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Antinuclear antibody and HLA-B27 positive uveitis: combination of two diseases?
Br J Ophthalmol. 1997 Sep; 81(9):771-3.BJ

Abstract

AIMS/BACKGROUND

Anterior uveitis associated with juvenile chronic arthritis concerns two different clinical entities: firstly, antinuclear antibody (ANA) positive patients who have a chronic anterior uveitis with severe complications and often a poor visual prognosis; secondly, usually HLA-B27 positive children, predominantly boys, with unilateral recurrent anterior uveitis. Three patients are described who had a combination of clinical and laboratory features of both diseases.

METHODS

Retrospective clinical and laboratory analysis of three patients.

RESULTS

Ocular features in the three patients combined the clinical picture of ANA positive chronic anterior uveitis during early childhood with the clinical features of HLA-B27 unilateral acute anterior uveitis during adolescence. The patients fulfilled the diagnostic criteria of juvenile chronic arthritis, and they had no ankylosing spondylitis. All three patients had the HLA-B*2705 subtype.

CONCLUSIONS

Whether the association of ANA positive chronic anterior uveitis and HLA-B27 unilateral acute anterior uveitis is a coincidence or represents a distinct clinical entity is not yet clear.

Authors+Show Affiliations

Department of Ophthalmology, F C Donders Institute, Academic Hospital, Utrecht, Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9422931

Citation

Bosch-Driessen, E H., et al. "Antinuclear Antibody and HLA-B27 Positive Uveitis: Combination of Two Diseases?" The British Journal of Ophthalmology, vol. 81, no. 9, 1997, pp. 771-3.
Bosch-Driessen EH, Lardy NM, Rothova A. Antinuclear antibody and HLA-B27 positive uveitis: combination of two diseases? Br J Ophthalmol. 1997;81(9):771-3.
Bosch-Driessen, E. H., Lardy, N. M., & Rothova, A. (1997). Antinuclear antibody and HLA-B27 positive uveitis: combination of two diseases? The British Journal of Ophthalmology, 81(9), 771-3.
Bosch-Driessen EH, Lardy NM, Rothova A. Antinuclear Antibody and HLA-B27 Positive Uveitis: Combination of Two Diseases. Br J Ophthalmol. 1997;81(9):771-3. PubMed PMID: 9422931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinuclear antibody and HLA-B27 positive uveitis: combination of two diseases? AU - Bosch-Driessen,E H, AU - Lardy,N M, AU - Rothova,A, PY - 1998/1/10/pubmed PY - 1998/1/10/medline PY - 1998/1/10/entrez SP - 771 EP - 3 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 81 IS - 9 N2 - AIMS/BACKGROUND: Anterior uveitis associated with juvenile chronic arthritis concerns two different clinical entities: firstly, antinuclear antibody (ANA) positive patients who have a chronic anterior uveitis with severe complications and often a poor visual prognosis; secondly, usually HLA-B27 positive children, predominantly boys, with unilateral recurrent anterior uveitis. Three patients are described who had a combination of clinical and laboratory features of both diseases. METHODS: Retrospective clinical and laboratory analysis of three patients. RESULTS: Ocular features in the three patients combined the clinical picture of ANA positive chronic anterior uveitis during early childhood with the clinical features of HLA-B27 unilateral acute anterior uveitis during adolescence. The patients fulfilled the diagnostic criteria of juvenile chronic arthritis, and they had no ankylosing spondylitis. All three patients had the HLA-B*2705 subtype. CONCLUSIONS: Whether the association of ANA positive chronic anterior uveitis and HLA-B27 unilateral acute anterior uveitis is a coincidence or represents a distinct clinical entity is not yet clear. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/9422931/Antinuclear_antibody_and_HLA_B27_positive_uveitis:_combination_of_two_diseases L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=9422931 DB - PRIME DP - Unbound Medicine ER -