Tags

Type your tag names separated by a space and hit enter

Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice.
J Clin Invest. 1998 Jan 01; 101(1):62-7.JCI

Abstract

Alopecia areata is a tissue-restricted autoimmune disease of the hair follicle, which results in hair loss and baldness. It is often psychologically devastating. The role of T lymphocytes in this disorder was investigated with cell transfer experiments. Scalp explants from patients were transplanted to severe combined immunodeficiency (SCID) mice and injected with autologous T lymphocytes isolated from involved scalp. T lymphocytes which had been cultured with hair follicle homogenate along with antigen-presenting cells were capable of inducing the changes of alopecia areata, including hair loss and perifollicular infiltrates of T cells, along with HLA-DR and ICAM-1 expression of the follicular epithelium. Similar changes were not noted in grafts injected with scalp-derived T cells that had not been cultured with follicular homogenate. These data indicate that alopecia areata is mediated by T cells which recognize a follicular autoantigen.

Links

PMC Free PDF
PMC Free Full Text
Aggregator Full Text

Authors+Show Affiliations

Gilhar A
Skin Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. gilhar@techunix.technion.ac.il
Ullmann Y
No affiliation info available
Berkutzki T
No affiliation info available
Assy B
No affiliation info available
Kalish RS
No affiliation info available

MeSH

AdultAlopecia AreataAnimalsAutoimmune DiseasesCells, CulturedFemaleHLA-DR AntigensHumansIntercellular Adhesion Molecule-1MaleMiceMice, SCIDScalpT-Lymphocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9421466

Citation

Gilhar, A, et al. "Autoimmune Hair Loss (alopecia Areata) Transferred By T Lymphocytes to Human Scalp Explants On SCID Mice." The Journal of Clinical Investigation, vol. 101, no. 1, 1998, pp. 62-7.
Gilhar A, Ullmann Y, Berkutzki T, et al. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest. 1998;101(1):62-7.
Gilhar, A., Ullmann, Y., Berkutzki, T., Assy, B., & Kalish, R. S. (1998). Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. The Journal of Clinical Investigation, 101(1), 62-7.
Gilhar A, et al. Autoimmune Hair Loss (alopecia Areata) Transferred By T Lymphocytes to Human Scalp Explants On SCID Mice. J Clin Invest. 1998 Jan 1;101(1):62-7. PubMed PMID: 9421466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. AU - Gilhar,A, AU - Ullmann,Y, AU - Berkutzki,T, AU - Assy,B, AU - Kalish,R S, PY - 1998/2/14/pubmed PY - 1998/2/14/medline PY - 1998/2/14/entrez SP - 62 EP - 7 JF - The Journal of clinical investigation JO - J Clin Invest VL - 101 IS - 1 N2 - Alopecia areata is a tissue-restricted autoimmune disease of the hair follicle, which results in hair loss and baldness. It is often psychologically devastating. The role of T lymphocytes in this disorder was investigated with cell transfer experiments. Scalp explants from patients were transplanted to severe combined immunodeficiency (SCID) mice and injected with autologous T lymphocytes isolated from involved scalp. T lymphocytes which had been cultured with hair follicle homogenate along with antigen-presenting cells were capable of inducing the changes of alopecia areata, including hair loss and perifollicular infiltrates of T cells, along with HLA-DR and ICAM-1 expression of the follicular epithelium. Similar changes were not noted in grafts injected with scalp-derived T cells that had not been cultured with follicular homogenate. These data indicate that alopecia areata is mediated by T cells which recognize a follicular autoantigen. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/9421466/Autoimmune_hair_loss__alopecia_areata__transferred_by_T_lymphocytes_to_human_scalp_explants_on_SCID_mice_ L2 - https://doi.org/10.1172/JCI551 DB - PRIME DP - Unbound Medicine ER -