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The human aerodigestive tract and gastroesophageal reflux: an evolutionary perspective.
Am J Med. 1997 Nov 24; 103(5A):2S-8S.AJ

Abstract

In order to appreciate fully the nature of supraesophageal complications of gastroesophageal reflux in humans, it is essential to view the problem within an evolutionary framework. Examination of the aerodigestive tract anatomy of our mammalian relatives shows that this region in humans is highly derived as compared to other mammals. Among the specializations that adult humans exhibit is a caudal position of the larynx, which results in a permanently expanded oropharynx. These anatomical features underlie our distinctive breathing and swallowing patterns and provide the substrate that allows for the production of articulate speech. While the selection factors that have shaped human evolution obviously favored our derived aerodigestive tract, aspects of this anatomy appear particularly unsuited to accommodate gastroesophageal reflux. Indeed, our unique aerodigestive tract morphology may predispose us to an array of supraesophageal complications of gastroesophageal reflux.

Authors+Show Affiliations

Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

9422615

Citation

Laitman, J T., and J S. Reidenberg. "The Human Aerodigestive Tract and Gastroesophageal Reflux: an Evolutionary Perspective." The American Journal of Medicine, vol. 103, no. 5A, 1997, 2S-8S.
Laitman JT, Reidenberg JS. The human aerodigestive tract and gastroesophageal reflux: an evolutionary perspective. Am J Med. 1997;103(5A):2S-8S.
Laitman, J. T., & Reidenberg, J. S. (1997). The human aerodigestive tract and gastroesophageal reflux: an evolutionary perspective. The American Journal of Medicine, 103(5A), 2S-8S.
Laitman JT, Reidenberg JS. The Human Aerodigestive Tract and Gastroesophageal Reflux: an Evolutionary Perspective. Am J Med. 1997 Nov 24;103(5A):2S-8S. PubMed PMID: 9422615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The human aerodigestive tract and gastroesophageal reflux: an evolutionary perspective. AU - Laitman,J T, AU - Reidenberg,J S, PY - 1998/1/9/pubmed PY - 1998/1/9/medline PY - 1998/1/9/entrez SP - 2S EP - 8S JF - The American journal of medicine JO - Am J Med VL - 103 IS - 5A N2 - In order to appreciate fully the nature of supraesophageal complications of gastroesophageal reflux in humans, it is essential to view the problem within an evolutionary framework. Examination of the aerodigestive tract anatomy of our mammalian relatives shows that this region in humans is highly derived as compared to other mammals. Among the specializations that adult humans exhibit is a caudal position of the larynx, which results in a permanently expanded oropharynx. These anatomical features underlie our distinctive breathing and swallowing patterns and provide the substrate that allows for the production of articulate speech. While the selection factors that have shaped human evolution obviously favored our derived aerodigestive tract, aspects of this anatomy appear particularly unsuited to accommodate gastroesophageal reflux. Indeed, our unique aerodigestive tract morphology may predispose us to an array of supraesophageal complications of gastroesophageal reflux. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/9422615/The_human_aerodigestive_tract_and_gastroesophageal_reflux:_an_evolutionary_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(97)00313-6 DB - PRIME DP - Unbound Medicine ER -