinally, white OC nonusers at baseline who used OCs at follow-up had significant increases from baseline levels in total cholesterol, triglycerides, and very low density lipoprotein (VLDL) and LDL cholesterols; black women showed an increase only in LDL cholesterol. White women who stopped using OCs by follow-up had a decrease in VLDL and LDL cholesterols, and an increase in HDL cholesterol. White OC users at both exams also had a significant increase in HDL cholesterol, whereas women who began using OCs by follow-up did not.

CONCLUSIONS

The unfavorable lipid profile associated with OC use was not apparent upon discontinued use. Lack of an adverse effect of OC use on HDL cholesterol at follow-up may be the result of changing formulations, and requires further examination.

Authors+Show Affiliations

Tulane Center for Cardiovascular Health, Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9408552

Citation

Greenlund, K J., et al. "Associations of Oral Contraceptive Use With Serum Lipids and Lipoproteins in Young Women: the Bogalusa Heart Study." Annals of Epidemiology, vol. 7, no. 8, 1997, pp. 561-7.
Greenlund KJ, Webber LS, Srinivasan S, et al. Associations of oral contraceptive use with serum lipids and lipoproteins in young women: the Bogalusa Heart Study. Ann Epidemiol. 1997;7(8):561-7.
Greenlund, K. J., Webber, L. S., Srinivasan, S., Wattigney, W., Johnson, C., & Berenson, G. S. (1997). Associations of oral contraceptive use with serum lipids and lipoproteins in young women: the Bogalusa Heart Study. Annals of Epidemiology, 7(8), pp. 561-7.
Greenlund KJ, et al. Associations of Oral Contraceptive Use With Serum Lipids and Lipoproteins in Young Women: the Bogalusa Heart Study. Ann Epidemiol. 1997;7(8):561-7. PubMed PMID: 9408552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of oral contraceptive use with serum lipids and lipoproteins in young women: the Bogalusa Heart Study. AU - Greenlund,K J, AU - Webber,L S, AU - Srinivasan,S, AU - Wattigney,W, AU - Johnson,C, AU - Berenson,G S, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez KW - Americas KW - Biology KW - Blacks KW - Cholesterol KW - Contraception KW - Contraceptive Methods--side effects KW - Correlation Studies KW - Cultural Background KW - Demographic Factors KW - Developed Countries KW - Ethnic Groups KW - Family Planning KW - Lipid Metabolic Effects KW - Lipids KW - Longitudinal Studies KW - Louisiana KW - North America KW - Northern America KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives--side effects KW - Physiology KW - Population KW - Population Characteristics KW - Research Methodology KW - Research Report KW - Statistical Studies KW - Studies KW - United States KW - Whites SP - 561 EP - 7 JF - Annals of epidemiology JO - Ann Epidemiol VL - 7 IS - 8 N2 - PURPOSE: Cross-sectional and longitudinal associations of serum lipids and lipoproteins with oral contraceptive (OC) use were examined among white and black women aged 18-27 years in 1985-86 and 1988-1991 in the Bogalusa Heart Study, a study of cardiovascular disease in a Southern community. METHODS: Analyses of covariance. RESULTS: In 1985-1986, white OC users had significantly (p < 0.05) higher adjusted mean total and low density lipoprotein (LDL) cholesterols, and lower high density lipoprotein (HDL) cholesterol compared with nonusers; black OC users had higher triglycerides and LDL cholesterol, and lower HDL cholesterol. In 1988-1991, white OC users had higher total cholesterol, triglycerides, and LDL cholesterol, while black OC users had higher triglycerides. OC use was unrelated to mean HDL cholesterol levels in 1988-1991; however, a lower percentage of white OC users than nonusers in 1988-1991 had HDL cholesterol levels < 35 mg/dl. Longitudinally, white OC nonusers at baseline who used OCs at follow-up had significant increases from baseline levels in total cholesterol, triglycerides, and very low density lipoprotein (VLDL) and LDL cholesterols; black women showed an increase only in LDL cholesterol. White women who stopped using OCs by follow-up had a decrease in VLDL and LDL cholesterols, and an increase in HDL cholesterol. White OC users at both exams also had a significant increase in HDL cholesterol, whereas women who began using OCs by follow-up did not. CONCLUSIONS: The unfavorable lipid profile associated with OC use was not apparent upon discontinued use. Lack of an adverse effect of OC use on HDL cholesterol at follow-up may be the result of changing formulations, and requires further examination. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/9408552/Associations_of_oral_contraceptive_use_with_serum_lipids_and_lipoproteins_in_young_women:_the_Bogalusa_Heart_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047279797001191 DB - PRIME DP - Unbound Medicine ER -