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Histamine release from rat neutrophils and mast cells as induced by ionophore--a pharmacological approach--.
Jpn J Pharmacol. 1979 Aug; 29(4):653-9.JJ

Abstract

A comparative study was carried out on the histamine release from rat neutrophils and mast cells by calcium ionohpore A 23 187 (Ionophore). A maximum release of histamine from neutrophils was induced by 10(-6) g/ml Ionophore and that from mast cells was 5 x 10(-6) g/ml. A fairly good correlation was found between the 45Ca incorporation into and the histamine release from both cells. The Ionophore-induced histamine release from both cells was decreased in Ca2+-free Tyrode's solution and by pretreatment with 0.05 M EDTA. Effects of different drugs on Ionophore-induced histamine release from neutrophils were similar to those seen in mast cells. Dibutyl cyclic adenosine monophosphate, theophylline, isoproterenol and prostaglandin E1 had not or only a slight inhibition on the release. The dose dependent inhibition of release was observed with disodium cromoglycate, N-(3',4'-dimethoxycinnamoyl) anthranilic acid and disodium baicalein phosphate, in experiments using both cells. Colchicine did not inhibit the reaction in these cells, however phosphatidylserine enhanced the reaction. On the other hand, the effect of concanavalin A was different in each type of cells, the release from mast cells was inhibited while the release from neutrophils was potentiated. These findings suggest the similarity of biochemical events in Ionophore-induced histamine release from neutrophils and mast cells.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

94116

Citation

Nagai, H, and A Koda. "Histamine Release From Rat Neutrophils and Mast Cells as Induced By Ionophore--a Pharmacological Approach--." Japanese Journal of Pharmacology, vol. 29, no. 4, 1979, pp. 653-9.
Nagai H, Koda A. Histamine release from rat neutrophils and mast cells as induced by ionophore--a pharmacological approach--. Jpn J Pharmacol. 1979;29(4):653-9.
Nagai, H., & Koda, A. (1979). Histamine release from rat neutrophils and mast cells as induced by ionophore--a pharmacological approach--. Japanese Journal of Pharmacology, 29(4), 653-9.
Nagai H, Koda A. Histamine Release From Rat Neutrophils and Mast Cells as Induced By Ionophore--a Pharmacological Approach--. Jpn J Pharmacol. 1979;29(4):653-9. PubMed PMID: 94116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine release from rat neutrophils and mast cells as induced by ionophore--a pharmacological approach--. AU - Nagai,H, AU - Koda,A, PY - 1979/8/1/pubmed PY - 1979/8/1/medline PY - 1979/8/1/entrez SP - 653 EP - 9 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 29 IS - 4 N2 - A comparative study was carried out on the histamine release from rat neutrophils and mast cells by calcium ionohpore A 23 187 (Ionophore). A maximum release of histamine from neutrophils was induced by 10(-6) g/ml Ionophore and that from mast cells was 5 x 10(-6) g/ml. A fairly good correlation was found between the 45Ca incorporation into and the histamine release from both cells. The Ionophore-induced histamine release from both cells was decreased in Ca2+-free Tyrode's solution and by pretreatment with 0.05 M EDTA. Effects of different drugs on Ionophore-induced histamine release from neutrophils were similar to those seen in mast cells. Dibutyl cyclic adenosine monophosphate, theophylline, isoproterenol and prostaglandin E1 had not or only a slight inhibition on the release. The dose dependent inhibition of release was observed with disodium cromoglycate, N-(3',4'-dimethoxycinnamoyl) anthranilic acid and disodium baicalein phosphate, in experiments using both cells. Colchicine did not inhibit the reaction in these cells, however phosphatidylserine enhanced the reaction. On the other hand, the effect of concanavalin A was different in each type of cells, the release from mast cells was inhibited while the release from neutrophils was potentiated. These findings suggest the similarity of biochemical events in Ionophore-induced histamine release from neutrophils and mast cells. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/94116/Histamine_release_from_rat_neutrophils_and_mast_cells_as_induced_by_ionophore__a_pharmacological_approach___ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/29.653?from=PubMed DB - PRIME DP - Unbound Medicine ER -