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[The proportion of molecular forms of gonadotropins changes in patients with polycystic ovaries].
Ginecol Obstet Mex. 1997 Sep; 65:382-5.GO

Abstract

It is known that protein hormones circulate as different molecular forms and the relative proportion of these isoforms changes according to endocrine milieu. In particular gonadotropins, both LH and FSH, isoforms suffer variations related to the estrogen levels; thus sera obstained from menopausal women show a predominance of larger molecular forms which are considered as having lesser biological activity and the administration of estrogen replacement therapy is followed by the appearance of intermediate molecular forms possessing higher biological activity. This chormatographic pattern with predominance of intermediate isoforms is typical at midcycle in sera from normal women at the periovulatory stage. Present study showed that sera obtained from anovulatory women, such as patients with polycystic ovaries a predominance of larger and smaller molecular weight isoforms, exhibiting a chromatographic pattern different from that observed in normal women. It is speculate that there is some imbalance between the ovarian steroid synthesis and gonadotropin production in the stage of tertiary structural conformation.

Authors+Show Affiliations

Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional, IMSS, México, D.F.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

9410809

Citation

Mason, M, et al. "[The Proportion of Molecular Forms of Gonadotropins Changes in Patients With Polycystic Ovaries]." Ginecologia Y Obstetricia De Mexico, vol. 65, 1997, pp. 382-5.
Mason M, Hernández-Valencia M, Zárate A, et al. [The proportion of molecular forms of gonadotropins changes in patients with polycystic ovaries]. Ginecol Obstet Mex. 1997;65:382-5.
Mason, M., Hernández-Valencia, M., Zárate, A., Fonseca, M. E., & Ochoa, R. (1997). [The proportion of molecular forms of gonadotropins changes in patients with polycystic ovaries]. Ginecologia Y Obstetricia De Mexico, 65, 382-5.
Mason M, et al. [The Proportion of Molecular Forms of Gonadotropins Changes in Patients With Polycystic Ovaries]. Ginecol Obstet Mex. 1997;65:382-5. PubMed PMID: 9410809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The proportion of molecular forms of gonadotropins changes in patients with polycystic ovaries]. AU - Mason,M, AU - Hernández-Valencia,M, AU - Zárate,A, AU - Fonseca,M E, AU - Ochoa,R, PY - 1997/12/31/pubmed PY - 1997/12/31/medline PY - 1997/12/31/entrez SP - 382 EP - 5 JF - Ginecologia y obstetricia de Mexico JO - Ginecol Obstet Mex VL - 65 N2 - It is known that protein hormones circulate as different molecular forms and the relative proportion of these isoforms changes according to endocrine milieu. In particular gonadotropins, both LH and FSH, isoforms suffer variations related to the estrogen levels; thus sera obstained from menopausal women show a predominance of larger molecular forms which are considered as having lesser biological activity and the administration of estrogen replacement therapy is followed by the appearance of intermediate molecular forms possessing higher biological activity. This chormatographic pattern with predominance of intermediate isoforms is typical at midcycle in sera from normal women at the periovulatory stage. Present study showed that sera obtained from anovulatory women, such as patients with polycystic ovaries a predominance of larger and smaller molecular weight isoforms, exhibiting a chromatographic pattern different from that observed in normal women. It is speculate that there is some imbalance between the ovarian steroid synthesis and gonadotropin production in the stage of tertiary structural conformation. SN - 0300-9041 UR - https://www.unboundmedicine.com/medline/citation/9410809/[The_proportion_of_molecular_forms_of_gonadotropins_changes_in_patients_with_polycystic_ovaries]_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -