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[Effects of various prokinetic drugs on gastrointestinal transit times in patients with progressive systemic scleroderma].
Z Gastroenterol. 1997 Oct; 35(10):905-12.ZG

Abstract

The intestine is involved in about half of the cases with progressive-systemic sclerosis. Intestinal transit disturbances which are caused by neuropathy of the enteric nerve system occur frequently. However, upto-date only few studies which determined the effect of prokinetic drugs exist. Patients with intestinal involvement caused by progressive-systemic sclerosis were treated with the prokinetic drugs cisapride (20 mg, TID; n = 9), erythromycin (250 mg, TID; n = 7) and octreotide (50 micrograms s. c., at night time; n = 5) over a period of four weeks. At study entry and after each treatment period the transit times through the stomach, small and large intestine were evaluated by use of the metal-detector test. Gastric emptying was only accelerated by erythromycin (42 +/- 3 min vs. 54 +/- 6 min; p = 0.0422), whereas treatment with cisapride and octreotide did not result in significant changes (48 +/- 4 min; p = 0.3743 and 44 +/- 4 min; p = 0.1975; resp.). Small intestinal transit times were not altered significantly by cisapride (108 +/- 15 min vs. 108 +/- 9 min; p = 0.2733), crythromycin (92 +/- 8 min; p = 0.0707) or octreotide (106 +/- 12 min; p = 0.8927). Furthermore colonic transit was not fastened by none of the prokinetic agents (study entry: 68 +/- 12 h; cisapride: 88 +/- 12 h; p = 0.0569; erythromycin 77 +/- 14 h; p = 0.7349; octreotide 107 +/- 14 h; p = 0.8927). Four patients were withdrawn from the study because of diarrhea. Prokinetic drugs do not seem to have a major impact on intestinal transit times in patients with progressive-systemic sclerosis. The use of these drugs is limited because of frequent side effects.

Authors+Show Affiliations

Medizinische Klinik, Klinikum Innenstadt, Ludwig-Maximilians-Universität, München.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ger

PubMed ID

9432812

Citation

Folwaczny, C, et al. "[Effects of Various Prokinetic Drugs On Gastrointestinal Transit Times in Patients With Progressive Systemic Scleroderma]." Zeitschrift Fur Gastroenterologie, vol. 35, no. 10, 1997, pp. 905-12.
Folwaczny C, Läritz M, Meurer M, et al. [Effects of various prokinetic drugs on gastrointestinal transit times in patients with progressive systemic scleroderma]. Z Gastroenterol. 1997;35(10):905-12.
Folwaczny, C., Läritz, M., Meurer, M., Endres, S. P., König, A., & Schindlbeck, N. (1997). [Effects of various prokinetic drugs on gastrointestinal transit times in patients with progressive systemic scleroderma]. Zeitschrift Fur Gastroenterologie, 35(10), 905-12.
Folwaczny C, et al. [Effects of Various Prokinetic Drugs On Gastrointestinal Transit Times in Patients With Progressive Systemic Scleroderma]. Z Gastroenterol. 1997;35(10):905-12. PubMed PMID: 9432812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of various prokinetic drugs on gastrointestinal transit times in patients with progressive systemic scleroderma]. AU - Folwaczny,C, AU - Läritz,M, AU - Meurer,M, AU - Endres,S P, AU - König,A, AU - Schindlbeck,N, PY - 1998/2/12/pubmed PY - 1998/2/12/medline PY - 1998/2/12/entrez SP - 905 EP - 12 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 35 IS - 10 N2 - The intestine is involved in about half of the cases with progressive-systemic sclerosis. Intestinal transit disturbances which are caused by neuropathy of the enteric nerve system occur frequently. However, upto-date only few studies which determined the effect of prokinetic drugs exist. Patients with intestinal involvement caused by progressive-systemic sclerosis were treated with the prokinetic drugs cisapride (20 mg, TID; n = 9), erythromycin (250 mg, TID; n = 7) and octreotide (50 micrograms s. c., at night time; n = 5) over a period of four weeks. At study entry and after each treatment period the transit times through the stomach, small and large intestine were evaluated by use of the metal-detector test. Gastric emptying was only accelerated by erythromycin (42 +/- 3 min vs. 54 +/- 6 min; p = 0.0422), whereas treatment with cisapride and octreotide did not result in significant changes (48 +/- 4 min; p = 0.3743 and 44 +/- 4 min; p = 0.1975; resp.). Small intestinal transit times were not altered significantly by cisapride (108 +/- 15 min vs. 108 +/- 9 min; p = 0.2733), crythromycin (92 +/- 8 min; p = 0.0707) or octreotide (106 +/- 12 min; p = 0.8927). Furthermore colonic transit was not fastened by none of the prokinetic agents (study entry: 68 +/- 12 h; cisapride: 88 +/- 12 h; p = 0.0569; erythromycin 77 +/- 14 h; p = 0.7349; octreotide 107 +/- 14 h; p = 0.8927). Four patients were withdrawn from the study because of diarrhea. Prokinetic drugs do not seem to have a major impact on intestinal transit times in patients with progressive-systemic sclerosis. The use of these drugs is limited because of frequent side effects. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/9432812/[Effects_of_various_prokinetic_drugs_on_gastrointestinal_transit_times_in_patients_with_progressive_systemic_scleroderma]_ L2 - http://www.diseaseinfosearch.org/result/6459 DB - PRIME DP - Unbound Medicine ER -