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Does hyperparathyroidism cause hypergastrinemia?
Surgery. 1976 Aug; 80(2):231-7.S

Abstract

To define the relationship between hyperparathyroidism (HPT) and gastric function, 31 patients with HPT were prospectively studied before and 2 to 25 months after parathyroidectomy. The gastrin response to a standard test meal (STM), the basal acid output (BAO), and the peak acid output (PAO) were determined. Parathormone and calcium were elevated in all patients and returned to normal following parathyroidectomy. The mean fasting gastrin concentration, mean integrated gastrin response (IGR) to feeding, mean basal acid output (BAO), and mean peak acid output (PAO) were not changed by successful parathyroidectomy. There was no significant correlation between gastrin concentration or gastrin response to feeding and gastric acid secretion. Eight of 31 HPT patients had fasting gastrin concentrations above normal preoperatively and remained so postoperatively. Hypergastrinemia in six of these eight patients could be explained by the Zollinger-Ellison (Z-E) syndrome or chronic atrophic gastritis. The hypothesis that peptic ulcer disease seen in some HPT patients is the result of calcium-induced hypergastrinemia causing gastric hypersecretion is not supported by this study.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

941095

Citation

Wilson, S D., et al. "Does Hyperparathyroidism Cause Hypergastrinemia?" Surgery, vol. 80, no. 2, 1976, pp. 231-7.
Wilson SD, Singh RB, Kalkhoff RK. Does hyperparathyroidism cause hypergastrinemia? Surgery. 1976;80(2):231-7.
Wilson, S. D., Singh, R. B., & Kalkhoff, R. K. (1976). Does hyperparathyroidism cause hypergastrinemia? Surgery, 80(2), 231-7.
Wilson SD, Singh RB, Kalkhoff RK. Does Hyperparathyroidism Cause Hypergastrinemia. Surgery. 1976;80(2):231-7. PubMed PMID: 941095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does hyperparathyroidism cause hypergastrinemia? AU - Wilson,S D, AU - Singh,R B, AU - Kalkhoff,R K, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 231 EP - 7 JF - Surgery JO - Surgery VL - 80 IS - 2 N2 - To define the relationship between hyperparathyroidism (HPT) and gastric function, 31 patients with HPT were prospectively studied before and 2 to 25 months after parathyroidectomy. The gastrin response to a standard test meal (STM), the basal acid output (BAO), and the peak acid output (PAO) were determined. Parathormone and calcium were elevated in all patients and returned to normal following parathyroidectomy. The mean fasting gastrin concentration, mean integrated gastrin response (IGR) to feeding, mean basal acid output (BAO), and mean peak acid output (PAO) were not changed by successful parathyroidectomy. There was no significant correlation between gastrin concentration or gastrin response to feeding and gastric acid secretion. Eight of 31 HPT patients had fasting gastrin concentrations above normal preoperatively and remained so postoperatively. Hypergastrinemia in six of these eight patients could be explained by the Zollinger-Ellison (Z-E) syndrome or chronic atrophic gastritis. The hypothesis that peptic ulcer disease seen in some HPT patients is the result of calcium-induced hypergastrinemia causing gastric hypersecretion is not supported by this study. SN - 0039-6060 UR - https://www.unboundmedicine.com/medline/citation/941095/Does_hyperparathyroidism_cause_hypergastrinemia DB - PRIME DP - Unbound Medicine ER -