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A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet.
J Am Coll Nutr. 1997 Dec; 16(6):551-61.JA

Abstract

OBJECTIVE

We investigated the effect of egg feeding in 161 hypercholesterolemic (HC) or combined hyperlipidemic (CHL) free-living subjects taught the NCEP Step I Diet.

METHODS

Subjects had LDL-C between 3.36 and 4.91 mmol/L (130 and 190 mg/dL). HC subjects had triglyceride concentrations < 75th %-ile, CHL > or = 75th %-ile. Six weeks after instituting the Step I Diet, subjects were randomized to two eggs or egg substitute daily for 12 weeks.

RESULTS

Mean dietary intake (9-day food records) was within NCEP guidelines and 131 subjects finished with stable weight and adherence > 80%. Placebo group lipoprotein lipids were unchanged at study end for both HC (n = 35) and CHL (n = 21) subjects. Egg-fed HC subjects (n = 44) increased LDL-C nonsignificantly, 0.07 mmol/L (3 mg/dL) (p = 0.49). Egg-fed CHL subjects (n = 31) increased LDL-C 0.31 mmol/L (12 mg/dL) (p < 0.001). HDL-C increased significantly in both HC and CHL groups, 0.10 and 0.08 mmol/L (4 and 3 mg/dL, p = 0.003 and 0.02), respectively. HC and CHL subjects did not differ by apo E phenotype distribution. Postprandial triglyceride-rich lipoproteins and LDL subclass phenotype were unaffected by egg feeding in subsets of subjects.

CONCLUSIONS

CHL subjects ingesting a Step I Diet in a free-living setting are sensitive to egg feeding and should benefit from dietary cholesterol restriction. The limited LDL-C rise in HC subjects resembles that seen in egg-fed normocholesterolemic subjects ingesting a Step I Diet, but requires confirmation.

Authors+Show Affiliations

Knopp RH
Northwest Lipid Research Clinic, University of Washington, Seattle 98104, USA.
Retzlaff BM
No affiliation info available
Walden CE
No affiliation info available
Dowdy AA
No affiliation info available
Tsunehara CH
No affiliation info available
Austin MA
No affiliation info available
Nguyen T
No affiliation info available

MeSH

AdultAgedApolipoprotein A-IApolipoproteins BApolipoproteins EBlood GlucoseBody Mass IndexBody WeightCholesterolCholesterol, DietaryCholesterol, HDLCholesterol, LDLCholesterol, VLDLDiet, Fat-RestrictedDietary FatsDietary FiberDietary ProteinsDouble-Blind MethodEggsFastingFemaleHumansHypercholesterolemiaHyperlipidemiasInsulinLipidsMaleMiddle AgedPatient CompliancePhenotypeTriglycerides

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9430083

Citation

Knopp, R H., et al. "A Double-blind, Randomized, Controlled Trial of the Effects of Two Eggs Per Day in Moderately Hypercholesterolemic and Combined Hyperlipidemic Subjects Taught the NCEP Step I Diet." Journal of the American College of Nutrition, vol. 16, no. 6, 1997, pp. 551-61.
Knopp RH, Retzlaff BM, Walden CE, et al. A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet. J Am Coll Nutr. 1997;16(6):551-61.
Knopp, R. H., Retzlaff, B. M., Walden, C. E., Dowdy, A. A., Tsunehara, C. H., Austin, M. A., & Nguyen, T. (1997). A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet. Journal of the American College of Nutrition, 16(6), 551-61.
Knopp RH, et al. A Double-blind, Randomized, Controlled Trial of the Effects of Two Eggs Per Day in Moderately Hypercholesterolemic and Combined Hyperlipidemic Subjects Taught the NCEP Step I Diet. J Am Coll Nutr. 1997;16(6):551-61. PubMed PMID: 9430083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet. AU - Knopp,R H, AU - Retzlaff,B M, AU - Walden,C E, AU - Dowdy,A A, AU - Tsunehara,C H, AU - Austin,M A, AU - Nguyen,T, PY - 1998/1/16/pubmed PY - 1998/1/16/medline PY - 1998/1/16/entrez SP - 551 EP - 61 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 16 IS - 6 N2 - OBJECTIVE: We investigated the effect of egg feeding in 161 hypercholesterolemic (HC) or combined hyperlipidemic (CHL) free-living subjects taught the NCEP Step I Diet. METHODS: Subjects had LDL-C between 3.36 and 4.91 mmol/L (130 and 190 mg/dL). HC subjects had triglyceride concentrations < 75th %-ile, CHL > or = 75th %-ile. Six weeks after instituting the Step I Diet, subjects were randomized to two eggs or egg substitute daily for 12 weeks. RESULTS: Mean dietary intake (9-day food records) was within NCEP guidelines and 131 subjects finished with stable weight and adherence > 80%. Placebo group lipoprotein lipids were unchanged at study end for both HC (n = 35) and CHL (n = 21) subjects. Egg-fed HC subjects (n = 44) increased LDL-C nonsignificantly, 0.07 mmol/L (3 mg/dL) (p = 0.49). Egg-fed CHL subjects (n = 31) increased LDL-C 0.31 mmol/L (12 mg/dL) (p < 0.001). HDL-C increased significantly in both HC and CHL groups, 0.10 and 0.08 mmol/L (4 and 3 mg/dL, p = 0.003 and 0.02), respectively. HC and CHL subjects did not differ by apo E phenotype distribution. Postprandial triglyceride-rich lipoproteins and LDL subclass phenotype were unaffected by egg feeding in subsets of subjects. CONCLUSIONS: CHL subjects ingesting a Step I Diet in a free-living setting are sensitive to egg feeding and should benefit from dietary cholesterol restriction. The limited LDL-C rise in HC subjects resembles that seen in egg-fed normocholesterolemic subjects ingesting a Step I Diet, but requires confirmation. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/9430083/A_double_blind_randomized_controlled_trial_of_the_effects_of_two_eggs_per_day_in_moderately_hypercholesterolemic_and_combined_hyperlipidemic_subjects_taught_the_NCEP_step_I_diet_ DB - PRIME DP - Unbound Medicine ER -