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Localized amyloidosis of the seminal vesicle. Possible association with hormonally treated prostatic adenocarcinoma.
Arch Pathol Lab Med. 1997 Dec; 121(12):1265-8.AP

Abstract

OBJECTIVE

Localized seminal vesicle amyloidosis is an unusual finding in surgical pathology material. Previous studies have demonstrated that the amyloid is directly produced by the seminal vesicle epithelial cells. We investigated the possible association of seminal vesicle amyloid in patients hormonally treated for prostate carcinoma.

METHODS

Cases were collected from over 200 prostate needle biopsies, seminal vesicle biopsies, and prostatectomy specimens from the surgical pathology files at The Mount Sinai Hospital, New York, NY. None of the patients with seminal vesicle amyloidosis had a chronic inflammatory disorder, serum or urine protein abnormalities, or other identifiable masses.

RESULTS

Six cases of localized seminal vesicle amyloidosis were found in the surgical pathology material examined. Five of the six cases had prostatic carcinoma, and one case was seen in a biopsy for benign prostatic hyperplasia. Four of the five carcinoma cases had prior hormonal treatment (luteinizing hormone-releasing hormone agonist with an antiandrogen agent, and one patient, in addition, had received radiotherapy). The amyloid deposits were limited to the seminal vesicle lamina propria without involvement of vascular walls. The amyloid reacted with Congo red staining that was sensitive to potassium permanganate. Immunohistochemically, all cases were negative for AA amyloid, beta 2-microglobulin, and kappa and lambda light chains.

CONCLUSION

We raise the possibility that in some instances, prior hormonal therapy may act as a seminal vesicle epithelial stimulant for the elaboration of this protein.

Authors+Show Affiliations

Unger PD
Department of Pathology, Mount Sinai Hospital, New York, NY 10029, USA.
Wang Q
No affiliation info available
Gordon RE
No affiliation info available
Stock R
No affiliation info available
Stone N
No affiliation info available

MeSH

AdenocarcinomaAgedAmyloidosisAndrogen AntagonistsAntineoplastic Agents, HormonalBiopsyDrug Therapy, CombinationEpithelial CellsFlutamideGonadotropin-Releasing HormoneHumansImmunoglobulin gamma-ChainsImmunoglobulin kappa-ChainsImmunohistochemistryLeuprolideMaleMiddle AgedProstatic NeoplasmsProteinuriaSeminal VesiclesSerum Amyloid A ProteinTesticular Diseasesbeta 2-Microglobulin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9431316

Citation

Unger, P D., et al. "Localized Amyloidosis of the Seminal Vesicle. Possible Association With Hormonally Treated Prostatic Adenocarcinoma." Archives of Pathology & Laboratory Medicine, vol. 121, no. 12, 1997, pp. 1265-8.
Unger PD, Wang Q, Gordon RE, et al. Localized amyloidosis of the seminal vesicle. Possible association with hormonally treated prostatic adenocarcinoma. Arch Pathol Lab Med. 1997;121(12):1265-8.
Unger, P. D., Wang, Q., Gordon, R. E., Stock, R., & Stone, N. (1997). Localized amyloidosis of the seminal vesicle. Possible association with hormonally treated prostatic adenocarcinoma. Archives of Pathology & Laboratory Medicine, 121(12), 1265-8.
Unger PD, et al. Localized Amyloidosis of the Seminal Vesicle. Possible Association With Hormonally Treated Prostatic Adenocarcinoma. Arch Pathol Lab Med. 1997;121(12):1265-8. PubMed PMID: 9431316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Localized amyloidosis of the seminal vesicle. Possible association with hormonally treated prostatic adenocarcinoma. AU - Unger,P D, AU - Wang,Q, AU - Gordon,R E, AU - Stock,R, AU - Stone,N, PY - 1998/2/7/pubmed PY - 1998/2/7/medline PY - 1998/2/7/entrez SP - 1265 EP - 8 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 121 IS - 12 N2 - OBJECTIVE: Localized seminal vesicle amyloidosis is an unusual finding in surgical pathology material. Previous studies have demonstrated that the amyloid is directly produced by the seminal vesicle epithelial cells. We investigated the possible association of seminal vesicle amyloid in patients hormonally treated for prostate carcinoma. METHODS: Cases were collected from over 200 prostate needle biopsies, seminal vesicle biopsies, and prostatectomy specimens from the surgical pathology files at The Mount Sinai Hospital, New York, NY. None of the patients with seminal vesicle amyloidosis had a chronic inflammatory disorder, serum or urine protein abnormalities, or other identifiable masses. RESULTS: Six cases of localized seminal vesicle amyloidosis were found in the surgical pathology material examined. Five of the six cases had prostatic carcinoma, and one case was seen in a biopsy for benign prostatic hyperplasia. Four of the five carcinoma cases had prior hormonal treatment (luteinizing hormone-releasing hormone agonist with an antiandrogen agent, and one patient, in addition, had received radiotherapy). The amyloid deposits were limited to the seminal vesicle lamina propria without involvement of vascular walls. The amyloid reacted with Congo red staining that was sensitive to potassium permanganate. Immunohistochemically, all cases were negative for AA amyloid, beta 2-microglobulin, and kappa and lambda light chains. CONCLUSION: We raise the possibility that in some instances, prior hormonal therapy may act as a seminal vesicle epithelial stimulant for the elaboration of this protein. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/9431316/Localized_amyloidosis_of_the_seminal_vesicle__Possible_association_with_hormonally_treated_prostatic_adenocarcinoma_ L2 - http://www.diseaseinfosearch.org/result/380 DB - PRIME DP - Unbound Medicine ER -