Tags

Type your tag names separated by a space and hit enter

Significant correlation of telomerase activity in thyroid papillary carcinomas with cell differentiation, proliferation and extrathyroidal extension.
Jpn J Cancer Res. 1997 Oct; 88(10):965-70.JJ

Abstract

Telomerase activity was examined by telomeric repeat amplification protocol assay in thyroid disease states, including adenomas and carcinomas, and correlated with clinicopathological features. Of a total of 26 papillary carcinomas, 16 cases (61.5%) were positive, with the poorly differentiated subtype being predominant (P < 0.05). A significantly more shortened terminal restriction fragment length (P < 0.05), higher incidence of extrathyroidal extension (P < 0.001), and more elevated Ki-67 labeling indices (P < 0.002) were also found in telomerase-positive than in telomerase-negative papillary carcinomas. Of four follicular carcinomas, 3 cases (75.0%) were positive. Positive telomerase activity in follicular adenomas (9/23 cases, 39.1%) and lymphocytic thyroiditis (12/22 cases, 54.5%) appeared to be mainly caused by infiltrating lymphocytes. However, three cases of atypical adenoma with relatively increased Ki-67 labeling indices were positive, suggesting a possibility of malignant potential. The good correlations with extrathyroidal invasiveness, Ki-67 labeling indices and poor differentiation of papillary carcinomas, established by multivariate analysis, suggest that this parameter might have potential application in the estimation of tumor progression and prognosis, and in clinical management.

Authors+Show Affiliations

Department of Pathology, School of Medicine, Kitasato University, Kanagawa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9414658

Citation

Okayasu, I, et al. "Significant Correlation of Telomerase Activity in Thyroid Papillary Carcinomas With Cell Differentiation, Proliferation and Extrathyroidal Extension." Japanese Journal of Cancer Research : Gann, vol. 88, no. 10, 1997, pp. 965-70.
Okayasu I, Osakabe T, Fujiwara M, et al. Significant correlation of telomerase activity in thyroid papillary carcinomas with cell differentiation, proliferation and extrathyroidal extension. Jpn J Cancer Res. 1997;88(10):965-70.
Okayasu, I., Osakabe, T., Fujiwara, M., Fukuda, H., Kato, M., & Oshimura, M. (1997). Significant correlation of telomerase activity in thyroid papillary carcinomas with cell differentiation, proliferation and extrathyroidal extension. Japanese Journal of Cancer Research : Gann, 88(10), 965-70.
Okayasu I, et al. Significant Correlation of Telomerase Activity in Thyroid Papillary Carcinomas With Cell Differentiation, Proliferation and Extrathyroidal Extension. Jpn J Cancer Res. 1997;88(10):965-70. PubMed PMID: 9414658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significant correlation of telomerase activity in thyroid papillary carcinomas with cell differentiation, proliferation and extrathyroidal extension. AU - Okayasu,I, AU - Osakabe,T, AU - Fujiwara,M, AU - Fukuda,H, AU - Kato,M, AU - Oshimura,M, PY - 1998/1/1/pubmed PY - 1998/1/1/medline PY - 1998/1/1/entrez SP - 965 EP - 70 JF - Japanese journal of cancer research : Gann JO - Jpn J Cancer Res VL - 88 IS - 10 N2 - Telomerase activity was examined by telomeric repeat amplification protocol assay in thyroid disease states, including adenomas and carcinomas, and correlated with clinicopathological features. Of a total of 26 papillary carcinomas, 16 cases (61.5%) were positive, with the poorly differentiated subtype being predominant (P < 0.05). A significantly more shortened terminal restriction fragment length (P < 0.05), higher incidence of extrathyroidal extension (P < 0.001), and more elevated Ki-67 labeling indices (P < 0.002) were also found in telomerase-positive than in telomerase-negative papillary carcinomas. Of four follicular carcinomas, 3 cases (75.0%) were positive. Positive telomerase activity in follicular adenomas (9/23 cases, 39.1%) and lymphocytic thyroiditis (12/22 cases, 54.5%) appeared to be mainly caused by infiltrating lymphocytes. However, three cases of atypical adenoma with relatively increased Ki-67 labeling indices were positive, suggesting a possibility of malignant potential. The good correlations with extrathyroidal invasiveness, Ki-67 labeling indices and poor differentiation of papillary carcinomas, established by multivariate analysis, suggest that this parameter might have potential application in the estimation of tumor progression and prognosis, and in clinical management. SN - 0910-5050 UR - https://www.unboundmedicine.com/medline/citation/9414658/Significant_correlation_of_telomerase_activity_in_thyroid_papillary_carcinomas_with_cell_differentiation_proliferation_and_extrathyroidal_extension_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9414658/ DB - PRIME DP - Unbound Medicine ER -