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Variation in incidences of tuberculosis in subgroups of South African gold miners.
Occup Environ Med. 1997 Sep; 54(9):636-41.OE

Abstract

OBJECTIVES

To determine risk factors and to identify groups at high risk of tuberculosis (TB) among South African gold miners.

METHODS

A retrospective cohort analysis was carried out with hospital and personnel databases on a random sample of the workforce of Freegold Mines, served by Ernest Oppenheimer Hospital, Welkom, South Africa. The outcome measure of interest was a reported first episode of TB while employed at Freegold. A person-years analysis was carried out to estimate incidence ratios between different categories of age group, period, cumulative service, mining occupation, and silicosis status. A separate analysis was carried out on a subgroup of men (non-random) whose HIV status was known.

RESULTS

The main finding of the study was that TB was more strongly associated with age than expected with a rate ratio of reported incidence of 21 for the oldest age group compared with the youngest, after adjustment for period, cumulative service, occupation, and silicosis status. There was also a significant association between TB and occupations such as drilling with a rate ratio of 2.3 compared with low dust surface and maintenance workers, after adjustment for age, period, cumulative service, and silicosis. Analysis of the HIV tested subgroup showed that these results are unlikely to be the result of confounding due to HIV infection. Prevalence of HIV in this group has been rising sharply since 1991, but the increase was slowing towards the end of the study period.

CONCLUSION

A profile of mineworkers who are at high risk of TB can be defined by age, mining occupation, silicosis status, and HIV infection with predicted rates of 100/1000 person-years. TB screening programmes should take special cognisance of high risk groups of gold miners.

Authors+Show Affiliations

Epidemiology Research Unit, Braamfontein, South Africa.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9423575

Citation

Kleinschmidt, I, and G Churchyard. "Variation in Incidences of Tuberculosis in Subgroups of South African Gold Miners." Occupational and Environmental Medicine, vol. 54, no. 9, 1997, pp. 636-41.
Kleinschmidt I, Churchyard G. Variation in incidences of tuberculosis in subgroups of South African gold miners. Occup Environ Med. 1997;54(9):636-41.
Kleinschmidt, I., & Churchyard, G. (1997). Variation in incidences of tuberculosis in subgroups of South African gold miners. Occupational and Environmental Medicine, 54(9), 636-41.
Kleinschmidt I, Churchyard G. Variation in Incidences of Tuberculosis in Subgroups of South African Gold Miners. Occup Environ Med. 1997;54(9):636-41. PubMed PMID: 9423575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variation in incidences of tuberculosis in subgroups of South African gold miners. AU - Kleinschmidt,I, AU - Churchyard,G, PY - 1998/1/10/pubmed PY - 1998/1/10/medline PY - 1998/1/10/entrez KW - Africa KW - Africa South Of The Sahara KW - Biology KW - Cohort Analysis KW - Developing Countries KW - Diseases KW - English Speaking Africa KW - Hiv Infections KW - Incidence KW - Infections KW - Measurement KW - Research Methodology KW - Research Report KW - Retrospective Studies KW - Risk Factors KW - South Africa KW - Southern Africa KW - Studies KW - Tuberculosis KW - Viral Diseases SP - 636 EP - 41 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 54 IS - 9 N2 - OBJECTIVES: To determine risk factors and to identify groups at high risk of tuberculosis (TB) among South African gold miners. METHODS: A retrospective cohort analysis was carried out with hospital and personnel databases on a random sample of the workforce of Freegold Mines, served by Ernest Oppenheimer Hospital, Welkom, South Africa. The outcome measure of interest was a reported first episode of TB while employed at Freegold. A person-years analysis was carried out to estimate incidence ratios between different categories of age group, period, cumulative service, mining occupation, and silicosis status. A separate analysis was carried out on a subgroup of men (non-random) whose HIV status was known. RESULTS: The main finding of the study was that TB was more strongly associated with age than expected with a rate ratio of reported incidence of 21 for the oldest age group compared with the youngest, after adjustment for period, cumulative service, occupation, and silicosis status. There was also a significant association between TB and occupations such as drilling with a rate ratio of 2.3 compared with low dust surface and maintenance workers, after adjustment for age, period, cumulative service, and silicosis. Analysis of the HIV tested subgroup showed that these results are unlikely to be the result of confounding due to HIV infection. Prevalence of HIV in this group has been rising sharply since 1991, but the increase was slowing towards the end of the study period. CONCLUSION: A profile of mineworkers who are at high risk of TB can be defined by age, mining occupation, silicosis status, and HIV infection with predicted rates of 100/1000 person-years. TB screening programmes should take special cognisance of high risk groups of gold miners. SN - 1351-0711 UR - https://www.unboundmedicine.com/medline/citation/9423575/Variation_in_incidences_of_tuberculosis_in_subgroups_of_South_African_gold_miners_ L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&pmid=9423575 DB - PRIME DP - Unbound Medicine ER -