Abstract
OBJECTIVE
To compare the efficacy of finasteride and spironolactone in the treatment of idiopathic hirsutism.
DESIGN
Prospective, randomized, single-blind study.
SETTING
A tertiary hirsutism clinic.
PATIENT(S)
Forty women with idiopathic hirsutism were selected.
INTERVENTION(S)
Patients were assigned randomly to receive either 5 mg of finasteride or 100 mg of spironolactone for 9 months.
MAIN OUTCOME MEASURE(S)
Hirsutism scores were measured according to the Ferriman-Gallwey scoring system, and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters.
RESULT(S)
Hirsutism scores were decreased significantly in both groups at the end of 9 months. The mean percent change (+/- SD) in hirsutism scores in the finasteride and spironolactone groups was as follows: 5.91% +/- 7.18% and 20.60% +/- 12.59% at 3 months, 10.61% +/- 12.18% and 32.57% +/- 15.68% at 6 months, and 15.15% +/- 15.38% and 42.36% +/- 12.31% at 9 months, respectively. There was a significantly better response with spironolactone treatment at the end of 9 months. Eleven (55%) of 20 patients in the spironolactone group experienced side effects. However, none of them stopped treatment because of side effects.
CONCLUSION(S)
The present data suggest that both finasteride and spironolactone are effective in the treatment of idiopathic hirsutism. However, it appears that the spironolactone group responded significantly better.
TY - JOUR
T1 - Comparison of finasteride versus spironolactone in the treatment of idiopathic hirsutism.
AU - Erenus,M,
AU - Yücelten,D,
AU - Durmuşoğlu,F,
AU - Gürbüz,O,
PY - 1998/1/7/pubmed
PY - 1998/1/7/medline
PY - 1998/1/7/entrez
SP - 1000
EP - 3
JF - Fertility and sterility
JO - Fertil Steril
VL - 68
IS - 6
N2 - OBJECTIVE: To compare the efficacy of finasteride and spironolactone in the treatment of idiopathic hirsutism. DESIGN: Prospective, randomized, single-blind study. SETTING: A tertiary hirsutism clinic. PATIENT(S): Forty women with idiopathic hirsutism were selected. INTERVENTION(S): Patients were assigned randomly to receive either 5 mg of finasteride or 100 mg of spironolactone for 9 months. MAIN OUTCOME MEASURE(S): Hirsutism scores were measured according to the Ferriman-Gallwey scoring system, and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. RESULT(S): Hirsutism scores were decreased significantly in both groups at the end of 9 months. The mean percent change (+/- SD) in hirsutism scores in the finasteride and spironolactone groups was as follows: 5.91% +/- 7.18% and 20.60% +/- 12.59% at 3 months, 10.61% +/- 12.18% and 32.57% +/- 15.68% at 6 months, and 15.15% +/- 15.38% and 42.36% +/- 12.31% at 9 months, respectively. There was a significantly better response with spironolactone treatment at the end of 9 months. Eleven (55%) of 20 patients in the spironolactone group experienced side effects. However, none of them stopped treatment because of side effects. CONCLUSION(S): The present data suggest that both finasteride and spironolactone are effective in the treatment of idiopathic hirsutism. However, it appears that the spironolactone group responded significantly better.
SN - 0015-0282
UR - https://www.unboundmedicine.com/medline/citation/9418687/Comparison_of_finasteride_versus_spironolactone_in_the_treatment_of_idiopathic_hirsutism_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028297003713
DB - PRIME
DP - Unbound Medicine
ER -
