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Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme.
Planta Med. 1997 Dec; 63(6):508-10.PM

Abstract

The antibacterial activity of extracts and isolated constituents (scopoletin, umckalin, 5,6,7-trimethoxycoumarin, 6,8-dihydroxy-5,7-dimethoxycoumarin, (+)-catechin, gallic acid and its methyl ester) of Pelargonium sidoides and Pelargonium reniforme (Geraniaceae), plant species used in folk medicine by the Southern African native population, was evaluated against 8 microorganisms, including 3 Gram-positive (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic Streptococcus 1451) and 5 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae). Minimum inhibitory concentrations (MICs) varied with the preparation of the extracts and microorganisms tested, from about 0.6 mg/ml for aqueous phases to over 10 mg/ml for crude Pelargonium extracts. With the exception of the ineffective (+)-catechin, all the potentially active compounds exhibited antibacterial activities with MICs of 200-1000 micrograms/ml. The results provide for a rational basis of the traditional use of the titled Pelargonium species.

Authors+Show Affiliations

Institut für Pharmazie II, Pharmazeutische Biologie, Freie Universität Berlin, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9434601

Citation

Kayser, O, and H Kolodziej. "Antibacterial Activity of Extracts and Constituents of Pelargonium Sidoides and Pelargonium Reniforme." Planta Medica, vol. 63, no. 6, 1997, pp. 508-10.
Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63(6):508-10.
Kayser, O., & Kolodziej, H. (1997). Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Medica, 63(6), 508-10.
Kayser O, Kolodziej H. Antibacterial Activity of Extracts and Constituents of Pelargonium Sidoides and Pelargonium Reniforme. Planta Med. 1997;63(6):508-10. PubMed PMID: 9434601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. AU - Kayser,O, AU - Kolodziej,H, PY - 1998/1/22/pubmed PY - 1998/1/22/medline PY - 1998/1/22/entrez SP - 508 EP - 10 JF - Planta medica JO - Planta Med VL - 63 IS - 6 N2 - The antibacterial activity of extracts and isolated constituents (scopoletin, umckalin, 5,6,7-trimethoxycoumarin, 6,8-dihydroxy-5,7-dimethoxycoumarin, (+)-catechin, gallic acid and its methyl ester) of Pelargonium sidoides and Pelargonium reniforme (Geraniaceae), plant species used in folk medicine by the Southern African native population, was evaluated against 8 microorganisms, including 3 Gram-positive (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic Streptococcus 1451) and 5 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae). Minimum inhibitory concentrations (MICs) varied with the preparation of the extracts and microorganisms tested, from about 0.6 mg/ml for aqueous phases to over 10 mg/ml for crude Pelargonium extracts. With the exception of the ineffective (+)-catechin, all the potentially active compounds exhibited antibacterial activities with MICs of 200-1000 micrograms/ml. The results provide for a rational basis of the traditional use of the titled Pelargonium species. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/9434601/Antibacterial_activity_of_extracts_and_constituents_of_Pelargonium_sidoides_and_Pelargonium_reniforme_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957752 DB - PRIME DP - Unbound Medicine ER -