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Cross-neutralization of Thai cobra (Naja kaouthia) and spitting cobra (Naja siamensis) venoms by Thai cobra antivenom.
Toxicon. 1997 Nov; 35(11):1649-51.T

Abstract

The neutralizing capacity of antivenom prepared against Thai cobra (Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 LD50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom.

Authors+Show Affiliations

Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9428112

Citation

Khow, O, et al. "Cross-neutralization of Thai Cobra (Naja Kaouthia) and Spitting Cobra (Naja Siamensis) Venoms By Thai Cobra Antivenom." Toxicon : Official Journal of the International Society On Toxinology, vol. 35, no. 11, 1997, pp. 1649-51.
Khow O, Pakmanee N, Chanhome L, et al. Cross-neutralization of Thai cobra (Naja kaouthia) and spitting cobra (Naja siamensis) venoms by Thai cobra antivenom. Toxicon. 1997;35(11):1649-51.
Khow, O., Pakmanee, N., Chanhome, L., Sriprapat, S., Omori-Satoh, T., & Sitprija, V. (1997). Cross-neutralization of Thai cobra (Naja kaouthia) and spitting cobra (Naja siamensis) venoms by Thai cobra antivenom. Toxicon : Official Journal of the International Society On Toxinology, 35(11), 1649-51.
Khow O, et al. Cross-neutralization of Thai Cobra (Naja Kaouthia) and Spitting Cobra (Naja Siamensis) Venoms By Thai Cobra Antivenom. Toxicon. 1997;35(11):1649-51. PubMed PMID: 9428112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-neutralization of Thai cobra (Naja kaouthia) and spitting cobra (Naja siamensis) venoms by Thai cobra antivenom. AU - Khow,O, AU - Pakmanee,N, AU - Chanhome,L, AU - Sriprapat,S, AU - Omori-Satoh,T, AU - Sitprija,V, PY - 1998/1/15/pubmed PY - 1998/1/15/medline PY - 1998/1/15/entrez SP - 1649 EP - 51 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 35 IS - 11 N2 - The neutralizing capacity of antivenom prepared against Thai cobra (Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 LD50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/9428112/Cross_neutralization_of_Thai_cobra__Naja_kaouthia__and_spitting_cobra__Naja_siamensis__venoms_by_Thai_cobra_antivenom_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041010197000354 DB - PRIME DP - Unbound Medicine ER -