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A prospective study of association of monounsaturated fat and other types of fat with risk of breast cancer.
Arch Intern Med 1998; 158(1):41-5AI

Abstract

BACKGROUND

Animal studies suggest that monounsaturated and polyunsaturated fat may have opposite effects on the risk of breast cancer.

METHODS

We performed a population-based prospective cohort study, including 61,471 women aged 40 to 76 years from 2 counties in central Sweden who did not have any previous diagnosis of cancer; 674 cases of invasive breast cancer occurred during an average follow-up of 4.2 years. All subjects answered a validated 67-item food frequency questionnaire at baseline. Cox proportional hazards models were used to obtain adjusted rate ratio (RR) estimates with 95% confidence intervals (CIs).

RESULTS

After mutual adjustment of different types of fat, an inverse association with monounsaturated fat and a positive association with polyunsaturated fat were found. The RR for each 10-g increment in daily intake of monounsaturated fat was 0.45 (95% CI, 0.22-0.95), whereas the RR for a 5-g increment of polyunsaturated fat was 1.69 (95% CI, 1.02-2.78); the increments correspond to approximately 2 SDs of intake in the population. Comparing the highest quartile of intake with the lowest, we found an RR of 0.8 (95% CI, 0.5-1.2) for monounsaturated fat and 1.2 (95% CI, 0.9-1.6) for polyunsaturated fat. Saturated fat was not associated with the risk of breast cancer.

CONCLUSIONS

Our results indicate that various types of fat may have specific opposite effects on the risk of breast cancer that closely resemble the corresponding effects in experimental animals. Research investigations and health policy considerations should take into account the emerging evidence that monounsaturated fat might be protective for risk of breast cancer.

Authors+Show Affiliations

Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9437377

Citation

Wolk, A, et al. "A Prospective Study of Association of Monounsaturated Fat and Other Types of Fat With Risk of Breast Cancer." Archives of Internal Medicine, vol. 158, no. 1, 1998, pp. 41-5.
Wolk A, Bergström R, Hunter D, et al. A prospective study of association of monounsaturated fat and other types of fat with risk of breast cancer. Arch Intern Med. 1998;158(1):41-5.
Wolk, A., Bergström, R., Hunter, D., Willett, W., Ljung, H., Holmberg, L., ... Adami, H. O. (1998). A prospective study of association of monounsaturated fat and other types of fat with risk of breast cancer. Archives of Internal Medicine, 158(1), pp. 41-5.
Wolk A, et al. A Prospective Study of Association of Monounsaturated Fat and Other Types of Fat With Risk of Breast Cancer. Arch Intern Med. 1998 Jan 12;158(1):41-5. PubMed PMID: 9437377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of association of monounsaturated fat and other types of fat with risk of breast cancer. AU - Wolk,A, AU - Bergström,R, AU - Hunter,D, AU - Willett,W, AU - Ljung,H, AU - Holmberg,L, AU - Bergkvist,L, AU - Bruce,A, AU - Adami,H O, PY - 1998/1/23/pubmed PY - 1998/1/23/medline PY - 1998/1/23/entrez SP - 41 EP - 5 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 158 IS - 1 N2 - BACKGROUND: Animal studies suggest that monounsaturated and polyunsaturated fat may have opposite effects on the risk of breast cancer. METHODS: We performed a population-based prospective cohort study, including 61,471 women aged 40 to 76 years from 2 counties in central Sweden who did not have any previous diagnosis of cancer; 674 cases of invasive breast cancer occurred during an average follow-up of 4.2 years. All subjects answered a validated 67-item food frequency questionnaire at baseline. Cox proportional hazards models were used to obtain adjusted rate ratio (RR) estimates with 95% confidence intervals (CIs). RESULTS: After mutual adjustment of different types of fat, an inverse association with monounsaturated fat and a positive association with polyunsaturated fat were found. The RR for each 10-g increment in daily intake of monounsaturated fat was 0.45 (95% CI, 0.22-0.95), whereas the RR for a 5-g increment of polyunsaturated fat was 1.69 (95% CI, 1.02-2.78); the increments correspond to approximately 2 SDs of intake in the population. Comparing the highest quartile of intake with the lowest, we found an RR of 0.8 (95% CI, 0.5-1.2) for monounsaturated fat and 1.2 (95% CI, 0.9-1.6) for polyunsaturated fat. Saturated fat was not associated with the risk of breast cancer. CONCLUSIONS: Our results indicate that various types of fat may have specific opposite effects on the risk of breast cancer that closely resemble the corresponding effects in experimental animals. Research investigations and health policy considerations should take into account the emerging evidence that monounsaturated fat might be protective for risk of breast cancer. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/9437377/A_prospective_study_of_association_of_monounsaturated_fat_and_other_types_of_fat_with_risk_of_breast_cancer_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/158/pg/41 DB - PRIME DP - Unbound Medicine ER -