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Dopamine receptor antagonists fail to prevent induction of cocaine sensitization.
Neuropsychopharmacology. 1998 Jan; 18(1):26-40.N

Abstract

We investigated the ability of dopamine D1 and D2 class receptor antagonists to prevent the induction of behavioral sensitization to cocaine. The D2 receptor antagonist eticlopride failed to prevent the induction of cocaine sensitization. An intermediate dose of the D1 receptor antagonist SCH 23390 (0.1 mg/kg) appeared to prevent the induction of cocaine sensitization when tested after 3 days of withdrawal, but sensitization was clearly evident after 10 days of withdrawal. High doses of SCH 23390 alone produced supersensitivity to the behavioral effects of cocaine and to the inhibitory effects of D1 receptor agonists on nucleus accumbens neurons. Co-administration of eticlopride and SCH 23390 also failed to prevent the induction of cocaine sensitization. SCH 23390, but not eticlopride, prevented the expression of cocaine sensitization. We conclude that dopamine receptors are either not involved in the induction of cocaine sensitization or that redundant mechanisms exist to produce the same neuroadaptations.

Authors+Show Affiliations

Department of Neuroscience, Finch University of Health Sciences, Chicago Medical School, Illinois 60064-3095, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9408916

Citation

White, F J., et al. "Dopamine Receptor Antagonists Fail to Prevent Induction of Cocaine Sensitization." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 18, no. 1, 1998, pp. 26-40.
White FJ, Joshi A, Koeltzow TE, et al. Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. Neuropsychopharmacology. 1998;18(1):26-40.
White, F. J., Joshi, A., Koeltzow, T. E., & Hu, X. T. (1998). Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 18(1), 26-40.
White FJ, et al. Dopamine Receptor Antagonists Fail to Prevent Induction of Cocaine Sensitization. Neuropsychopharmacology. 1998;18(1):26-40. PubMed PMID: 9408916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. AU - White,F J, AU - Joshi,A, AU - Koeltzow,T E, AU - Hu,X T, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez SP - 26 EP - 40 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 18 IS - 1 N2 - We investigated the ability of dopamine D1 and D2 class receptor antagonists to prevent the induction of behavioral sensitization to cocaine. The D2 receptor antagonist eticlopride failed to prevent the induction of cocaine sensitization. An intermediate dose of the D1 receptor antagonist SCH 23390 (0.1 mg/kg) appeared to prevent the induction of cocaine sensitization when tested after 3 days of withdrawal, but sensitization was clearly evident after 10 days of withdrawal. High doses of SCH 23390 alone produced supersensitivity to the behavioral effects of cocaine and to the inhibitory effects of D1 receptor agonists on nucleus accumbens neurons. Co-administration of eticlopride and SCH 23390 also failed to prevent the induction of cocaine sensitization. SCH 23390, but not eticlopride, prevented the expression of cocaine sensitization. We conclude that dopamine receptors are either not involved in the induction of cocaine sensitization or that redundant mechanisms exist to produce the same neuroadaptations. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/9408916/Dopamine_receptor_antagonists_fail_to_prevent_induction_of_cocaine_sensitization_ DB - PRIME DP - Unbound Medicine ER -